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[1]冒晓蓓,刘小北,褚晓源,等.叉头框蛋白M1、环氧合酶2在结肠癌组织中的表达及相关性分析[J].医学研究与战创伤救治(原医学研究生学报),2014,16(03):225-228.[doi:10.3969/j.issn.1672-271X.2014.03.001]
　MAO Xiao-bei,LIU Xiao-bei,CHU Xiao-yuan,et al.Expression and correlation of FoxM1 and COX-2 in colorectal cancer[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(03):225-228.[doi:10.3969/j.issn.1672-271X.2014.03.001]
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叉头框蛋白M1、环氧合酶2在结肠癌组织中的表达及相关性分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年03期
页码:
225-228
栏目:
出版日期:
2014-05-20

文章信息/Info

Title:
Expression and correlation of FoxM1 and COX-2 in colorectal cancer
作者:
冒晓蓓; 刘小北; 褚晓源; 郁红菊
210002 江苏南京，第二军医大学南京临床医学院(南京军区南京总医院)肿瘤内科
Author(s):
MAO Xiao-bei; LIU Xiao-bei; CHU Xiao-yuan; YU Hong-ju.
Department of Internal Medicine-Oncology,Nanjing Clinical Medical College of Second Military Medical University,Nanjing General Hospital of Nanjing Military Region，Nanjing,Jiangsu 210002,China
关键词:
结肠癌; 叉头框蛋白M1; 环氧合酶2; 免疫组织化学
Keywords:
colorectal cancer;  FoxM1;  COX-2;  immunohistochemistry
分类号:
R735.35
DOI:
10.3969/j.issn.1672-271X.2014.03.001
文献标志码:
A
摘要:
目的 探讨叉头框蛋白M1(fork head box M1,FoxM1)和环氧合酶2(cyclooxygenase2,COX-2)在结肠癌(colorectal carcinoma,CRC)中的表达及两者的相关性。方法 采用免 疫组织化学法检测FoxM1和COX-2在95例CRC组织和40例正常结肠组织中的表达，分析FoxM1和COX-2与结肠癌临床病理参数间的关系及两者表达的相关性。结果 FoxM1和COX-2在CRC组 织中表达阳性率分别为 85.3%(81/95)和 87.4%(83/95)，显著高于正常结肠组织的 7.5%(3/40)和 12.5%(5/40)(P＜0.05)。FoxM1和COX-2的高表达与较多的淋巴结转移及较晚的临 床分期密切相关(P＜0.05)，且两者在CRC中的表达强度呈正相关(r=0.638，P＜0.05)。结论 FoxM1和COX-2的表达与CRC临床分期和淋巴结转移密切相关，提示其可能与CRC患者较差 的预后相关。
Abstract:
Objective To investigate the expression of fork head box M1(FoxM1) and cyclooxygenase-2 (COX-2) in colorectal cancer (CRC) and analyze the correlation between them.Methods Expressions of FoxM1and COX-2 were examined in 95 CRC tissues and 40 normal colon tissues by immunohistochemistry.Then the relationships among expression of FoxM1and COX-2 and clinicopathological parameters of CRC analyzed.Results Both the positivity rates of FoxM1 and COX-2 in CRC tissues were significantly higher than in normal colon tissues [FoxM1:85.3%(81/95 )vs 7.5%(3/40);COX-2:87.4%(83/95) vs 12.5%(5/40);P<0.05].Enhanced expressions of FoxM1 and COX-2 were still significantly correlated with the lymph node metastasis and advanced clinical stages in CRC (P<0.05).Meanwhile,a positive correlation was observed between FoxM1 and COX-2 experssions (r=0.638,P<0.05).Conclusion Over-expressions of FoxM1 and COX-2 are significantly correlated with the lymph node metastasis and advanced clinical stage of CRC in the development and advancement of CRC.

参考文献/References:

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备注/Memo

备注/Memo:
国家自然科学基金(81272394)
更新日期/Last Update: 2014-05-20