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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:

第12卷

期数:

2010年01期

页码:

39-41

栏目:

出版日期:

2010-01-20

文章信息/Info

Title:

Optimization of the alcohol extracting technology of Aucklandia lappa for the preparation of Jiangxiang patch by orthogonal test

文章编号:

1672-271X(2010)01-0039-03

作者:

陈 艳¹; 许 茜²; 许景峰¹; 曾 明¹

1. 100700北京，北京军区总医院药理科；2. 200433上海，第二军医大学研究生院

Author(s):

CHEN Yan¹; XU Qian²; XU Jing-feng¹; ZENG Ming¹.

1. Pharmaceutical Department of the General Hospital of Beijing Military Command，Beijing100700, China；2. the Second Military Medical University，Shanghai 200433，China

关键词:

木香; 木香烃内酯; 去氢木香内酯; 提取; 正交设计

Keywords:

Aucklandia lappa; Costunolide; Dehydrocostuslactone; Extraction; Orthogonal test

分类号:

R284.2

DOI:

-

文献标志码:

A

摘要:

目的 优选乙醇回流法提取姜香脐贴中木香药材的最佳工艺。方法 采用正交实验法,对乙醇浓度、料液比(质量:体积)、提取时间和提取次数进行4因素3水平的实验研究，以木香烃内酯和去氢木香内酯含量为考察指标进行数据分析。结果 最佳乙醇回流提取工艺为:用6倍量80%乙醇,回流提取3次,1 h/次。结论 应用该工艺能缩小服用剂量、提高质量，为复方中药经皮控释给药系统新剂型的研制奠定了基础。

Abstract:

Objective To optimize alcohol extract technology from root of Aucklandia lappa for the preparation of Jiangxiang patch. Methods An orthogonal test was used to evaluate the influence factors including the concentration of alcohol, the ratio of alcohol to drug material, extraction times and numbers，and the contents of costunolide and dehydrocostuslactone were used as an index. Results The optimum process consists of dissolved in 6 times of 80% alcohol，extracting for 3 times at 1 hour each time. Conclusion The process may be the base of the preparation of percutaneously controlled-release drug delivery system by reducing the dose and improving the quality.

备注/Memo

备注/Memo:

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更新日期/Last Update: 2010-01-20