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[1]周建平,周伟平.大肝癌TACE后肿瘤组织VEGF、αv整合素表达及MVD变化[J].医学研究与战创伤救治(原医学研究生学报),2010,12(03):206-208.
　ZHOU Jian-ping,ZHOU Wei-ping.Expression of VEGF, integrin-αV and MVD in viable residual tumor tissues from large hepatocellular carcinoma after TACE[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(03):206-208.
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大肝癌TACE后肿瘤组织VEGF、αv整合素表达及MVD变化()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第12卷
期数:
2010年03期
页码:
206-208
栏目:
出版日期:
2010-05-20

文章信息/Info

Title:
Expression of VEGF, integrin-αV and MVD in viable residual tumor tissues from large hepatocellular carcinoma after TACE
文章编号:
1672-271X(2010)03-0206-03
作者:
周建平1; 周伟平2
1.315040 浙江宁波，解放军113医院普通外科；2.200438 上海，第二军医大学附属东方肝胆外科医院肝外三科
Author(s):
ZHOU Jian-ping1;  ZHOU Wei-ping2
1.Department of General Surgery,113 Hospital of PLA,Ningbo，Zhejiang 315040,China；2.The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438,China
关键词:
肝细胞癌; 化疗栓塞; 血管内皮生长因子; 整合素; 微血管密度
Keywords:
hepatocellular carcinoma;  chemoembolization;  vascular endothelial growth factor;  Iintegrin;  microvessel density
分类号:
R735.7
DOI:
-
文献标志码:
A
摘要:
目的 观察大肝癌经导管动脉化疗栓塞(TACE)后残存肿瘤组织血管内皮生长因子(VEGF)、αv整合素表达及微血管密度(MVD)变化的意义。方法 96例大肝癌前瞻性分成术前TACE组40例(TACE组)与一期手术组56例(手术组)，用免疫组化方法检测96例手术切除标本肿瘤组织VEGF、αv整合素表达及MVD值。 结果 术前TACE组肿瘤组织VEGF、αv整合素表达免疫反应积分显著高于手术组(分别为P=0.042，P=0.033)，MVD 两者无显著差异(P=0.103)。结论 大肝癌术前TACE促使残存肿瘤组织VEGF及αv整合素的表达增高，有可能促进肿瘤细胞转移。
Abstract:
Objective To investigate the significance of expression of vascular endothelial growth factor (VEGF), integrin-αV and microvessel density (MVD)in viable residual tumor tissues from large hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Methods 96 patients with large HCC were divided to a preoperative TACE group (40 patients) and one-stage operation group (56 patients). Expression of VEGF, integrin-αV and MVD were examined in all viable residual tumor tissues of 96 patients using immunohistochemical staining. Results There were significant differences in the expression levels of VEGF and integrin-αV between preoperative TACE group and one-stage operation group ( P=0.042 and P=0.033). No significant difference was in MVD between two groups ( P=0.103). Conclusion TACE may enhance expression levels of VEGF and integrin-αV in viable residual tumor tissues from large HCC, and may promote cancer cells to metastasize.

参考文献/References:

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[7] Chen QM，Millar HJ,McCabe FL, et al. Alphav integrin-targeted immunoconjugates regress established human tumors in xenograft models[J].Clin Cancer Res,2007,13(12):3689-3695.
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[9] Kim HJ,Chung H,Yoo YG, et al.Inhibitor of DNA binding 1 actvates vascular endothelial growth factor through enhancing the stability and activity of hypoxia-inducible factor-1 alpha[J].Mol Cancer Res,2007,5(4):321-329.
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备注/Memo

备注/Memo:
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更新日期/Last Update: 2010-05-20