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[1]伏杭江,彭巧玲,严 斌,等.儿童交替性偏瘫6例回顾性分析[J].医学研究与战创伤救治(原医学研究生学报),2011,13(04):319-320.
　FU Hang-jiang,PENG Qiao-ling,YAN Bin,et al.Clinical analysis of 6 cases with alternating hemiplegia of childhood[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(04):319-320.
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儿童交替性偏瘫6例回顾性分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年04期
页码:
319-320
栏目:
出版日期:
2011-07-20

文章信息/Info

Title:
Clinical analysis of 6 cases with alternating hemiplegia of childhood
文章编号:
1672-271X(2011)04-0319-02
作者:
伏杭江1; 彭巧玲2; 严 斌2; 段立晖2; 卢孝鹏3
210002 江苏南京，南京军区南京总医院，1.干部保健科，2.神经内科；3.210008 江苏南京,南京医科大学附属南京儿童医院神经内科
Author(s):
FU Hang-jiang1; PENG Qiao-ling2; YAN Bin2; DUAN li-hui2; LU Xiao-peng3.
1.Department of Cadre Sanitarian,2.Department of Neurology,Nanjing General Hospital of Nanjing Military Command，PLA,Nanjing,Jiangsu 210002,China；3.Department of Neurology,Nanjing Childrens Hospital of Nanjing Medical University,Nanjing,Jiangsu 210008,China
关键词:
交替性偏瘫;  氟桂利嗪; 托吡酯
Keywords:
alternating hemiplegia;  flunarizine;  topiramate
分类号:
R742.3
DOI:
-
文献标志码:
A
摘要:
目的 探讨儿童交替性偏瘫(AHC)的临床特点、诊断、鉴别诊断和治疗方法。方法 对6例AHC患儿的临床资料进行分析。结果 6例患儿均在出生后18个月内发病，呈反复发作、间隔时间不定的交替性偏瘫，进行性认知功能减退；或伴有言语障碍、斜视和眼球震颤以及瘫侧肢体的舞蹈样不自主徐动。6例使用氟桂利嗪治疗后，1例4年内未见发作，1例2年内有1次发作，其中4例改用托吡酯后发作频率明显减少持续时间明显缩短。结论 该病的主要特征为出生后18个月内出现的反复发作的交替性偏瘫，伴有认知功能障碍和锥体外系症状。氟桂利嗪和托吡酯对AHC都有效。
Abstract:
Objective To explore the clinical features and treatment of alternating hemiplegia of childhood (AHC).Methods The clinical data of 6 cases with AHC were retrospectively analyzed.Results The symptoms of AHC were characterized by onset before 18 months of age,repeated episodes of hemiplegia alternating sides or both sides of the body,with other paroxysmal clinical signs,including ocular abnormalities,dystonic posturing,choreoathetoid movements,tonic spells,and progressive cognitive impairment.Two of the six children had ocular palsies.Two of the six children had tonic spells.Two of the six children had choreoathetoid movements.The six children were treated with flunarizine,one of whom had completely ceased episodes in four year,one of whom had completely ceased episodes in two year.The four of whom were treated with topiramate,The children showed reduced frequency and duration of the hemiplegic attacks.Conclusion AHC occurs before 18 months of age,accompanied with paroxysmal signs and cognitive impairment.Flunarizine and topiramate may be effective in treating AHC.

参考文献/References:

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备注/Memo:
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更新日期/Last Update: 2011-07-20