|本期目录/Table of Contents|

[1]李爱梅,孙一文,贾 鹏,等.肝细胞源性肝癌PET-CT成像标准摄取值与葡萄糖转运蛋白1的关系[J].医学研究与战创伤救治(原医学研究生学报),2015,17(06):572-574590.[doi:10.3969/j.issn.1672-271X.2015.06.004]
　LI Ai-mei,SUN Yi-wen,JIA Peng,et al.Relationship of standardized uptake value of PET-CT imaging and glucose transporter 1 in hepatocellular carcinoma[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(06):572-574590.[doi:10.3969/j.issn.1672-271X.2015.06.004]
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肝细胞源性肝癌PET-CT成像标准摄取值与葡萄糖转运蛋白1的关系()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年06期
页码:
572-574590
栏目:
出版日期:
2015-12-15

文章信息/Info

Title:
Relationship of standardized uptake value of PET-CT imaging and glucose transporter 1 in hepatocellular carcinoma
作者:
李爱梅; 孙一文; 贾 鹏; 郭万华
210008 江苏南京，南京大学医学院附属南京鼓楼医院核医学科
Author(s):
LI Ai-mei;  SUN Yi-wen;  JIA Peng;  GUO Wan-hua.
Nuclear Medicine Departmentof Nanjing Drum Tower Hospital，Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China
关键词:
肝细胞源性肝癌; 中分化; 正电子发射断层显像; 葡萄糖转运蛋白1
Keywords:
hepatocellular carcinoma;  moderately differentiate;  PET-CT;  glucose transporter 1
分类号:
R735.7
DOI:
10.3969/j.issn.1672-271X.2015.06.004
文献标志码:
A
摘要:
目的 探讨中分化肝细胞源性肝癌正电子发射断层显像（PET-CT）成像中标准摄取值（standardized uptake value，SUVmax）与葡萄糖转运蛋白1（glucose transporter 1,GLUT1）的关系。方法 搜集2008年1月-2015年5月本院30例中分化肝细胞源性肝癌PET-CT成像资料和相关临床资料，通过SUVmax进行分组，对组织切片进行GLUT1检测，利用统计分析软件SPSS 19.0进行统计学分析。结果 依据SUVmax<7和SUVmax≥7将患者分为中低摄取和高摄取两组，两组SUVmax差异具有统计学意义（P<0.05）；组织切片GLUT1检测结果提示中低摄取组和高摄取组GLUT1的表达差异具有统计学意义（P<0.05），且SUVmax与GLUT1的表达量存在相关性（r=0.581，P<0.05）。结论 GLUT1是影响中分化肝细胞源性肝癌PET-CT成像中SUVmax的重要因素。
Abstract:
Objective To investigate the relationship between glucose transporter protein 1 and standardized uptake value of PET-CT imaging in moderately differentiated hepatocellular cancer. Methods Collect 30 cases of moderately differentiated HCC PET-CT data and corresponding clinical data from 2008.1 to 2015.5 in our hospital. They were grouped through the standard uptake value (SUVmax ). GLUT1 was detected in tissue slice and SPSS 19.0 was used for statistical analysis. Results Patients were divided into low-mild intake group (SUVmax<7) and high uptake group(SUVmax≥7). Two groups of SUVmax exist significant difference (P<0.05); GLUT1 of paraffin section by immunity fluorescence detection in low consuming group and high intake group also exist significant difference (P<0.05). Spearman correlation analysis showed that SUVmax was correlated with the expression of GLUT1 (r=0.581, P<0.05). Conclusion Glucose transporter protein 1 is an important factor for HCC PET-CT imaging.

参考文献/References:

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备注/Memo

备注/Memo:
国家自然基金面上项目（81171363）
更新日期/Last Update: 2015-11-20