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[1]梁 冲,王跃华,李增才,等.氟尿嘧啶缓释剂在老年结肠癌术后疗效的观察[J].医学研究与战创伤救治(原医学研究生学报),2010,12(04):299-301.
　LIANG Chong,WANG Yue-hua,LI Zeng-cai,et al.Research on implanting of 5-Fluorouracil sustained-release to prevent local recurrence of colon carcinomas in the old[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(04):299-301.
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氟尿嘧啶缓释剂在老年结肠癌术后疗效的观察()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第12卷
期数:
2010年04期
页码:
299-301
栏目:
出版日期:
2010-07-20

文章信息/Info

Title:
Research on implanting of 5-Fluorouracil sustained-release to prevent local recurrence of colon carcinomas in the old
文章编号:
1672-271X(2010)04-0299-03
作者:
梁 冲; 王跃华; 李增才; 张 斌; 王 轩; 贾绍昌
210002 江苏南京，解放军81医院肿瘤外科
Author(s):
LIANG Chong; WANG Yue-hua; LI Zeng-cai; ZHANG Bin; WANG Xuan; JIA Shao-chang
Department of Tumor Surgery，81 Hospital of PLA，Nanjing，Jiangsu 210002，China
关键词:
结肠癌; 氟尿嘧啶缓释剂; 局部复发; 远处转移
Keywords:
colon carcinoma;  5-fluorouracil sustained-release;  local recrudescence;  metastasis
分类号:
R735.3+5
DOI:
-
文献标志码:
A
摘要:
目的 探讨术中植入氟尿嘧啶缓释剂(中人氟安)对结肠癌患者术后复发、转移及生存率的影响。方法 回顾性分析75例结肠癌患者进行根治术后，分为观察组(45例):术中植入中人氟安0.55~0.60 g；对照组(30例):仅进行根治术，未进行任何化疗药物植入；两组术后处理相同。结果 观察组的2年生存率优于对照组，观察组的局部复发率低于对照组(P<0.05)；两组远处转移率相比，差异无统计学意义(P＞0.05)。结论 术中植入氟尿嘧啶缓释剂可有效地提高患者生存率，降低术后复发率，且并不增加手术风险及并发症，是一种有效的治疗方法。
Abstract:
Objective To analyze the influence of partially implementation of 5-fluorouracil sustained-release (Zhong Ren Fu An) for colon carcinoma patients during operation on post recrudescence, metastasis and survival rate. Methods 75 colon cancer cases were subjected to PANP and were divided into two groups. The observe group (n=45) was implemented with 0.55 g to 0.60 g of 5-fluorouracil sustained-release during operation, and the control group (n=30) was only treated with PANP swashing with distilled water without any chemotherapeutic treatment. The postoperative treatment of the two groups was the same. The locally recrudescence, metastasis and two years survival rate were retrospectively analyzed. Results The observe group showed a obviously increase in 2 years survival rate and a reduce in local recrudescence (P<0.05). NSS was not statistical significant in metastasis (P>0.05). Conclusion Implementation of 5-fluorouracil sustained-release during operation is an effective therapeutic method which validly increases survival rate and reduces postoperative recrudescence without any additional operation risk and complication.

参考文献/References:

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备注/Memo

备注/Memo:
南京军区科技创新资助项目(08Mb055)
更新日期/Last Update: 2010-07-20