|本期目录/Table of Contents|

[1]汪芳裕.溃疡性结肠炎相关大肠癌研究进展[J].医学研究与战创伤救治(原医学研究生学报),2013,15(04):376-380.[doi:10.3969/j.issn.1672-271X.2013.04.019]
点击复制

溃疡性结肠炎相关大肠癌研究进展()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第15卷
期数:
2013年04期
页码:
376-380
栏目:
综述
出版日期:
2013-08-05

文章信息/Info

Title:
-
作者:
汪芳裕
210002 江苏南京,南京军区南京总医院消化内科
Author(s):
-
关键词:
溃疡性结肠炎相关大肠癌 氧化应激损伤 临床监测 化学预防
Keywords:
-
分类号:
R735.3
DOI:
10.3969/j.issn.1672-271X.2013.04.019
文献标志码:
A
摘要:
溃疡性结肠炎相关大肠癌指的是在溃疡性结肠炎(ulcerative colitis,UC)背景下发生的大肠癌,UC患者大肠癌的发生率明显高于一般人群,而且随病程的延长而上升。慢性炎症刺激通过氧化应激造成肠黏膜损伤,引起细胞增殖调控的相关基因的突变和表观遗传改变,从而导致结肠上皮细胞增殖和转运加速,最终可发生异型增生和癌变。对长期UC患者必须进行大肠镜监测,若在炎症区域发现异型增生的息肉或腺瘤样病变可将其完整切除,非腺瘤样重度异型增生和广泛的异型增生病变则应考虑手术切除结肠。5-氨基水杨酸类药物通过减轻炎症可预防癌变发生。
Abstract:
-

参考文献/References:

[1] Bernstein CN,Fried M,Krabshuis JH,et al.World Gastroenterology Organization Practice Guidelines for the Diagnosis and Management of IBD in 2010[J].Inflamm Bowel Dis,2010,16(1):112–124.
[2] 中华医学会消化病学分会炎症性肠病学组.炎症性肠病诊断与治疗的共识意见[J].中华内科杂志,2012,12(8):818-831.
[3] Eaden JA,Abrams KR,Mayberry JF.The risk of colorectal cancer in ulcerative colitis:a meta-analysis[J].Gut,2001,48(4):526-535.
[4] Rizzo A,Pallone F,Monteleone G,et al.Intestinal inflammation and colorectal cancer:a double-edged sword[J]World J Gastroenterol,2011,17(26):3092-3100.
[5] Chambers WM,Warren BF,Jewell DP,et al.Cancer surveillance in ulcerative colitis[J].Br J Surg,2005,92(8):928-936.
[6] Ullman TA,Itzkowitz SH.Intestinal Inflammation and Cancer[J].Gastroenterology,2011,140(6):1807-1816.
[7] Kanneganti M,Mino-Kenudson M,Mizoguchi E.Animal models of colitis-associated carcinogenesis[J].J Biomed Biotechnol,2011:1-22.
[8] Chu FF,Esworthy RS,Chu PG,et al.Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes[J].Cancer Res,2004,64(3):962-968.
[9] Popivanova BK,Kostadinova FI,Furuichi K,et al.Blockade of a chemokine,CCL2,reduces chronic colitis-associated carcinogenesis in mice[J].Cancer Res,2009,69(19):7884-7892.
[10] Bongers G,Maussang D,Muniz LR,et al.The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice[J].J Clin Invest,2010,120(11):3969-3978.
[11] Vetrano S,Borroni EM,Sarukhan A,et al.The lymphatic system controls intestinal inflammation and inflammation-associated Colon Cancer through the chemokine decoy receptor D6[J].Gut,2010,59(2):197-206.
[12] Mowat C,Cole A,Windsor A,et al.Guidelines for the management of inflammatory bowel disease in adults[J].Gut,2011,60(5):571-607.
[13] Friedman S,Rubin PH,Bodian C,et al.Screening and surveillance colonoscopy in Crohn's disease[J].Gastroenterology,2001,120(4):820-826.
[14] Inoue T,Murano M,Abe Y,et al.Colonoscopic differences of erosive and/or small ulcerative lesions for diagnosis of colonic inflammatory diseases[J].J Gastroenterology Hepatic,2010,25(Supple 1):S149-S154.
[15] Kiesslich R,Fritsch J,Holtmann M,et al.Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis[J].Gastroenterology,2003,124(4):880-888.
[16] Bessissow T,Bisschops R.Advanced endoscopic imaging for dysplasia surveillance in ulcerative colitis[J].Expert Rev Gastroenterol Hepatol,2013,7(1):57-67.
[17] Kornbluth A,Sachar DB.Ulcerative colitis practice guideline in adults(update):American College of Gastroenterology,Practice Parameters Committee[J].Am J Gastroenterol,2004,99(7):1371-1385.
[18] Smith LA,Baraza W,Tiffin N,et al.Endoscopic resection of adenoma-like mass in chronic ulcerative colitis using a combined endoscopic mucosal resection and cap assisted submucosal dissection technique[J].Inflamm Bowel Dis,2008,14(10):1380-1386.
[19] Subramanian V,Logan RF.Chemoprevention of colorectal cancer in inflammatory bowel disease[J].Best Pract Res Clin Gastroenterol,2011,25(4-5):593-606.
[20] Velayos FS,Terdiman JP,Walsh JM.Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk:a systematic review and meta-analysis of observational studies[J].Am J Gastroenterol,2005,100(6):1345-1353.
[21] Terhaar Sive Droste JS,Tuynman JB,Van Dullemen HM,et al.Chemoprevention for colon cancer:new opportunities,fact or fiction?[J].Scand J Gastroenterol Suppl,2006,(243):158-164.
[22] Carroll C,Cooper K,Papaioannou D,et al.Supplemental calcium in the chemoprevention of colorectal cancer:a systematic review and meta-analysis[J].Clin Ther,2010,32(5):789-803.
[23] Wang JL,Lin YW,Chen HM,et al.Calcium prevents tumorigenesis in a mouse model of colorectal cancer[J].PLoS One,2011,6(8):e22566.
[24] Gisbert JP,Bermejo F,Pajares R,et al.Oral and intravenous iron treatment in inflammatory bowel disease:hematological response and quality of life improvement[J].Inflamm Bowel Dis,2009,15(10):1485-1491.
[25] Wiskin AE,Fleming BJ,Wootton SA,et al.Anaemia and iron deficiency in children with inflammatory bowel disease[J].J Crohns Colitis,2012,6(6):687-691.
[26] Beatty P,Ranganathan S,Finn OJ.Prevention of colitis-associated colon cancer using a vaccine to target abnormal expression of the MUC1 tumor antigen[J].Oncoimmunology,2012,1(3):263-270.

相似文献/References:

备注/Memo

备注/Memo:
基金项目: 国家自然科学基金课题资助项目(81070289)
更新日期/Last Update: 2013-08-05