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[1]常 林,陈红兵,朱 君,等.急性白血病患儿感染细小病毒B19的血常规和临床体征分析[J].医学研究与战创伤救治(原医学研究生学报),2013,15(05):470-473.[doi:10.3969/j.issn.1672-271X.2013.05.013]
　CHANG Lin,CHEN Hong-bing,ZHU Jun,et al.Hematological and clinical signs study for Parvovirus B19 infection in children with acute leukemia[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2013,15(05):470-473.[doi:10.3969/j.issn.1672-271X.2013.05.013]
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急性白血病患儿感染细小病毒B19的血常规和临床体征分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第15卷
期数:
2013年05期
页码:
470-473
栏目:
出版日期:
2013-10-20

文章信息/Info

Title:
Hematological and clinical signs study for Parvovirus B19 infection in children with acute leukemia
作者:
常 林; 陈红兵; 朱 君; 张雯雯
210009江苏南京，南京医科大学附属南京儿童医院检验科
Author(s):
CHANG Lin; CHEN Hong-bing; ZHU Jun; ZHANG Wen-wen
Clinical Laboratory,Nanjing Childrens Hospital Affiliated to Nanjing Medical University,Nanjing，Jiangsu 210009,China
关键词:
细小病毒B19; 急性白血病; 儿童; 血细胞减少
Keywords:
parvovirus B19;  acute leukemia;  children;  cytopenia
分类号:
R733.71
DOI:
10.3969/j.issn.1672-271X.2013.05.013
文献标志码:
A
摘要:
目的 通过检测新发现的急性白血病患儿和接受过化疗的急性白血病患儿体内细小病毒B19DNA及其血清中的特异性抗体，探讨细 小病毒B19感染对患儿血常规和临床体征的影响。方法 将2011年1月-2013年1月住院的95名急性白血病患儿分为两组。第一组：50名接受过化疗的急性白血病患儿；第二组：45名 新发现、未接受化疗的急性白血病患儿。两组采用PCR法检测细小病毒B19DNA,以ELISA法检测血清细小病毒B19-IgG和B19-IgM抗体。结果 ①第一组检测细小病毒B19病毒DNA阳性率 为32.0%，第二组为46.7%，对照组为零。②第一组当前感染的患儿有显著的血红蛋白和中性粒细胞水平下降及淋巴细胞增多；第二组当前感染的患儿有显著的中性粒细胞减少、血 小板减少以及淋巴细胞增多。③临床体征方面，两组当前感染患儿都有明显的肝脾、淋巴结肿大和发热。结论 不管有无接受过化疗，细小病毒B19感染都是急性白血病患儿血细胞 减少的重要原因。此外，细小病毒B19的感染与显著的肝脾、淋巴结肿大有一定的相关性。
Abstract:
Objective This study aimed to detect parvovirus B19 DNA together with its antibodies in the sera of children with recent acute leukemia and those with acute leukemia receiving chemotherapy to clarify the contribution of this infection to changes observed in hematological and clinical presentations in these population.Methods 95 cases of acute leukemia from January 2011 to January 2013 were analyzed by the method of retrospective study.Two groups were included:Group I comprised 50 children with acute leukemia receiving chemotherapy and Group II comprised 45 children with recently diagnosed acute leukemia.Serum parvovirus B19 IgG and IgM were investigated by enzyme-linked immunosorbant assay and the virus DNA was sought by polymerase chain reaction assay in 95 cases of acute leukemia and 40 cases of healthy children.Results ①Viral DNA was found in 32% of Group I patients and in 46.7% of Group II patients,the control group was not detected.②Hemoglobin levels were significantly reduced in patients with recent infection,accompanied by statistically significant lymphocytosis in Group I patients.Group II patients with recent infection had marked neutropenia with lymphocytosis and thrombocytopenia.③There was statistically significant lymphadenopathy and hepatosplenomegaly in patients with recent infection in both groups.Conclusion Parvovirus B19 infection is an important cause of cytopenia in children with acute leukemia both when recently diagnosed and receiving chemotherapy.This can affect the schedule of chemotherapy.Moreover,the presence of Parvovirus B19 is associated with marked lymphadenopathy and hepatosplenomegaly.

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相似文献/References:

[1]常林,陈红兵,朱纯亮,等.细小病毒B19和儿童急性白血病关系的探讨[J].医学研究与战创伤救治(原医学研究生学报),2016,18(02):171.[doi:10.3969/j.issn.1672-271X.2016.02.019]
　CHANG Lin,CHEN Hong-bing,ZHU Chun-liang,et al.Relationship between human parvovirus B19 and acute leukemia in child patients[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2016,18(05):171.[doi:10.3969/j.issn.1672-271X.2016.02.019]

备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-09-20