[1]陈译文,王昭杰,夏杰,等.静息态功能磁共振对典型及变异型伴中央颞区棘波儿童良性癫痫的脑功能网络研究[J].医学研究与战创伤救治(原医学研究生学报),2026,39(01):32-36.[doi:10.16571/j.cnki.2097-2768.2026.01.005]
　CHEN Yiwen,WANG Zhaojie,XIA Jie,et al.A study on restingstate functional magnetic resonance imaging (fMRI) of the brain functional network of typical in typical and variant types of childhood epilepsy with centrotemporal spikes[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2026,39(01):32-36.[doi:10.16571/j.cnki.2097-2768.2026.01.005]
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静息态功能磁共振对典型及变异型伴中央颞区棘波儿童良性癫痫的脑功能网络研究()

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第39卷
期数:
2026年01期
页码:
32-36
栏目:
临床研究
出版日期:
2026-01-20

文章信息/Info

Title:
A study on restingstate functional magnetic resonance imaging (fMRI) of the brain functional network of typical in typical and variant types of childhood epilepsy with centrotemporal spikes
作者:
陈译文1; 王昭杰1; 夏杰2; 姚馨荷1; 李玉卓1; 张志强1
1.南京医科大学金陵临床医学院（东部战区总医院）放射诊断科，江苏南京 2100022.电子科技大学生命科学与技术学院，四川成都 611731
Author(s):
CHEN Yiwen1;  WANG Zhaojie1;  XIA Jie2;  YAO Xinhe1;  LI Yuzhuo1;  ZHANG Zhiqiang1
(1.Department of Radiology, Jinling Hospital, Nanjing Medical University/General Hospital of Eastern Theater Command, PLA, Nanjing 210002, Jiangsu, China; 2.School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan, China)
关键词:
伴中央颞区棘波的儿童良性癫痫; rolandic癫痫; 静息态功能磁共振成像; 图论; 脑功能网络
Keywords:
benign childhood epilepsy with centrotemporal spikes;  rolandic epilepsy;  restingstate functional magnetic resonance imaging;  graph theory analysis;  functional brain network
分类号:
R749.1
DOI:
10.16571/j.cnki.2097-2768.2026.01.005
文献标志码:
A
摘要:
目的通过静息态功能磁共振成像结合图论分析方法，探究典型及变异型伴中央颞区棘波儿童良性癫痫（BECTS）的脑功能网络拓扑结构的差异。方法回顾性分析2012年12月至2022年1月就诊于东部战区总医院的BECTS患儿的临床资料。依据症状及脑电图特征分为典型BECTS组（51例）和变异型BECTS组（30例）。采用基于静息态功能磁共振成像，并结合图论分析方法，构建患儿的脑功能连接网络，分析其全局及节点指标拓扑指标，从而探究不同类型BECTS脑网络特征的差异性。结果两组BECTS患者的脑功能网络均表现出小世界特性，但变异型BECTS脑网络受到更大程度的损害。与典型BECTS组比较，变异型BECTS组的聚类系数和局部效率显著降低（P＜0.05），变异型BECTS组右侧小脑的节点局部效率也显著降低（P=0.006）。结论典型与变异型BECTS仍保留了小世界属性，但变异型BECTS部分全局及节点指标存在异常。
Abstract:
ObjectiveThe research aims to study the differences in brain functional network topology between typical and variant benign childhood epilepsy (BECTS) with centrotemporal spikes using restingstate functional magnetic resonance imaging combined with graph theory analysis.MethodsA retrospective analysis was conducted on the clinical data of children with braininduced cerebrovascular accidental spondylitis (BECTS) who visited the Eastern Theater Command General Hospital between December 2012 and January 2022. They were divided into typical group (cases=51) and atypical group (cases=30), based on symptoms and electroencephalogram characteristics. Restingstate functional magnetic resonance imaging (fMRI) combined with graph theory analysis was used to construct the brain functional connectivity networks of the children, and their global and node topological indices were analyzed to explore the differences in brain network characteristics between different types of BECTS.ResultsBoth groups of BECTS patients exhibited smallworld characteristics in their brain functional networks, but the brain networks of variant BECTS showed greater damage. Compared with the typical BECTS group, the clustering coefficient and local efficiency of the atypical BECTS group were significantly decreased (P< 0.05). The node local efficiency of the right cerebellum in the atypical BECTS group was also significantly decreased (P=0.006, FDR corrected).ConclusionBoth typical and variant BECTS retain smallworld property, but some global and node indicators of variant BECTS are abnormal.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（82371951）
更新日期/Last Update: 2026-01-20