|本期目录/Table of Contents|

[1]张晓云,汪东剑,陈渠通.多脏器功能不全综合征患者血浆降钙素原测定的临床意义[J].医学研究与战创伤救治(原医学研究生学报),2010,12(04):319-321.
　ZHANG Xiao-yun,WANG Dong-jian,CHEN Qu-tong.The clinical significance of detection of plasma procalcitonin in patients with multiple organ dysfunction syndrome[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(04):319-321.
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多脏器功能不全综合征患者血浆降钙素原测定的临床意义()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第12卷
期数:
2010年04期
页码:
319-321
栏目:
出版日期:
2010-07-20

文章信息/Info

Title:
The clinical significance of detection of plasma procalcitonin in patients with multiple organ dysfunction syndrome
文章编号:
1672-271X(2010)04-0319-03
作者:
张晓云;  汪东剑;  陈渠通
335000 江西鹰潭，解放军184医院检验科
Author(s):
ZHANG Xiao-yun;  WANG Dong-jian;  CHEN Qu-tong
Department of Laboratory Diagnosis，184 Hospital of PLA，Yingtan，Jiangxi 335000, China
关键词:
多脏器功能不全综合征; 降钙素原; C反应蛋白
Keywords:
multiple organ dysfunction syndrome;  procalcitonin;  C-reactive protein
分类号:
R446.1
DOI:
-
文献标志码:
A
摘要:
目的 探讨多脏器功能不全综合征(MODS)患者血浆降钙素原(PCT)测定的临床意义。方法 对36例MODS患者进行脓毒症相关脏器衰竭(SOFA)评分，连续观察30 d并记录生存率，于入院后第1 d、3 d、5 d、7 d和15 d行静脉采血，测定血浆PCT及C反应蛋白(CRP)含量。结果 血浆PCT水平和MODS 严重程度呈正相关(r =0.724, P<0.01)，SOFA评分越高，血浆PCT水平越高[SOFA 0～6分PCT 为(0.82±0.23)ng/ml，SOFA 19～24分PCT为(23.61±3.20)ng/ml]；CRP水平与SOFA评分无明显相关(r=0.136, P>0.05)。发病后3 d至15 d内，死亡组患者血浆PCT水平显著高于存活组(P<0.01)，两组患者血浆CRP水平无明显差异。结论 在评价MODS疾病进展及预后方面，血浆PCT测定优于CRP测定。
Abstract:
Objective To explore the clinical value of detection of plasma procalcitonin (PCT) in patients with multiple organ dysfunction syndrome (MODS). Methods The sepsis-related organ failure assessment (SOFA) score was subjected to 36 patients with MODS, and survival rate was evaluated continuously in 30 days. Blood samples were collected at 1, 3, 5, 7 and 15 d after admission, and plasma PCT and CRP were determined. Results There was a significant correlation between plasma PCT and SOFA scores (r=0.724, P<0.01), which higher SOFA scores were associated with higher PCT: SOFA 0－6 to PCT(0.82±0.23) ng/ml and SOFA 19－24 to PCT (23.61±3.20) ng/ml. There was no correlation between plasma CRP and SOFA scores(r=0.136, P>0.05). The plasma PCT of non-surviving patients was significantly higher than that of survivors from 3 to 15d after admission (P<0.01). However, CRP showed no difference between two groups. Conclusion Compared with CRP, the plasma PCT plays a more important role in evaluating the development and prognosis of MODS.

参考文献/References:

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备注/Memo

备注/Memo:
-
更新日期/Last Update: 2010-07-20