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[1]余海鹰,高志勤,金梅,等.经颅磁刺激对精神分裂症患者催乳素水平的影响[J].医学研究与战创伤救治(原医学研究生学报),2010,12(06):512-514.
　YU Hai-ying,GAO Zhi-qin,JIN Mei,et al.Effect of transcranial magnetic stimulation on level of luteotropin in patients with schizophrenia[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(06):512-514.
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经颅磁刺激对精神分裂症患者催乳素水平的影响()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第12卷
期数:
2010年06期
页码:
512-514
栏目:
出版日期:
2010-11-20

文章信息/Info

Title:
Effect of transcranial magnetic stimulation on level of luteotropin in patients with schizophrenia
文章编号:
1672-271X(2010)06-0512-03
作者:
余海鹰; 高志勤; 金梅; 孙剑; 丁松柏; 赵彬; 邱旭萍; 仲爱芳; 王焕林
213003 江苏常州，解放军102医院精神科
Author(s):
YU Hai-ying;  GAO Zhi-qin;  JIN Mei;  SUN Jian; DING Song-bai; ZHAO Bin; QIU Xu-ping; ZHONG Ai-fang; WANG Huan-lin.
The Mental Department, 102 Hospital of PLA, Changzhou, Jiangsu 213003，China
关键词:
精神分裂症; 高催乳素血症; 低频重复经颅磁刺激; 利哌立酮
Keywords:
schizophrenia;  hyperprolactinemia;  slow repetitive transcranial magnetic stimulation;  risperidone
分类号:
R749.3
DOI:
-
文献标志码:
A
摘要:
目的探讨经颅磁刺激(rTMS)治疗抗精神病药所致高催乳素血症的疗效及安全性。方法将61例利培酮所致高催乳素血症的慢性精神分裂症随机分为两组，研究组(31例)予以低频rTMS刺激，对照组(30例)以假rTMS刺激治疗；并观察血清催乳素、PANSS表、17项汉密尔顿抑郁量表的情况。结果①研究组rTMS刺激后PRL水平[(27.9±7.1)μg/L]较治疗前[(101.5±41.2)μg/L]下降，差异有统计学意义(P＜0.01)；对照组差异无统计学意义(P＞0.05)；研究组治疗1个月后复测PRL[(96.7±38.3)μg/L]，已恢复至治疗前水平(P＞0.05)。②治疗前后两组患者PANSS及HAMD17评分变化均无统计学意义(P均＞0.05)。结论低频rTMS治疗可使慢性精神分裂症患者血清高催乳素短期下降。
Abstract:
ObjectiveTo explore the efficacy and tolerability of slow repetitive transcranial magnetic stimulation (rTMS) on the treatment of hyperprolactinemia by antipsychotic. MethodsSixty-one chronic schizophrenia patients with hyperprolactinemia by risperidone were randomly assigned to active slow rTMS group (31 cases) and control group (30 cases). All the patients were examined with serum prolactin (PRL), Positive and Negative Syndrom Scale (PANSS) and 17-item Hamilton Depression Rating Scale (HAMD17) before and after rTMS. ResultsThe serum PRL was lower after the treatment (27.9±7.1 μg/L) than before (101.5±41.2 μg/L) in rTMS group (P<0.01) while there was no significant difference in control group (P>0.05). After 1month follow-up, the PRL in rTMS group recuperated to baseline levels (P>0.05). The PANSS and the HAMD17 score were not significantly different after rTMS between two groups (P>0.05) . ConclusionThe results indicated that short-term slow rTMS is effective and safe in the treatment of hyperprolactinemia by risperidone.

参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2010-11-20