|本期目录/Table of Contents|

[1]杨小骏,张海,金华.阻塞性睡眠呼吸暂停与非酒精性脂肪性肝病的关系研究[J].医学研究与战创伤救治(原医学研究生学报),2014,16(04):385-387,393.[doi:10.3969/j.issn.1672-271X.2014.04.016]
　YANG Xiao-jun,ZHANG Hai,JIN Hua..Research between obstructive sleep apnea and nonalcoholic fatty liver disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(04):385-387,393.[doi:10.3969/j.issn.1672-271X.2014.04.016]
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阻塞性睡眠呼吸暂停与非酒精性脂肪性肝病的关系研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年04期
页码:
385-387,393
栏目:
出版日期:
2014-07-31

文章信息/Info

Title:
Research between obstructive sleep apnea and nonalcoholic fatty liver disease
作者:
杨小骏; 张海; 金华
200050 上海，上海电力医院呼吸内科
Author(s):
YANG Xiao-jun; ZHANG Hai; JIN Hua.
Department of Respiration,Shanghai Electric Power Hospital,Shanghai 200050,China
关键词:
阻塞性睡眠呼吸暂停; 非酒精性脂肪性肝病; 慢性间歇性缺氧; 胰岛素抵抗
Keywords:
obstructive sleep apnea;  nonalcoholic fatty liver disease;  chronic intermittent hypoxia;  insulin resistance
分类号:
R766;R575.5
DOI:
10.3969/j.issn.1672-271X.2014.04.016
文献标志码:
A
摘要:
目的 探讨阻塞性睡眠呼吸暂停(OSA)与非酒精性脂肪性肝病(NAFLD)的关系。方法 141例进行多导睡眠监测的患者为研究对象，根据监测结果分为阻塞性睡眠呼吸暂停低通气综合征(OSAHS)组和非OSAHS组，均进行肝脏B超检查。比较两组间一般临床资料和实验室检查结果、呼吸暂停低通气指数(AHI)指数与NAFLD发病率关系以及最低血氧饱和度(LSaO2)与肝酶指标的相关性并分析原因。结果 诊断为OSAHS者83例，其他58例纳入非OSAHS组。OSAHS组的性别、年龄、血压、血脂、糖尿病、体质指数(BMI)和天冬氨酸氨基转移酶(AST)，与非OSAHS组比较差异无统计学意义(P＞0.05)，但丙氨酸氨基转移酶(ALT)、稳态模型胰岛素抵抗(HOMA-IR)指数和NAFLD发病率较非OSAHS组显著增高(P＜0.01)。AHI指数增加与NAFLD发病率相关。在OSAHS组中，LSaO2 与ALT呈负相关，而与AST无相关性。结论 OSA患者易于发生NAFLD，可能与胰岛素抵抗和夜间间歇性低氧有关。
Abstract:
Objective To investigate the relationship between obstructive sleep apnea and nonalcoholic fatty liver disease.Methods 141 patients who underwent polysomnography and liver ultrasonography were enrolled.The main clinical features were compared between patients with and without OSAHS.The relationship between AHI and incidence of NAFLD was evaluated,and Pearson’s correlation coefficient was calculated between serum aminotransferase values and LSaO2.Results 83 cases were diagnosed as OSAHS.There were no significant differences between two groups for gender distribution,age,hypertension,hyperlipidemia,diabetes mellitus,BMI or AST(P＞0.05).The incidence of NAFLD,ALT and HOMA-IR were significantly higher in OSAHS group compared with non-OSAHS group(P＜0.01).Pearson’s correlation coefficient demonstrated a significant correction between ALT and LSaO2 in OSAHS patients.Conclusion Patients with OSA are more prone to NAFLD,which may be associated with insulin resistance and nocturnal intermittent hypoxia.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2014-07-20