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[1]祝春华,舒荣文,刘志军,等.替米沙坦对部分中老年高血压病胰岛素抵抗及糖、脂代谢的影响[J].医学研究与战创伤救治(原医学研究生学报),2012,14(03):230-232.
　ZHU Chun-hua,SHU Rong-wen,LIU Zhi-jun,et al.Effect of telmisartan on insulin resistance and glucose and lipid metabolism in the middle-aged and elderly patients with hypertension[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(03):230-232.
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替米沙坦对部分中老年高血压病胰岛素抵抗及糖、脂代谢的影响()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第14卷
期数:
2012年03期
页码:
230-232
栏目:
出版日期:
2012-05-22

文章信息/Info

Title:
Effect of telmisartan on insulin resistance and glucose and lipid metabolism in the middle-aged and elderly patients with hypertension
文章编号:
1672-271X(2012)03-0230-03
作者:
祝春华1; 舒荣文2; 刘志军1; 张严高1; 王留军1
1.310007 浙江杭州，南京军区杭州疗养院；2.210002 江苏南京，南京军区总医院干部保健科
Author(s):
ZHU Chun-hua1; SHU Rong-wen2; LIU Zhi-jun1; ZHANG Yan-gao1; WANG Liu-Jun1.
1.Hangzhou Sanatorium of Nanjing Military Command,Hangzhou,Zhejiang 310007,China;2.Department of Senile Medicine,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing,Jiangsu 210002,China
关键词:
替米沙坦; 高血压病; 胰岛素抵抗; 代谢
Keywords:
telmisartan;  hypertension;  insulin resistance;  metabolism
分类号:
R544.1
DOI:
-
文献标志码:
A
摘要:
目的 观察替米沙坦对部分中老年高血压病胰岛素抵抗及糖、脂代谢的影响。方法 选择中老年高血压病80例(年龄≥60岁)，口服替米沙坦治疗8周。治疗前、后观察患者的体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、餐后2小时血糖(2hPG)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)。结果 替米沙坦治疗后，患者的BMI、SBP 、DBP、FPG、2hPG、TG、TC、LDL-C、FINS、HOMA-IR均显著下降(P<0.05)，HDL-C显著提高(P<0.05)。结论 替米沙坦除了有较好的降压效果，还可以改善中老年高血压病患者胰岛素抵抗及糖、脂代谢异常，从而预防心脑血管疾病的发生。
Abstract:
Objective To observe the effect of telmisartan on insulin resistance and glucose and lipid metabolism in the middle-aged and elderly patients with hypertension.Methods The middle-aged and elderly patients with hypertension (over 60 years old,n=80)were selected and given telmisartan for 8 weeks.Their body mass index (BMI),systolic blood pressure (SBP),diastolic blood pressure (DBP),fasting plasma glucose (FPG),2 hours postprandial glucose (2hPG),triglycerides (TG),total cholesterol (TC),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),fasting insulin (FINS), and homeostasis model assessment of insulin resistance (HOMA-IR)were observed before and after treatment.Results The patients，BMI，SBP，DBP，FPG，2hPG，TG，TC，LDL-C，FINS，HOMA-IR were decreased significantly after treatment (P<0.05),while the level of high-density lipoprotein cholesterol (HDL-C)were increased significantly (P<0.05).Conclusion Besides the better antihypertensive effect,telmisartan can improved insulin resistance and glucose and lipid metabolism,in order to prevent cardiovascular and cerebrovascular diseases.

参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2012-05-20