|本期目录/Table of Contents|

[1]于苏文,郑秀琴,陈红霞,等.高频重复经颅磁刺激治疗帕金森病临床疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2010,12(02):109-111.
　YU Su-wen,ZHENG Xiu-qin,CHEN Hong-xia,et al.Clinicalal study of treating Parkinsons disease by repetitively transcranial magnetic stimulation[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(02):109-111.
点击复制

高频重复经颅磁刺激治疗帕金森病临床疗效观察()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第12卷
期数:
2010年02期
页码:
109-111
栏目:
出版日期:
2010-03-20

文章信息/Info

Title:
Clinicalal study of treating Parkinsons disease by repetitively transcranial magnetic stimulation
文章编号:
1672-271X(2010)02-0109-03
作者:
于苏文; 郑秀琴; 陈红霞; 崔红霞; 蒋建波
213003 江苏常州，解放军102医院神经内科
Author(s):
YU Su-wen;  ZHENG Xiu-qin;  CHEN Hong-xia;  CUI Hong-xia;  JIANG Jian-bo.
Department of Neurology, 102 Hospital of PLA, Changzhou, Jiangsu 213003, China
关键词:
帕金森病; 重复经颅磁刺激; 运动诱发电位
Keywords:
Parkinsons disease;  repetitively transcranial magnetic stimulation;  motion evoked potentials
分类号:
R742.5
DOI:
-
文献标志码:
A
摘要:
目的 分析高频重复经颅磁刺激(rTMS)对帕金森病(PD)的治疗作用及机理。方法 35例PD患者接受rTMS治疗，采用帕金森病统一评分量表(UPDRS)评分、运动诱发电位(MEP)检查等评价疗效。结果 治疗结束后UPDRS总分及Ⅰ、Ⅱ和Ⅲ分较治疗前均显著降低(均P<0.01)，1分钟平均运动次数显著增加(P<0.01)，行走速度显著增快(P<0.01)，运动诱发电位静息阈值增高、潜伏期及皮质静息期延长(P<0.01)。1个月随访时仍较治疗前有统计学意义(P<0.01)。结论 高频rTMS可以改善近期PD患者的临床症状，提高患者生活质量。
Abstract:
Objective To study the efficacy and safety of treating Parkinsons disease (PD) by high frequency repetitively transcranial magnetic stimulation (rTMS). Methods 35 patients with PD received rTMS therapy. The efficacy was assessed by UPDRS score and motion evoked potentials (MEP). Results In rTMS treatment group, the UPDRS total scores, UPDRSⅠ, Ⅱand Ⅲ were significantly decreased after treatment comparing with that of pre-treatment (all P<0.01). The mean motion numbers of timed motion test were significantly increased (P<0.01). MEP relaxed motion threshold was elevated, cortical latency and cortical silent period were prolonged (P<0.01). There was significant differences after 1 months when follow-up (P<0.01). Conclusion High frequency rTMS may improve the symptoms of the patients with PD and raise their quality of life.

参考文献/References:

[1]Yasuda T, Mochizuki H. Recent advances in cell and gene therapies for Parkinsons disease［J］. Nippon Rinsho, 2009, 67(7):1429-1438.
[2］Elahi B, Elahi B, Chen R. Effect of transcranial magnetic stimulation on Parkinson motor function—systematic review of controlled clinical trials［J］. Mov Disord, 2009, 24(3): 357-363.
[3］Lou JS. Physical and mental fatigue in Parkinsons disease: epidemiology, pathophysiology and treatment［J］. Drugs Aging, 2009, 26(3):195-208.
[4］Lefauaheur JP. Motor cortex dysfunction revealed by cortical excitability studies in Parkinsons disease：influence of antiparkinsonian treatment and cortical stimulation［J］．Clin Neurophysiol, 2005, 116(2):244-253.
[5］Hamada M, Ugawa Y, Tsuji S, et al. High-frequency rTMS over the supplementary motor area for treatment of Parkinson's disease［J］. Mov Disord, 2008, 23(11): 1524-1531.
[6］Khedr EM, Farweez HM, Islam H. Therapeutic effect of repetitive transcranial magnetic stimulation on motor function in Parkinsons disease patients［J］. Eur J Neurol, 2003, 10(5): 567-572.
[7］Boylan LS, Pulhnan SI, Lisanby SH, et al. Repetitive transcranial magnetic stimulation to SMA worsens complex movements in Parkinsons disease［J］. Clin Neurophysiol, 2001, 112(2): 259-264.
[8］Benninger DH, Lomarev M, Wassermann EM,et al. Safety study of 50 Hz repetitive transcranial magnetic stimulation in patients with Parkinsons disease［J］. Clin Neurophysiol, 2009, 120(4): 809-815.

