|本期目录/Table of Contents|

[1]郑佳鹏,丁真奇,孟加榕,等.亚甲蓝兔膝关节腔内注射的安全性研究[J].医学研究与战创伤救治(原医学研究生学报),2013,15(03):228-230.[doi:10.3969/j.issn.1672-271X.2013.03.007]
　ZHENG Jia-peng,DING Zhen-qi,MENG Jia-rong,et al.Experimental study of methylene blue intraarticular injection on knee joint of rabbit[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2013,15(03):228-230.[doi:10.3969/j.issn.1672-271X.2013.03.007]
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亚甲蓝兔膝关节腔内注射的安全性研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第15卷
期数:
2013年03期
页码:
228-230
栏目:
出版日期:
2013-03-30

文章信息/Info

Title:
Experimental study of methylene blue intraarticular injection on knee joint of rabbit
作者:
郑佳鹏; 丁真奇; 孟加榕; 刘良田
363000 福建漳州,解放军175医院(厦门大学附属东南医院)全军骨科中心
Author(s):
ZHENG Jia-peng; DING Zhen-qi; MENG Jia-rong; LIU Liang-tian
Department of Orthopaedic,175 Hospital of PLA,Zhangzhou,Fujian 363000,China
关键词:
亚甲蓝; 安全性; 关节腔内; 注射
Keywords:
methylene blue;  safety;  intraarticular;  injection
分类号:
R965.1
DOI:
10.3969/j.issn.1672-271X.2013.03.007
文献标志码:
A
摘要:
目的 观察不同剂量亚甲蓝兔膝关节腔内注射后对兔全身及局部的影响。方法 将48只兔随机分成0.5 mg/kg组、1 mg/kg组、2 mg/kg组和对照组,每组12只,分别按0.5、1、2 mg/kg的剂量向膝关节腔内注射亚甲蓝溶液和等量0.9%氯化钠,观察各组兔注射前及注射后不同时期血液学参数、血液生化指标及注射后12周膝关节内组织病理学变化。结果 与对照组相比,不同剂量亚甲蓝组兔全身情况、血液学参数、血液生化指标无明显改变,≤1 mg/kg剂量亚甲蓝兔膝关节腔内注射对兔关节软骨、滑膜、交叉韧带、半月板无明显病理性改变。结论 亚甲蓝≤1 mg/kg剂量兔膝关节腔内注射对兔的全身及局部无明显毒性作用。
Abstract:
Objective To study the safety of the methylene blue(MB)that intraarticular injected on knee joint of rabbit limb.Methods 48 rabbits were randomly divided into experimental group and control group.Experimental group were received 0.5 mg/kg,1 mg/kg,2 mg/kg MB by intraarticular injection on knee joint and control group received the same amount of physiologic saline.Blood test was examined before and after injection.Pathological examination of articular tissue was taken after sacrificed(12 weeks after injection).Results Compared to control group,blood tests showed no changes in experimental group,and there were no significant difference of articular tissue when the dosage of MB was ≤1 mg/kg.Conclusion The dosage of MB ≤1 mg/kg intraarticular injection on knee joint of rabbit is no significant toxicity and safe.

参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-05-20