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[1]李 萍,裴颖皓,宫剑滨.高同型半胱氨酸血症对原发性高血压患者左室重构的影响[J].医学研究与战创伤救治(原医学研究生学报),2014,16(03):253-256.[doi:10.3969/j.issn.1672-271X.2014.03.009]
　LI Ping,PEI Ying-hao,GONG Jian-bin..The influence of serum homocysteine on the remodeling of left ventricle in patients with essential hypertension[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(03):253-256.[doi:10.3969/j.issn.1672-271X.2014.03.009]
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高同型半胱氨酸血症对原发性高血压患者左室重构的影响()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年03期
页码:
253-256
栏目:
出版日期:
2014-05-20

文章信息/Info

Title:
The influence of serum homocysteine on the remodeling of left ventricle in patients with essential hypertension
作者:
李 萍; 裴颖皓; 宫剑滨
210002 江苏南京，南京军区南京总医院心内科
Author(s):
LI Ping; PEI Ying-hao; GONG Jian-bin.
Department of Cardiology,Nanjing General Hospital of Nanjing Military Command,Nanjing，Jiangsu 210002,China
关键词:
高血压病; 同型半胱氨酸; 左室重构
Keywords:
hypertension;  homocysteine;  left ventricular remodeling
分类号:
R544.11;R749.4
DOI:
10.3969/j.issn.1672-271X.2014.03.009
文献标志码:
A
摘要:
目的 评价血清同型半胱氨酸(Hcy)与高血压病患者左心室重构的相关性。方法 选取原发性高血压200例(其中合并高Hcy患者90例)，无高血压病史的高同型半胱氨酸血症 60例，以及健康对照志愿者40名。收集患者基本信息，血清Hcy水平，并完善血脂代谢及肝肾功能测定。采用美国超声心动图协会(ASE)推荐的标准方法测量相关心脏结构及功能指 标(LVDd，LVSd，IVS，LVPW，LVEF，LVFS，LVM，LVMI等)。结果 高血压合并高Hcy组LVM和LVMI水平明显升高(P＜0.05)，所有纳入对象血清Hcy水平与LVM(r=0.401，P=0.047)及 LVMI(r=0.422，P=0.041)呈正相关，剔除非高血压病患者后这种相关更加明显(rLVM=0.441，P=0.033；rLVMI=0.462，P=0.039)。结论 血清Hcy水平与左室质量(LVM)和左室质量指 数(LVMI)呈正相关，并且在高血压病患者中更加明显，是影响心血管结构的一个重要危险因素。
Abstract:
Objective To evaluate the correlation between the serum homocysteine (Hcy) and ventricular remodeling in patients with hypertension.Methods 200 patients with essential hypertension (including 90 hyperhomocysteinemia patients),60 hyperhomocysteinemia patients without hypertension and 40 healthy controls were selected in our study.The basic information,serum homocysteine and biochemical indicator were also collected.We measured the cardiac sturcture and function index (LVDd,LVSd,IVS and LVPW,LVEF,LVFS,LVM,LVMI etc) based on the American association of ultrasound cardiogram (ASE) recommended standard.Results The levels of LVM and LVMI increased in hypertension+HHcy group significantly (P<0.05).The levels of Hcy were positively correlated with LVM (r=0.401,P=0.047) and LVMI(r=0.422,P=0.041) in all objects enrolled the study,and more positive only in hypertension patients (rLVM=0.441，P=0.033； rLVMI=0.462，P=0.039).Conclusion The levels of Hcy were positively correlated with LVM and LVMI,and more obvious in hypertension patients.Hcy is an important risk factor for cardiovascular structures.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2014-05-20