相似文献/References:

[1]胡 晓,王 省,闫福岭,等.帕金森病患者便秘发生情况的临床观察[J].医学研究与战创伤救治(原医学研究生学报),2013,15(04):332.[doi:10.3969/j.issn.1672-271X.2013.04.004]
　HU Xiao,WANG Xing,YAN Fu-ling,et al.Clinic investigation of constipation in Parkinson's disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2013,15(02):332.[doi:10.3969/j.issn.1672-271X.2013.04.004]
[2]曾 志,张国兴,陈基敏.代谢热层像诊断帕金森病5例报告[J].医学研究与战创伤救治(原医学研究生学报),2008,10(01):6.
[3]余志阳,潘士勇,刘清珍,等.丙泊酚对帕金森小鼠黑质多巴胺能神经元凋亡的影响[J].医学研究与战创伤救治(原医学研究生学报),2015,17(04):346.[doi:10.3969/j.issn.1672-271X.2015.04.003]
　YU Zhi-yang,PAN Shi-Yong,LIU Qing-zhen,et al.The effect of propofol on apoptosis of dopaminergic neurons in the substantia nigra of mouse model of Parkinson’s disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(02):346.[doi:10.3969/j.issn.1672-271X.2015.04.003]
[4]张扬,管得宁,徐运.跌倒恐惧对帕金森病患者生活质量的影响[J].医学研究与战创伤救治(原医学研究生学报),2018,20(01):6.[doi:10.3969/j.issn.1672-271X.2018.01.002]
　ZHANG Yang,GUAN De-ning,XU Yun.Impact of fear of falling on quality of life in patients with Parkinson′s disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2018,20(02):6.[doi:10.3969/j.issn.1672-271X.2018.01.002]
[5]杨雅玲,刘华斌,林庆金.枸橼酸坦度螺酮治疗帕金森病异动症的疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2021,23(02):146.[doi:10.3969/j.issn.1672-271X.2021.02.008]
　YANG Ya-ling,LIU Hua-bin,LIN Qing-jin.Therapeutic effect of tandorone citrate on Parkinson’s disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(02):146.[doi:10.3969/j.issn.1672-271X.2021.02.008]
[6]祁娜,王炳臣,徐天朝.重复经颅磁刺激治疗重度抑郁症的效果及对负性自动思维和执行功能的影响[J].医学研究与战创伤救治(原医学研究生学报),2021,23(02):155.[doi:10.3969/j.issn.1672-271X.2021.02.010]
　QI Na,WANG Bing-chen,XU Tian-chao.The effect of rTMS on severe depression and its influence on negative automatic thinking and executive function[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(02):155.[doi:10.3969/j.issn.1672-271X.2021.02.010]
[7]戴为正,吴美娜,傅懋林,等.普拉克索联合高频重复经颅磁刺激治疗早期帕金森病合并抑郁患者的临床疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2021,23(6):592.[doi:10.3969/j.issn.1672-271X.2021.06.007]
　DAI Wei-zheng,WU Mei-na,FU Mao-lin,et al.Observation on clinical effects of pramipexole combined with high-frequency repetitive transcranial magnetic stimulation (rTMS) in the treatment of patients suffered from early Parkinson’s disease (PD) and depression[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(02):592.[doi:10.3969/j.issn.1672-271X.2021.06.007]

备注/Memo

备注/Memo:
-
更新日期/Last Update: 2010-03-20