|本期目录/Table of Contents|

[1]朱元元.硝酸镓和万古霉素抑制表皮葡萄球菌生物膜形成的协同作用[J].医学研究与战创伤救治(原医学研究生学报),2009,11(06):499-501.
　ZHU Yuan-yuan.Inhibition of staphylococcus epidermidis biofilm by a combination of gallium nitrate and vancomycin[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2009,11(06):499-501.
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硝酸镓和万古霉素抑制表皮葡萄球菌生物膜形成的协同作用()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第11卷
期数:
2009年06期
页码:
499-501
栏目:
出版日期:
2009-11-20

文章信息/Info

Title:
Inhibition of staphylococcus epidermidis biofilm by a combination of gallium nitrate and vancomycin
文章编号:
1672-271X(2009)06-0499-03
作者:
朱元元
解放军86医院临床部，安徽当涂 243100
Author(s):
ZHU Yuan-yuan
The 86th Clinical Branch of PLA,Dangtu 243100, Anhui, China
关键词:
万古霉素; 硝酸镓; 葡萄球菌; 生物膜
Keywords:
Vancomycin;  Gallium nitrate;  Sepidermidis;  Biofilm
分类号:
R378.11
DOI:
-
文献标志码:
A
摘要:
目的 观察硝酸镓和万古霉素联合应用对表皮葡萄球菌生物膜形成的影响。方法 采用半定量的分光光度法计算生物膜的形成程度。将低于最小抑菌浓度的古霉素和硝酸镓联合使用，观察它们对表皮葡萄球菌生物膜形成的影响。 结果 硝酸镓(2 μmol/L) 和万古霉素(1μg/ml)联合应用对表皮葡萄球菌生物膜形成的抑制率达到99.9%，明显高于单独使用的效果。结论 硝酸镓可以提高万古霉素对表皮葡萄球菌生物膜形成的抑制效果。
Abstract:
Objective To investigate the inhibition effects of combination of gallium nitrate and vancomycin on the development of staphylococcus epidermidis biofilm.Methods The visible light semiquantitative method was used to measure biofilm value (OD 570).The effect of gallium nitrate and vancomycin on biofilm was evaluated under the minimum drug concentration．Results Gallium nitrate (2 μmol/L) combined with vancomycin (1 μg/ml) inhibited biofilm formation by S.epidermidis (RP 62A) by 99.9%. The inhibit effect was better than that of separately use Gallium nitrate and vancomycin.Conclusion Gallium nitrate can enhance the efficiency of vancomycin in inhibiting biofilm formation by S. epidermidis

参考文献/References:

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相似文献/References:

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　ZHU Yuan-yuan,YANG Shuang-wang,QIU Yan..Evaluation of antimicrobial efficacy of gallium-coated PVC in vitro[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(06):346.[doi:10.3969/j.issn.1672-271X.2014.04.004]

备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-11-20