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[1]于海容,孟浩,许柳柳,等.淮海地区慢性阻塞性肺病急性加重期合并下呼吸道感染患者的病原菌特点及药敏分析[J].医学研究与战创伤救治(原医学研究生学报),2014,16(05):499-501.[doi:10.3969/j.issn.1672-271X.2014.05.017]
　YU Hai-rong,MENG Hao,XU Liu-liu,et al.Sputum etiology and drug sensitivity tests for pations with lower respiratory infection on acute exacerbation chronic obstructive pulmonary disease in Huaihai region[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(05):499-501.[doi:10.3969/j.issn.1672-271X.2014.05.017]
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淮海地区慢性阻塞性肺病急性加重期合并下呼吸道感染患者的病原菌特点及药敏分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年05期
页码:
499-501
栏目:
出版日期:
2014-09-20

文章信息/Info

Title:
Sputum etiology and drug sensitivity tests for pations with lower respiratory infection on acute exacerbation chronic obstructive pulmonary disease in Huaihai region
作者:
于海容; 孟浩; 许柳柳; 李香彭
221004江苏徐州，解放军97医院呼吸科
Author(s):
YU Hai-rong; MENG Hao; XU Liu-liu; LI Xiang-peng.
Department of Respiratory，97 Hospital of PLA，Xuzhou，Jiangsu 221004,China
关键词:
慢性阻塞性肺疾病; 急性发作期; 病原菌; 药敏分析
Keywords:
chronic obstructive pulmonary disease; acute exacerbation;  etiology;  drug sensitivity test
分类号:
R563
DOI:
10.3969/j.issn.1672-271X.2014.05.017
文献标志码:
A
摘要:
目的了解淮海地区慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)急性加重期合并下呼吸道感染患者的病原菌特点及药敏分析，以指导临床合理用药 。方法 回顾性分析2010年1月-2013年12月住院的560例COPD急性加重(acute exacerbation chronic obstructive pulmonary disease,AECOPD)合并下呼吸道感染的痰液细菌培养结 果及药敏分析。结果 560例中分离到病原菌480株，G-杆菌296株，占61．67％，依次是铜绿假单胞菌、肺炎克雷伯杆菌、大肠埃希菌、洋葱假单胞菌、鲍曼不动杆菌。G+球菌106株 ，占22．08％，主要是金黄色葡萄球菌、溶血性葡萄球菌、化脓性链球菌。真菌78株，占16.25％，主要是白色念珠菌。药敏结果显示G-杆菌对碳青霉烯类、氨基糖甙类、头孢哌酮 舒巴坦钠较敏感；G+球菌对万古霉素、利奈唑胺、头孢哌酮舒巴坦钠敏感；真菌主要对氟康唑敏感。结论 AECOPD患者下呼吸道感染病原菌以G-杆菌为主，易合并真菌感染，根据药 敏结果合理应用抗生素是治疗的关键。
Abstract:
Objective To provide the rational application of antibiotics for the clinical treatment by analyzing acute exacerbation chronic obstructive pulmonary disease(AECOPD) patients with sputum culture and sensitivity Results in Huaihai region.Methods The clinical data of 560 cases with lower respiratory infection of AECOPD were obtained from January 2010 to December 2013 and analyzed retrospectively.Results 480 sputum pathogens of 560 cases were isolated.Gram-negative bacilli were found in 296 (61.67％),including concluding pseudomonas aeruginosa,klebsiella pneumoniae,escherichia coli,pseudomonas cepacia,acinetobacter baumannii and so on.Gram-positive aureus were detected in 106 (22.08%),composed with staphylococcus aureus,haemolyticus staphylococcus and streptococcus pyogenes．Fungus pathogens were occurred in 78 (16.25%),most of which were candida albicans.The main Gram-negative bacilli were sensitive to carbapenems,aminoglycoside,cefoperazone sodium and sulbactam sodium.The main Gram-positive aureus were sensitive to vancomycin,linezolid,cefoperazone sodium and sulbactam sodium.Fungus was sensitive to fluconazole.Conclusion Gram-negative bacilli are the main pathogenic bacterium and fungal infection is followed usually.The key of treatment is to use antibiotics reasonably according to the Results of drug sensitive experiment.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2014-09-20