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[1]仲爱芳,王晓辉,何益民,等.共患糖尿病的抑郁症患者皮质醇分泌节律的研究[J].医学研究与战创伤救治(原医学研究生学报),2011,13(02):140-142.
　ZHONG Ai-fang,WANG Xiao-hui,HE Yi-min,et al.The diurnal rhythm of cortisol secretion in patients with comorbidity of depression and diabetes: a clinical control study[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(02):140-142.
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共患糖尿病的抑郁症患者皮质醇分泌节律的研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年02期
页码:
140-142
栏目:
出版日期:
2011-03-20

文章信息/Info

Title:
The diurnal rhythm of cortisol secretion in patients with comorbidity of depression and diabetes: a clinical control study
文章编号:
1672-271X(2011)02-0140-03
作者:
仲爱芳; 王晓辉; 何益民; 宋梓祥; 陈 琪; 徐乐平
213003 江苏常州，解放军102医院检验科
Author(s):
ZHONG Ai-fang ; WANG Xiao-hui ; HE Yi-min; SONG Zi-xiang;  CHEN Qi;  XU Le-ping
Department of Clinical Laboratory, 102 Hospital of PLA, Changzhou, Jiangsu 213003,China
关键词:
糖尿病; 抑郁症; 皮质醇; 分泌节律
Keywords:
diabetes;  depression;  cortisol;  rhythm of cortisol secretion
分类号:
R587.1
DOI:
-
文献标志码:
A
摘要:
目的 探讨同时伴有糖尿病的抑郁症患者皮质醇分泌节律的特点，及其在抑郁症患者所发生的糖尿病病理机制中的意义。方法 确诊糖尿病的抑郁症30例(观察组)测定8∶00、16∶00、24∶00血浆皮质醇浓度，同时测定空腹血糖、糖负荷后2 h血糖，并与正常糖代谢的抑郁症30例(对照组)进行对照。结果 ①观察组8∶00、16∶00、24∶00血浆皮质醇浓度分别为(607±269)nmol／L、(416±178)nmol／L、(376±264)nmol／L，显著高于对照组(485±178)nmol／L、(290±154)nmol／L、(173±117)nmol／L，差异有统计学意义(P均<0.05)。②观察组皮质醇分泌节律消失者为73.3%，显著高于对照组的46.7%(P<0.05)。③观察组8∶00、24∶00的血浆皮质醇浓度与空腹血糖值正相关(r值分别为0.338、0.418，P<0.05)。结论 下丘脑-垂体-肾上腺轴功能紊乱可能是抑郁患者产生糖尿病的重要机制之一。
Abstract:
Objective To study the characteristics of diurnal rhythm of cortisol secretion in depression patients with diabetes. Methods Two groups including depressed patients with newly diagnosed diabetes (case group, n=30), depressed patients with normal glucose metabolism (control group, n=30), undertook the assessment of rhythm in cortisol secretion at 3 time point (8:00，16:00，24:00) and fasting plasma glucose, 2h plasma glucose after 75g glucose loading measurement before administration. Results It was showed that the plasma cortisol levels in test group at time point of 8:00， 16:00， 24:00 were significantly higher than those in control group [(607±269)nmol/L vs (485±178)nmol/L;(416±178)nmol/L vs (290±154)nmol/L;(376±264)nmol/L vs (173±117) nmol/L; all P＜0.05].The loss of normal diurnal rhythm of cortisol secretion were significantly more often in case group than in control group (73.3％ vs 46.7％, P＜0.05). Plasma cortisol levels at 8:00, 24:00 were positively correlated with fasting plasma glucose in test group (r=0.338, 0.418; both P＜0.05). Conclusion Depressed patients with diabetes have higher plasma and abnormal rhythm of cortisol secretion cases. This may play a very important role in the pathomechanism of diabetes in depression.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2011-03-20