|本期目录/Table of Contents|

[1]王学文.噬血细胞性淋巴组织细胞增生症的诊断和治疗策略[J].医学研究与战创伤救治(原医学研究生学报),2009,11(01):40-44.
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噬血细胞性淋巴组织细胞增生症的诊断和治疗策略()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第11卷
期数:
2009年01期
页码:
40-44
栏目:
综述
出版日期:
2009-01-20

文章信息/Info

Title:
-
文章编号:
1672-271X(2009)01-0040-05
作者:
王学文
南京军区南京总医院血液病科,江苏南京 210002
Author(s):
-
关键词:
噬血细胞性 淋巴组织细胞增生症诊断治疗指南
Keywords:
-
分类号:
R551.2
DOI:
-
文献标志码:
A
摘要:
HLH-94,为噬血细胞性淋巴组织细胞增生症(hemophagocytic lymphohistiocytosis,HLH)第一个前瞻性国际的治疗研究,诊断是基于5项标准,即发热、脾大、两系血细胞减少、高甘油三酯血症和(或)低纤维蛋白原血症和噬血细胞增生症(hemophagocytosis)。在HLH-2004中引入3项另外的标准;NK细胞活性低或缺如、高铁蛋白血症和高可溶性白细胞介素-2受体(sIL-2R)水平。该8项标准中必须有5项符合,除非有家族史或分子诊断与HLH相一致。HLH-2004化-免疫治疗包括依托泊甙、地塞米松、环孢素A和在选择的病例鞘内注射甲氨喋呤(MTX)和皮质激素。对家族性HLH或分子诊断和严重、持续HLH患者或疾病重新活动患者荐用造血干细胞移植(HSCT)。
Abstract:
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参考文献/References:

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更新日期/Last Update: 2013-11-20