|本期目录/Table of Contents|

[1]肖明生,许宏华.美金刚联合尼莫地平治疗高龄老年中重度血管性痴呆临床研究[J].医学研究与战创伤救治(原医学研究生学报),2011,13(06):515-517.
　XIAO Ming-sheng,XU Hong-hua.Clinical research of memantine combined with nimodipine on senile elderly vascular dementia[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(06):515-517.
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美金刚联合尼莫地平治疗高龄老年中重度血管性痴呆临床研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年06期
页码:
515-517
栏目:
出版日期:
2011-11-20

文章信息/Info

Title:
Clinical research of memantine combined with nimodipine on senile elderly vascular dementia
文章编号:
1672-271X(2011)06-0515-03
作者:
肖明生; 许宏华
330002 江西南昌，解放军94医院干部病房
Author(s):
XIAO Ming-sheng; XU Hong-hua
Department of Cadre Ward,94 Hospital of PLA,Nanchang,Jiangxi 330002,China
关键词:
美金刚; 尼莫地平; 血管性痴呆; 高龄老年
Keywords:
memantine;  nimodipine;  vascular dementia;  senile elderly patients
分类号:
R743.9
DOI:
-
文献标志码:
A
摘要:
目的 探讨美金刚联合尼莫地平对高龄老年中重度血管性痴呆患者认知功能和行为能力的疗效及安全性。方法 将50例高龄老年血管性痴呆患者，简易精神状态检查表(MMSE)分数介于7至20之间，随机分为3个组,在治疗前和治疗12周后进行MMSE、日常生活活动能力量表(ADL)和临床痴呆评定量表(CDR)的评分并比较三组的评分结果，同时观察不良反应。结果 单用美金刚治疗组治疗后MMSE评分为(18.7±4.5)分，ADL评分为(30.7±11.5)分，较对照组[分别为(15.9±4.6)分和(34.9±11.8)分]有显著改善(P<0.05)；联合用药组治疗后MMSE评分为(21.2±3.9)分,ADL评分为(26.5±10.6)分,较单用美金刚治疗组有显著改善(P<0.05)，三组不良反应发生率差异没有统计学意义(P＞0.05)。结论 美金刚能有效改善高龄老年中重度血管性痴呆患者的认知功能及日常生活能力,与尼莫地平联合治疗效果更好，并有较高的安全性。
Abstract:
Objective To explore the clinical efficacy and safety of memantine combined with nimodipine in improving cognitive function and behavioral capacity in senile elderly vascular dementia patients. Methods Fifty senile elderly vascular dementia patients with Minimental State Examination(MMSE)scores between 7 and 20 were randomly divided into 3 groups. MMSE,Activit of Daily Livings Scale (ADL) and Clinical Dementia Rating Scale (CDR) scores were assessed before treatment and after 12 weeks of treatment. A comparative study was made to evalate the curative effects and side effects between the 3 groups. Results MMSE and ADL scores of memantine group (18.7±4.5,30.7±11.5,respectively) improved significantly when compared with control group (15.9±4.6,34.9±11.8,respectively),and the difference was significant (P<0.05). There was a significant difference in MMSE and ADL scores between combined group (21.2±3.9,26.5±10.6,respectively) and memantine group (P<0.05). The incidence of adverse reactions showed no difference between 3 groups (P＞0.05). Conclusion Memantine can effectively improve the cognitive function and daily living skills in senile elderly vascular dementia patients. Its combination with nimodipine is superior to its single use with a higher safety.

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更新日期/Last Update: 2011-11-20