|本期目录/Table of Contents|

[1]宋文全,裴士凤,陈力平,等.脂肪酸结合蛋白在心肌损伤中的临床观察[J].医学研究与战创伤救治(原医学研究生学报),2010,12(03):230-231.
　SONG Wen-quan,PEI Shi-feng,CHEN Li-ping,et al.Clinical observation of the role of FABP in the myocardial damage[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(03):230-231.
点击复制

脂肪酸结合蛋白在心肌损伤中的临床观察()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第12卷
期数:
2010年03期
页码:
230-231
栏目:
出版日期:
2010-05-20

文章信息/Info

Title:
Clinical observation of the role of FABP in the myocardial damage
文章编号:
1672-271X(2010)03-0230-02
作者:
宋文全; 裴士凤; 陈力平; 黄雅娟; 林 杰; 任孔健; 王 宇; 周 娜
214044 江苏无锡，解放军101医院检验科
Author(s):
SONG Wen-quan; PEI Shi-feng; CHEN Li-ping; HUANG Ya-juan; LIN Jie; REN Kong-jian; WANG Yu; ZHOU Na
Department of Laboratory,101 Hospital of PLA,Wuxi,Jiangsu 214044,China
关键词:
耐力训练; 脂肪酸结合蛋白; 心肌疾病; 左卡尼汀
Keywords:
endurance training;  fatty acid-binding protein;  myocardial injury;  L-carnitine
分类号:
R542.2
DOI:
-
文献标志码:
A
摘要:
目的 研究耐力训练前后心肌细胞损伤与心型脂肪酸结合蛋白(H-FABP)的关系，并观察左卡尼汀对运动心肌细胞的预防性保护作用。方法 采用酶联免疫吸附试验(ELISA)检测新兵在运动前后及服用左卡尼汀后H-FABP含量。结果 未服药组和服药组间H-FABP含量差异显著(P<0.05)，运动前、运动后即刻和运动后4小时各时间点间比较有统计学意义(P<0.05)。结论 脂肪酸结合蛋白(FABP)可以作为心肌损伤的一种检测指标，左卡尼汀对运动心肌细胞有预防性保护作用。
Abstract:
Objective To investigate the relation between the concentration of heart-fatty acid-binding protein (H-FABP) and myocardial injury before and after endurance training, and to study the protective role of L-carnitine in myocardial cells. Methods The concentrations of H-FABP of recruits were measured before and after exercise, and after taking L-carnitine by ELISA. Results There was a significant difference of H-FABP concentration between untreated group and the treated group (P<0.05).The concentrations were significantly different among groups of pre-training, post-training and 4 hr after training (P<0.05). Conclusion FABP can be a test to detect myocardial damage, and L-carnitine prevents myocardial cells from damage.

参考文献/References:

[1] Tambara K, Fujita M, Miyamoto S, et al.Pericardial fluid level of heart-type cytoplasmic fatty acid-binding protein (H-FABP) is an indicator of severe myocardial ischemia [J].Int J Cardiol, 2004, 93(2-3): 281-284.
[2] Schaap FG, Binas B, Danneberg H, et al.Impaired long chain fatty acid utilization by cardiac myocytes isolated from mice lacking the heart type fatty acid binding protein gene [J].Circ Res, 1999, 85 (4): 329-337.
[3] Seino Y, Tomita Y, Takano T, et al.Office cardiologists cooperative study on whole blood rap id panel tests in patients with suspicious acute myocardial infarction: comparison between heart-type fatty acid-binding protein and troponin T tests [J].Circ J,2004,68 (2): 144-148.
[4] Wunderlich MT, Hanhoff T, Goertler M, et al.Release of brain-type and heart type fatty acid binding proteins in serum after acute ischaemic stroke [J].J Neurol, 2005,252(6): 718-724.
[5] Chan CP, Sanderson JE, Glanz JFC, et al .A superior early myocardial infarction marker human heart type fatty acid binding protein [J].Z Kardiol, 2004,93 (5): 388-397.
[6] 张 鹏,王 前,郑 磊,等.心肌型脂肪酸结合蛋白在急诊胸痛患者中早期诊断急性心肌梗死的作用[J].中华急诊医学杂志,2007,16(3):291-294.
[7] Nemoto S,Aoki M,Dehua C, et al .Effects of carnitine on cardiac function after cardioplegic ischemia in neonatal rabbit hearts[J].Ann Thorac Surg,2001,71(1):254-259.
[8] Beinborn OS, Trusty JM, Jahangir A.Dysrhythmias and the athlete [J].AACN Clin Issues, 2005,15 (3): 432-438.

相似文献/References:

备注/Memo

备注/Memo:
-
更新日期/Last Update: 2010-05-20