[1]容子婷,刘程曦,肖媛,等.谷氨酸能神经元在全身麻醉及睡眠觉醒中的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2026,39(01):89-94.[doi:10.16571/j.cnki.2097-2768.2026.01.015]
 RONG Ziting,LIU Chengxi,XIAO Yuan,et al.Research progress of glutamatergic neurons in general anesthesia and sleepwake[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2026,39(01):89-94.[doi:10.16571/j.cnki.2097-2768.2026.01.015]
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谷氨酸能神经元在全身麻醉及睡眠觉醒中的研究进展()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第39卷
期数:
2026年01期
页码:
89-94
栏目:
综述
出版日期:
2026-01-20

文章信息/Info

Title:
Research progress of glutamatergic neurons in general anesthesia and sleepwake
作者:
容子婷刘程曦肖媛刘文捷王德明
南华大学附属第二医院麻醉与疼痛研究所/湖南省急慢性疼痛临床医学研究中心,湖南衡阳 421000
Author(s):
RONG Ziting LIU Chengxi XIAO Yuan LIU Wenjie WANG Deming
(Department of Anesthesiology, the Second Affiliated Hospital, University of South China/Clinical Research Center for Acute and Chronic Pain in Hunan Province, Hengyang 421000, Hunan, China)
关键词:
谷氨酸能神经元谷氨酸全身麻醉睡眠觉醒
Keywords:
glutamatergic neurons glutamate general anesthesia sleepwake
分类号:
R614
DOI:
10.16571/j.cnki.2097-2768.2026.01.015
文献标志码:
A
摘要:
全身麻醉与自然生理睡眠存在相似之处,调控经典睡眠觉醒通路现被证明参与全身麻醉,此前关于全身麻醉与睡眠觉醒的研究主要集中在神经通路,其中神经元网络的作用显得尤为重要。谷氨酸能神经元在大脑广泛存在且与神经通路普遍联系,文章主要从谷氨酸能神经元出发系统探讨其在麻醉与睡眠觉醒意识调控的关键作用,为阐明全麻药物作用机制及意识神经基础提供新视角。
Abstract:
General anesthesia shares similarities with natural physiological sleep. The regulation of the classical sleepwake circuitry has been proven to be involved in general anesthesia. Previously, studies on general anesthesia and sleepwake have mainly focused on neural circuits, among which the role of neuronal networks is particularly significant. Glutamatergic neurons are widely distributed throughout the brain and exhibit extensive connectivity within neural circuits. This review systematically examines the critical roles of glutamatergic neurons in regulating anesthesia, sleepwake cycles, and conscious states. The findings provide novel insights into the mechanisms underlying general anesthetic actions and the neural substrates of consciousness.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(82301447);湖南省自然科学基金(2025JJ50617);湖南省卫生健康委2024年度卫生依托单位自筹项目(W20243179)
更新日期/Last Update: 2026-01-20