|本期目录/Table of Contents|

[1]马春曦,彭国林,张晓云.新三联方案根除幽门螺杆菌的疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2008,10(03):192.
　MA Chun-xi,PENG Guo-lin,ZHANG Xiao-yun.Effect of levofloxacin, amoxicillin and omeprazole triad system as rescue therapy for Helicobacter pylori infection[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2008,10(03):192.
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新三联方案根除幽门螺杆菌的疗效观察()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第10卷
期数:
2008年03期
页码:
192
栏目:
出版日期:
2008-05-20

文章信息/Info

Title:
Effect of levofloxacin, amoxicillin and omeprazole triad system as rescue therapy for Helicobacter pylori infection
文章编号:
1672-271X(2008)03-0192-03
作者:
马春曦1;  彭国林1;  张晓云2
1解放军第184医院，1.消化内科；2.实验诊断科，江西鹰潭 335000
Author(s):
MA Chun-xi1;  PENG Guo-lin1;  ZHANG Xiao-yun2
1. Department of Gastroenterology，2. Department of Laboratory Diagnosis，the 184th Hospital of PLA，Yingtan 335000,Jiangxi，China
关键词:
新三联方案; 左氧氟沙星; 幽门螺杆菌; 补救治疗
Keywords:
New triad system; Levofloxacin; Helicobacter pylori; Rescue therapy
分类号:
R573
DOI:
-
文献标志码:
A
摘要:
目的 观察含左氧氟沙星新三联方案对标准三联疗法根除幽门螺杆菌(Helicobacter pylori，Hp)失败患者进行补救治疗的根除效果。方法 将标准三联疗法根除Hp失败的50例患者随机分为2组:治疗组给予奥美拉唑20 mg+左氧氟沙星200 mg+阿莫西林1 000 mg，口服7 d，均2次/d；对照组给予胶体次枸橼酸铋钾200 mg+奥美拉唑20 mg+克拉霉素500 mg+阿莫西林1 000 mg，口服7 d，均2次/d；治疗后4周行快速尿素酶试验和14C-尿素呼气试验，观察其根除率。结果 50例患者中有45例完成治疗，治疗组按意图治疗(ITT)分析幽门螺杆菌根除率为76.00%(19/25)，按试验方案(PP)为82.61％(19/23)，对照组根除率按ITT为60.00%(15/25)，按PP为68.18%(15/22)，均显著低于治疗组(P＜0.05)。结论 对Hp根除治疗失败的患者，新三联方案较四联疗法能获得较高的根除率，且副反应较小。
Abstract:
Objective To evaluate the effect of rescue therapy for eradicating Helicobacter pylori(Hp) with levofloxacin amoxicillin and omeprazole triad system. Methods Fifty patients with Helicobacter pylori infection were randomized divided treatment group and control group, 25 patients of treatment group treated with omeprazole 20 mg, levofloxacin 20 mg，amoxicillin 1 000 mg，and 25 patients of control group treated with collodial bismuth subcitrate 200 mg，omeprazole 20 mg，amoxicillin 1 000 mg，clarithromycin 500 mg bid for 7 days. The 14C-urea breath test(UBT)was performed to evaluate the success of Hp eradication，at least four weeks after completion of therapy. Results By intention-to-treat(ITT) analysis and per-protocol(PP) analysis，the rates of eradication of H.pylori of treatment group were 76.00%(19/25) and 82.61%(19/23) respectively. The rates of eradication of control group were 60.00%(15/25) and 68.18%(15/22) respectively，which were lower significantly than that of treatment groups(P<0.05).Conclusion Levofloxacin，amoxicillin and omeprazole triad system as rescue therapy has a satisfactory eradicating rate for previous treatment failure of H.pylori infection.

参考文献/References:

[1]O’Morain C, Montague S. Challenges to therapy in the future[J]. Helicobacter, 2000, 5(11):23-31.
[2]中华医学会消化病分会.幽门螺杆菌共识意见(2003·安徽桐城)[Ｊ].中华消化杂志，2004，24(2):126-127.
[3]Kim JJ, Reddy R, Lee M, et al. Analysis of metronidazole, clarithromycin and tetracycline resistance of Helicobacter pylori isolates from Korea[Ｊ]. J Antimicrob Chemother，2001，47(4):459-461.
[4]刘文忠，施 尧，戈之铮. 幽门螺杆菌研究进展[M]．上海:上海科学技术文献出版社,2001:10，220．
[5]Tankovic J，Lamarque D，Lascols C，et al.Impact of helicobac- ter pylori resistance to clarithromycin on the efficacy of the omeprazole-amoxi cillin-clarithromycin therapy[J].Aliment Pharmacol Ther，2001，15:707-713.
[6]邹 军，李欣欣，杨昭徐. 左氧氟沙星对幽门螺杆菌体外抗菌活性的评价[Ｊ]．中国抗生素杂志，2003，5(28):292.
[7]Cammarota G, Cianci R, Cannizzaro O, et al．Efficacy of two one-week rabeprazole／levofloxacin-based triple therapies for Helicobacter pylori infection[Ｊ]．Aliment Pharmacol Ther, 2000，14(10):1339-1343.
[8]Di Caw S, Assunta Zoceo M, Cremonini F, et al. Levofloxac- in based regimen for the eradication of Helicobacter pylori[Ｊ]. Eur J Gastroenterol Hepato1,2002，14(12):1309-1312.
[9]Pemi F, Festa V, Meda A, et al. Randomized study of diffe- rent‘second-line’therapies for Helicobacter pylori infection after failure of the standard ‘Maastricht triple therapy’[Ｊ]. Aliment Pharmaco Ther，2003，18(8):815-820.
[10]Watanabe Y， Aoymna N， Shirasaka D， et al. Levofloxacin based triple therapy as a second-line treatment after failure of helicobacter pylori eradication with standard triple therapy[Ｊ]. Dig Liver Dis, 2003,35 (10):711-715.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-11-22