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[1]谭擎缨,王秀景,姚佳琦,等.男性2型糖尿病患者胰岛素抵抗与前列腺特异性抗原的相关性研究[J].医学研究与战创伤救治(原医学研究生学报),2014,16(05):473-475,519.[doi:10.3969/j.issn.1672-271X.2014.05.008]
　TAN Qing-ying,WANG Xiu-jing,YAO Jia-qi,et al.The association between insulin resistance and serum prostat specific antigen levels in male patients with type 2 diabetics[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(05):473-475,519.[doi:10.3969/j.issn.1672-271X.2014.05.008]
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男性2型糖尿病患者胰岛素抵抗与前列腺特异性抗原的相关性研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年05期
页码:
473-475,519
栏目:
出版日期:
2014-09-20

文章信息/Info

Title:
The association between insulin resistance and serum prostat specific antigen levels in male patients with type 2 diabetics
作者:
谭擎缨; 王秀景; 姚佳琦; 阮勇; 王静; 阮芸
310013浙江杭州，解放军117医院内分泌科
Author(s):
TAN Qing-ying; WANG Xiu-jing; YAO Jia-qi; RUAN Yong; WANG Jing; RUAN Yun．
Department of Endocrinology，117 Hospital of PLA，Hangzhou,Zhejiang 310013，China
关键词:
糖尿病; 2型; 胰岛素抵抗; 前列腺特异性抗原
Keywords:
diabetes msllitus; type 2;  insuline resistance;  prostat specific antigen
分类号:
R587.1
DOI:
10.3969/j.issn.1672-271X.2014.05.008
文献标志码:
A
摘要:
目的探讨在男性2型糖尿病患者中胰岛素抵抗与前列腺特异性抗原(prostate specific antigen，PSA)的相关性。方法 男性2型糖尿病183例，检测空腹血糖(FPG)、空腹胰 岛素(FINS)、糖化血红蛋白(HbA1C)、血脂系列(TC、TG、LDL、HDL)、游离前列腺特异性抗原(fPSA)和总前列腺特异性抗原(tPSA)浓度等相关临床指标，计算胰岛素抵抗指数(HOMA -IR)、体质指数(BMI)。根据HOMA-IR分为胰岛素抵抗组(IR≥2.8)和非胰岛素抵抗组(IR<2.8)；根据tPSA的中位数0.732 μg/L，将患者分为tPSA≥0.732 μg/L组和tPSA＜0.732 μ g/L组。结果 胰岛素抵抗组(69例)患者的BMI明显高于非胰岛素抵抗组(114例)(P<0.05)，tPSA明显低于非胰岛素抵抗组(P<0.05)。tPSA≥0.732 μg/L组(92例)的BMI、HOMA-IR均低 于tPSA＜0.732 μg/L组(91例)(均P<0.05)。tPSA与年龄、fPSA、LDL呈正相关(r分别为0.345、0.865、0.200；均P<0.05)，与IR、BMI呈负相关(r分别为-0.151、-0.155；均 P<0.05)。结论 胰岛素抵抗和肥胖是导致PSA下降的因素。
Abstract:
Objective To evaluate the relationship between insulin resistance and serum prostat specific antigen(PSA) levels in male patients with type 2 diabetics.Methods Totally 183 male patients with type 2 diabetics were included in this study.Biochemical analyses including fasting plasma glucose (FPG),serum fasting levels of insulin(FINS),HbA1C,lipid,free prostate specific antigen (fPSA) and total prostate specific antigen (tPSA) were performed． Insulin resistance index(HOMA-IR)and body mass index (BMI) were calculated．Based on HOMA-IR，patients were divided into insulin resistant group (IR>2.8) and non-insulin resistant group (IR<2.8).Based on median of tPSA，patients were divided into group of tPSA≥0.732 μg/L and group of tPSA<0.732 μg/L.Results BMI was more increased in insulin resistant group (69 cases) compared with non-insulin resistant group (114 cases) (P< 0.05)．tPSA was more increased in non- insulin resistant group compared with insulin resistant group(P<0.05)．BMI and HOMA-IR were more increased in group of tPSA<0.732 μg/L (91 cases) compared with group of tPSA≥0.732 μg/L (92 cases) (both P<0.05).tPSA was positively correlated with age,fPSA and LDL (r=0.345,0.865,0.200; all P<0.05),and negatively correlated with IR and BMI (r=-0.151,-0.155; both P<0.05).Conclusion Insulin resistance and obesity play roles in the PSA decreasing．

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备注/Memo

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更新日期/Last Update: 2014-09-20