|本期目录/Table of Contents|

[1]施祝良,张学渊,黄 洁.术后鼻黏膜组织嗜酸性粒细胞阳离子蛋白及趋化因子的变化[J].医学研究与战创伤救治(原医学研究生学报),2011,13(05):419-421.
　SHI Zhu-liang,ZHANG Xue-yuan,Huang-jie.Evaluation of expression of cationic protein and eotaxin of eosinophils in sinus cavity mucosa after endoscopic sinus surgery[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(05):419-421.
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术后鼻黏膜组织嗜酸性粒细胞阳离子蛋白及趋化因子的变化()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年05期
页码:
419-421
栏目:
出版日期:
2011-09-20

文章信息/Info

Title:
Evaluation of expression of cationic protein and eotaxin of eosinophils in sinus cavity mucosa after endoscopic sinus surgery
文章编号:
1672-271X(2011)05-0419-03
作者:
施祝良; 张学渊; 黄 洁
315040 浙江宁波，解放军113医院耳鼻咽喉科
Author(s):
SHI Zhu-liang; ZHANG Xue-yuan; Huang-jie
Department of Otorhinolaryngology，113 Hospital of PLA,Ningbo,Zhejiang 315040,China
关键词:
嗜酸性粒细胞阳离子蛋白; 嗜酸性粒细胞趋化因子; 细胞因子; 鼻内镜手术; 鼻窦炎
Keywords:
eosinophilcationic protein;  eotaxin;  eosinophil;  functional endoscopic sinus surgery (FESS);  sinusitis
分类号:
R765.21
DOI:
-
文献标志码:
A
摘要:
目的 观察嗜酸性粒细胞阳离子蛋白(ECP)及嗜酸性粒细胞趋化因子(eotaxin)在鼻内镜术后鼻腔黏膜转归过程中表达的变化，并分析两者的相关性，探讨嗜酸性粒细胞聚集活化对鼻内镜术后鼻腔黏膜转归的影响。方法 采用酶免疫荧光分析技术检测ECP，采用Western-blot技术检测eotaxin,分析ECP及eotaxin在慢性鼻-鼻窦炎患者行鼻内镜术后鼻腔黏膜转归过程中的表达变化。结果 ECP及eotaxin蛋白在正常鼻黏膜中少量表达，术后随时间呈现如下变化规律:①术后1～2周较术前明显降低；②术后4～6周达高峰，基本恢复至术前水平；③术后10～12周回落，接近于术后1～2周水平。④ eotaxin和ECP在鼻内镜术后鼻腔黏膜转归过程中呈正相关关系，相关系数为0.719。结论 eotaxin、ECP在鼻内镜术后鼻腔黏膜的表达动态变化与鼻腔病变的转归过程相对应。
Abstract:
Objective To observe the expression of eotaxin and ECP during different phrases of process of mucosa in sinus cavity after endoscopic sinus surgery,and investigate the roles of eosinophils in the pathogenesis of CRS and the clinical mucosa recovery. Methods The expression of eotaxin and ECP during different phrase of process of mucosa in sinus cavity wre determined by using Western-blot and enzyme-fluoroimmunoassay respectively .The datas were analyzed with ANOVA and linear correlation with SPSS 11.0 software. Results From the first to second week after surgery,there was a significant decrease in secretion of eotaxin and ECP. The secretion of eotaxin and ECP rose back at the 4 to 6 week after operation,and tended to the level of the first to second at the 10 to 12 week after operation. Eotaxin was positively correlated to the secretion of ECP during the mucosa recovery in operative cavity (r=0.719,P<0.01). Conclusion Dynamic expressions of eotaxin and ECP in the operative cavity mucosa are correspondence to the clinical mucosa recovery. Our data demonstrate the gathering and acting of eosinophils related to the edema and polyoid hypertension closely.

参考文献/References:

[1]中华耳鼻咽喉头颈外科杂志编委会,中华医学会耳鼻咽喉头颈外科学分会鼻科学组.慢性鼻-鼻窦炎诊断和治疗指南[J].中国临床医生,2010,38(4):73-74.
[2]施祝良，张学渊.嗜酸性粒细胞阳离子蛋白在鼻内镜术鼻腔黏膜转归过程中的表达[J].临床耳鼻咽喉科杂志,2005,19(14):627-628.
[3]王鹏举,沈 莹.慢性鼻窦炎患者手术前后血清表皮生长因子含量的变化[J].临床耳鼻咽喉头颈外科杂志,2011,25(2):49-50.
[4]Behnecke A,Mayr S,Schick B.Evaluation of ECP release from intact tissue biopsies from patients with nasal polyps[J].Inflam Res,2008,57(1):65-66.
[5]Akuthota P,Wang HB,Spencer LA.Immunoregulatory roles of eosinophils a new look at a familiar cell[J].Clin Exp Allergy,2008,38(8):1254-1263.
[6]袁 晖,杨蓓蓓,魏红权.鼻息肉组织中杯状细胞密度与术后疗效的相关性分析[J].临床耳鼻咽喉头颈外科杂志,2008,22(11):518-519.
[7]Sun DI,Joo YH,Auo HJ.Clinical significance of eosinophilic cationic protein levels in nasal secretions of patients with nasal polyposis[J].Eur Arch Oto-rhino-laryngol,2009,266(7):981-986.
[8]张 勋,胡丽敏.变应性鼻及鼻窦炎相关细胞及细胞因子[J].国际耳鼻咽喉头颈外科杂志,2007,31(4):235-237.
[9]夏忠芳,孔维佳,乐建新，等.鼻息肉组织及上皮细胞的形态学特征与嗜酸性粒细胞阳离子蛋白的表达[J].临床耳鼻咽喉头颈外科杂志,2008,22(17):787-789.
[10]关志华,陈立萍,黄超洋,等.鼻后滴漏综合征治疗的临床研究 [J].东南国防医药,2011,13(3):234-235.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2011-09-20