[1]杨英,孙迎,苏鹏,等.HIF1α介导肿瘤相关巨噬细胞代谢重编程促肿瘤进展的研究现状[J].医学研究与战创伤救治(原医学研究生学报),2026,39(01):95-100.[doi:10.16571/j.cnki.2097-2768.2026.01.016]
 YANG Ying,SUN Ying,SU Peng,et al.Research progress of HIF1αmediated metabolic reprogramming in tumorassociated macrophages promoting tumor progression[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2026,39(01):95-100.[doi:10.16571/j.cnki.2097-2768.2026.01.016]
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HIF1α介导肿瘤相关巨噬细胞代谢重编程促肿瘤进展的研究现状()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第39卷
期数:
2026年01期
页码:
95-100
栏目:
综述
出版日期:
2026-01-20

文章信息/Info

Title:
Research progress of HIF1αmediated metabolic reprogramming in tumorassociated macrophages promoting tumor progression
作者:
杨英1孙迎1苏鹏2李春鸣2
1.遵义医科大学第二附属医院皮肤科,贵州遵义 5630002.遵义医科大学附属医院病理科,贵州遵义 563003
Author(s):
YANG Ying1 SUN Ying1 SU Peng2 LI Chunming2
(1.Department of Dermatology, the Second Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China; 2. Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou, China)
关键词:
HIF1α肿瘤相关巨噬细胞代谢重编程肿瘤微环境肿瘤进展
Keywords:
HIF1α tumor associated macrophages metabolic reprogramming tumor microenvironment tumor progression
分类号:
R730
DOI:
10.16571/j.cnki.2097-2768.2026.01.016
文献标志码:
A
摘要:
缺氧诱导因子1α(HIF1α)作为缺氧环境中的核心转录因子,在肿瘤微环境(TME)中发挥关键调控作用,它不仅可直接调控细胞关键基因的转录功能并参与多种信号的转导,还能调控细胞代谢特征。肿瘤相关巨噬细胞(TAMs)是重要的一类免疫细胞,在独特的缺氧、酸性等肿瘤微环境中,TAMs功能可由最初的促炎转为促肿瘤作用。目前研究发现HIF1α激活可诱导TAMs发生代谢重编程,推动TAMs向M2型极化,进而使其发挥促肿瘤作用。文章主要从HIF1α对TAMs中葡萄糖、脂肪、氨基酸的代谢调控机制及HIF1αTAMs代谢轴促进肿瘤进展机制等方面进行综述。[关键词]HIF1α;肿瘤相关巨噬细胞;代谢重编程;肿瘤微环境;肿瘤进展
Abstract:
Hypoxiainducible factor 1α (HIF1α), as a core transcription factor in hypoxic environments, exerts a critical regulatory role in the tumor microenvironment (TME). It not only directly regulates the transcriptional function of key cellular genes and participates in multiple signaling transduction pathways, but also modulates cellular metabolic characteristics. Tumorassociated macrophages (TAMs) represent a key subset of immune cells. Within the unique hypoxic, acidic tumor microenvironment, TAMs can switch their functional phenotype from initially proinflammatory to protumorigenic. Accumulating evidence indicates that HIF1α activation induces metabolic reprogramming in TAMs, promoting their polarization toward the M2 phenotype and thereby enhancing their protumorigenic effects. This review primarily summarizes the regulatory mechanisms of HIF1α on glucose, lipid, and amino acid metabolism in TAMs, as well as the mechanisms by which the HIF1αTAMs metabolic axis facilitates tumor progression.

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备注/Memo

备注/Memo:
基金项目:贵州省卫生健康委(gzwkj2025063);贵州省普通高等学校青年科技人才成长项目(黔教合KY字[2022]286号);遵义市科技计划项目[遵市科合HZ字(2024)189号 (2025)128号]
更新日期/Last Update: 2026-01-20