|本期目录/Table of Contents|

[1]蔡大勇,王 坚.女性中枢性甲状腺功能减退的临床分析[J].医学研究与战创伤救治(原医学研究生学报),2011,13(03):197-199.
　CAI Da-yong,WANG Jian..Analysis of etiological factors in 35 female patients with central hypothyroidism[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(03):197-199.
点击复制

女性中枢性甲状腺功能减退的临床分析()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年03期
页码:
197-199
栏目:
出版日期:
2011-05-20

文章信息/Info

Title:
Analysis of etiological factors in 35 female patients with central hypothyroidism
文章编号:
1672-271X(2011)03-0197-03
作者:
蔡大勇; 王 坚
210002 江苏南京，第二军医大学临床医学院、南京军区总医院内分泌科
Author(s):
CAI Da-yong;  WANG Jian.
Department of Endocrinology, the Second Military Medical University, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing,Jiangsu 210002, China
关键词:
甲状腺功能减退; 中枢性; 席汉综合征
Keywords:
central hypothyroidism;  etiology;  Sheehan syndrome
分类号:
R581.2
DOI:
-
文献标志码:
A
摘要:
目的 探讨女性中枢性甲状腺功能减退的临床特点。方法 回顾性分析甲状腺功能减退患者的临床症状、体征及实验室检查的结果，并进行统计分析。结果 女性患者中，席汉综合征(Sheehan综合征)占40.0%(14/35)，下丘脑-垂体处占位性病变占28.6%(10/35)，鞍区手术和放射照射占25.7%(9/35)，缺血性脑病和特发性中枢性甲状腺功能减退仅占5.7%(2/35)。女性患者促甲状腺激素水平下降较男性患者显著，男性皮质醇、睾酮、孕酮水平下降较女性显著。 结论 Sheehan综合征是女性中枢性甲状腺功能减退最多见的病因；女性甲减患者合并Sheehan综合征、鞍区和鞍上占位性病变、颅脑手术和(或)放疗史、其他下丘脑-垂体轴异常表现、难以纠正的贫血以及三酰甘油异常增高，应考虑诊断中枢性甲减。
Abstract:
Objective To analyze the clinical features in females with central hypothyroidism. Methods The clinical symptoms, signs and laboratory results of all the patients were analyzed retrospectively. Results 40.0% of these cases were caused by Sheehan syndrome, 28.6% were by hypothalamus-pituitary mass lesions, 25.7% were by surgery and radiation therapy, and only 5.7% were by ischemic encephalopathy and idiopathic central hypothyroidism. FSH levels of females decreased more than those of males, while cortisol, testosterone, progesterone levels of males decreased more than those of females. Conclusion Sheehan syndrome was the most common cause of central hypothyroidism in females, and some clinical manifestations were significantly different from males.

参考文献/References:

[1]Lania A,Persani L,Beck-Peccoz P.Central hypothyroidism[J].Pituitary, 2008,11(2):181-186.
[2]王 坚.中枢性甲状腺机能减退诊断探讨—附76例临床实验研究[J].天津医药, 1997，25(1):4-7.
[3]Gokalp D,Tuzcu A,Bahceci M, et al.Sheehan’s syndrome as a rare cause of anaemia secondary to hypopituitarism[J].Ann Hematol, 2009,88(5):405-410.
[4]师 敏, 吴 疆, 任秀英, 等.席汉综合征42例临床分析[J].农垦医学, 2006,28(4):272-373.
[5]Schneider HJ,Aimaretti G,Kreitschmann-Andermahr I,et al.Hypopituitarism[J].Lancet, 2007,369(9571):1461-1470.
[6]Bhandare N,Kennedy L,Malyapa RS, et al.Primary and central hypothyroidism after radiotherapy for head-and-neck tumors[J].Int J Radiat Oncol Biol Phys, 2007，68(4):1131-1139.
[7]Kong DS,Lee JI,Lim dH, et al.The efficacy of fractionated radiotherapy and stereotactic radiosurgery for pituitary adenomas: long-term results of 125 consecutive patients treated in a single institution[J].Cancer,2007,110(4):854-860.
[8]Constine LS,Woolf PD,Cann D, et al.Hypothalamic-pituitary d-ysfunction after radiation for brain tumors[J].N Engl J Med, 1993,328(2):87-94.
[9]岳连虎, 韩 波.甲状腺功能异常患者的性激素水平变化分析[J].中国误诊学杂志, 2009,9(10):2293-2294.
[10]Nishioka H, Haraoka J.Hypopituitarism and anemia: effect of replacement therapy with hydrocortisone and/or levothyroxine[J].J Endocrinol Invest, 2005,28(6):528-533.
[11]蒋天如.以贫血为主要表现的甲状腺功能减退症1例[J].东南国防医药, 2005,7(4):303.

相似文献/References:

备注/Memo

备注/Memo:
国家自然科学基金资助项目(81070626)
更新日期/Last Update: 2011-05-20