|本期目录/Table of Contents|

[1]景 华,陈文怡,李克良,等.自体造血干细胞回输治疗Ⅰ型糖尿病2例[J].医学研究与战创伤救治(原医学研究生学报),2009,11(03):202-205.
　JING Hua,CHEN Wen-yi,LI Ke-liang,et al.A new method of type 1 diabetes treatment:T lymphocytic series clearance and autologous hematopoietic stem cell transplantation(2 cases analysis)[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2009,11(03):202-205.
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自体造血干细胞回输治疗Ⅰ型糖尿病2例()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第11卷
期数:
2009年03期
页码:
202-205
栏目:
出版日期:
2009-05-20

文章信息/Info

Title:
A new method of type 1 diabetes treatment:T lymphocytic series clearance and autologous hematopoietic stem cell transplantation(2 cases analysis)
文章编号:
1672-271X(2009)03-0202-04
作者:
景 华; 陈文怡; 李克良; 甄二真
解放军第455医院干细胞移植中心，上海 200052
Author(s):
JING Hua; CHEN Wen-yi; LI Ke-liang; XUE Er-zhen
Department of blood stem cell transplantation， the 455th Hospital of PLA，Shanghai 200052,China
关键词:
Ⅰ型糖尿病; 自体造血干细胞移植; T淋巴系统清除
Keywords:
Type 1 diabete; Autologous hematopoietic stem cell transplantation; T lymphocytic series clearance
分类号:
R587.1
DOI:
-
文献标志码:
A
摘要:
目的 观察采用自体造血干细胞回输治疗Ⅰ型糖尿病的临床疗效。方法 提取自体造血干细胞后,行T淋巴系统清除,再行干细胞回输,重建T淋巴系统,以清除原免疫系统对胰 岛细胞的自身免疫反应，恢复胰岛细胞功能。结果 2例患儿分别于干细胞回输后第14天、第20天停用胰岛素,安全出院。随访7个月，各项检查指标均正常。结论 T淋巴系统清除和 自体造血干细胞重建治疗为临床治疗Ⅰ型糖尿病提供了一种新方法,近期疗效好。
Abstract:
Objective To analyze the safety and effect of T lymphocytic series clearance and autologous hematopoietic stem cell transplantation (AHSCT) for type 1 diabetes (T1D). Methods Two newly diagnosed T1D patients were managed by a low dose immuno- suppression regimen followed by AHSCT. Results In the two cases, insulin injection was stopped at 14 days and 20 days respectively after AHSCT, and discharged safely. In 7-month follow-up, their blood glucose level was normal without insulin. Conclusion The clinical outcome showed that low-dose T lymphocytic series clearance and AHSCT were performed safely in two small patients with prolonged insulin independence.

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更新日期/Last Update: 2013-11-20