|本期目录/Table of Contents|

[1]黄 隽,徐 通,杨朋范,等.颞叶癫痫儿童脑海马组织内BDNF表达变化的意义[J].医学研究与战创伤救治(原医学研究生学报),2014,16(03):249-252.[doi:10.3969/j.issn.1672-271X.2014.03.008]
　HUANG Jun,XU Tong,YANG Peng-fan,et al.Expression of brain derived neurotrophic factor in brain tissue resected from children with temporal lobe epilepsy[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(03):249-252.[doi:10.3969/j.issn.1672-271X.2014.03.008]
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颞叶癫痫儿童脑海马组织内BDNF表达变化的意义()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年03期
页码:
249-252
栏目:
出版日期:
2014-05-20

文章信息/Info

Title:
Expression of brain derived neurotrophic factor in brain tissue resected from children with temporal lobe epilepsy
作者:
黄 隽1; 2; 徐 通2; 杨朋范3; 任榕娜1
1.350025 福建福州，南京军区福州总医院儿科；2.200003 上海，第二军医大学上海长征医院儿科；3.350025 福建福州，南京军区福州总医院神经外科癫痫中心
Author(s):
HUANG Jun1; 2; XU Tong2; YANG Peng-fan3; REN Rong-na1.
1.Pediatric Department,Fuzhou General Hospital of Nanjing Military Command,Fuzhou,Fujian 350025,China； 2.Pediatric Department,Shanghai Changzheng Hospital,Shanghai 200003,China；3.Neurosurgery Department,Fuzhou General Hospital of Nanjing Military Comma
关键词:
海马脑组织; 脑源性神经营养因子; 儿童; 颞叶癫痫
Keywords:
hippocampi tissues;  brain derived neurotrophic factor;  children;  temporal lobe epilepsy
分类号:
R742.1
DOI:
10.3969/j.issn.1672-271X.2014.03.008
文献标志码:
A
摘要:
目的 探讨脑源性神经营养因子(brain derived neurotrophic factor,BDNF)在颞叶癫痫(temporal lobe epilepsy,TLE)发病机制中的作用。方法 观察组为2012年3月- 2013年3月在某医院神经外科癫痫中心16例TLE患儿术中切除的海马脑组织，对照组为2011年9月-2013年3月某医院神经外科8例非癫痫手术患儿的海马脑组织。标本采用免疫组化 SABC法进行检测。免疫组化结果的判定以显微镜下观察，按每张切片的阳性细胞着色程度及数量，采用积分综合计量，并采用Ridit分析。结果 按照显微镜下观察评分对两组数据 进行分类，经Ridit分析可知两组分级差异有统计学意义(Hc=9.2472，P＜0.01)，故认为观察组海马脑组织中BDNF表达强于对照组中海马脑组织BDNF表达。结论 BDNF在颞叶癫痫患 儿的海马脑组织中表达增强，可能在颞叶癫痫的发病机制中起重要作用。
Abstract:
Objective To study the role of brain derived neurotrophic factor (BDNF) in the pathogenesis of temporal lobe epilepsy (TLE) in children.Methods Immunohistochemistry was used to test the expression of BDNF in the hippocampi tissues from 16 children with temporal lobe epilepsy from March 2012 to March 2013,and the results were compared with those from 8 children without epilepsy from September 2011 to March 2013.Results were analysised by the Ridit test.Results Under the microscope,Ridit test analysis showed:Hc=9.2472,P＜0.01.Expression of BDNF protein were significantly inscresed in the hippocampi tissues resected from patiens with TLE compared with that of contrasts.Conclusion The result indicate the expression of BDNF protein increased in hippocampus of brain tissue in patients with TLE.BDNF may play an important role in the development of temporal lobe epilepsy.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2014-05-20