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[1]黄凤楼,刁孟元,钱海飞,等.降钙素原及内毒素对腹腔感染脓毒症患者预后的评估[J].医学研究与战创伤救治(原医学研究生学报),2014,16(02):147-149，191.[doi:10.3969/j.issn.1672-271X.2014.02.011]
　HUANG Feng-lou,DIAO Meng-yuan,QIAN Hai-fei,et al.Prognostic value of procalcitonin and endotoxin concentrations for intra-abdominal sepsis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(02):147-149，191.[doi:10.3969/j.issn.1672-271X.2014.02.011]
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降钙素原及内毒素对腹腔感染脓毒症患者预后的评估()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年02期
页码:
147-149，191
栏目:
出版日期:
2014-03-20

文章信息/Info

Title:
Prognostic value of procalcitonin and endotoxin concentrations for intra-abdominal sepsis
作者:
黄凤楼1; 刁孟元1; 钱海飞1; 秦保东2; 仲人前2
1.310002 浙江杭州，南京军区杭州疗养院海勤疗养区；2.200003 上海，上海长征医院
Author(s):
HUANG Feng-lou1; DIAO Meng-yuan1; QIAN Hai-fei1; QIN Bao-dong2; ZHONG Ren-qian2.
1.Naval Convalescent Department,Hangzhou Sanatorium of Nanjing Military District,Hangzhou,Zhejiang 310002,China；2.Shanghai Changzheng Hospital,Shanghai 200003,China
关键词:
降钙素原; 内毒素; 脓毒症; 腹腔感染; 预后
Keywords:
procalcitonin; endotoxin; sepsis; abdominal infections; prognosis
分类号:
R446.112.9
DOI:
10.3969/j.issn.1672-271X.2014.02.011
文献标志码:
A
摘要:
目的 探讨降钙素原(procalcitonin，PCT)及内毒素对于腹腔感染脓毒症患者预后的评估价值。方法 回顾性分析腹腔感染脓毒症86例的临床资料，根据预后(存活和死亡) 和病情严重程度(局部感染、脓毒症、严重脓毒症及脓毒症休克)分组，比较不同组别之间的PCT及内毒素水平，比较PCT和内毒素同急性生理和慢性健康状况评分Ⅱ(acute physiology and chronic health evaluation Ⅱ,APACHE Ⅱ)和脓毒症相关器官功能障碍评分(sepsis-related organ failure assessment score，SOFA)的相关性，并比较PCT、 内毒素和两个临床评分系统对于患者预后的评估价值。结果 根据不同评分及预后分组，各组之间PCT水平差异具有统计学意义，而内毒素水平差异无统计学意义。PCT与两个评分系 统具有很好的相关性，而内毒素与评分系统无显著相关。PCT、内毒素、APACHE Ⅱ和SOFA评分对于预后的受试者工作特征曲线(ROC曲线)下面积分别为85.7%、56.3%、86.7%和86.0% 。结论 PCT较内毒素能更好地评价腹腔感染脓毒症患者的预后。
Abstract:
Objective To evaluate the value of serum procalcitonin and endotoxin concentrations in prognosis of intra-abdominal sepsis.Methods A total of 86 patients with intra-abdominal sepsis were included into the study.We compared PCT and endotoxin concentrations according to classification of different outcomes (survivors and nonsurvivors) and intra-abdominal sepsis (local infections,sepsis,severe sepsis and septic shock).The correlation of PCT or endotoxin concentrations to APACHE Ⅱ or SOFA score were also analyzed,then see their function in judging the prognosis of sepsis.Results Nonsurvivors had a higher level of PCT than survivors.PCT concentrations was higher in patients with severe sepsis and septic shock than that with sepsis or local infections.PCT concentrations was associated with APACHE Ⅱ and SOFA score significantly,but not endotoxin.The area under ROC curve for predicting 28-days mortality of PCT,endotoxin,APACHE Ⅱ and SOFA score were 85.7%，56.3%，86.7% and 86.0%，respectively.Conclusion PCT had a higher prognostic value in intra-abdominal sepsis than endotoxin.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2014-03-20