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[1]罗贤文,胡宇霞,吴建伟.软组织肿瘤异常摄取骨显像剂99mTc-MDP的临床意义[J].医学研究与战创伤救治(原医学研究生学报),2015,17(06):591-593.[doi:10.3969/j.issn.1672-271X.2015.06.009]
　LUO Xian-wen,HU Yu-xia,WU Jian-wei..Clinical significance of abnormal soft tissue tumor uptake of bone trace 99mTc-MDP[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(06):591-593.[doi:10.3969/j.issn.1672-271X.2015.06.009]
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软组织肿瘤异常摄取骨显像剂99mTc-MDP的临床意义()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年06期
页码:
591-593
栏目:
出版日期:
2015-12-15

文章信息/Info

Title:
Clinical significance of abnormal soft tissue tumor uptake of bone trace 99mTc-MDP
作者:
罗贤文; 胡宇霞; 吴建伟
210002 江苏南京，解放军81医院影像科
Author(s):
LUO Xian-wen;  HU Yu-xia;  WU Jian-wei.
Department of Radiology, 81 Hospital of PLA, Nanjing, Jiangsu 210002, China
关键词:
放射性核素显像; 99m锝-亚甲基二膦酸盐; 软组织肿瘤; 组织分布
Keywords:
radionuclide imaging;  99mTc-MDP;  soft tissue tumor;  tissue distribution
分类号:
R817.4；R738.6
DOI:
10.3969/j.issn.1672-271X.2015.06.009
文献标志码:
A
摘要:
目的 探讨软组织肿瘤异常摄取骨显像剂99m锝-亚甲基二膦酸盐(99mTc-MDP)的临床意义。方法 自2009年5月-2014年12月，6350例患者行SPECT骨显像，共发现29例32处软组织肿瘤异常摄取99mTc-MDP，其中13例经病理确诊，另16例经CT（n=8）、MR（n=5）和PET/CT（n=3）予以证实。测量软组织肿瘤大小，对其摄取显像剂程度进行分级，并分析摄取程度在原发和转移病灶之间的差别。结果 32处异常摄取99mTc-MDP的肿瘤长径中位数为5.9（3.0～20.0）cm；其中原发性恶性肿瘤15处，转移性肿瘤17处，原发性肿瘤摄取Ⅱ级为14处，1处为Ⅲ级摄取；转移性恶性肿瘤异常摄取Ⅱ级为11处，Ⅲ级异常摄取者5处，Ⅳ级异常摄取1处。原发性肿瘤与继发性肿瘤在低、高级别异常摄取骨显像剂方面差异无统计学意义（P＞0.05）。结论 部分体积较大的原发性和转移性肿瘤摄取骨显像剂99mTc-MDP的摄取水平多为Ⅱ～Ⅲ级；全身骨显像时发现软组织异常骨显像剂摄取时，应高度怀疑恶性肿瘤的可能。
Abstract:
Objective To evaluate the clinical significance of abnormal soft tissue tumor uptake of bone tracer(99mTc-methylene diphosphonic acid, 99mTc-MDP). Methods From May 2009 to Dec 2014, radionuclide imaging(wholebody bone scan) was performed in 6350 patients with malignancy in our department，and 32 soft tissue tumor uptake of 99mTc-MDP was found in 29 patients. The final diagnosis was obtained from pathology (n=13), typical imaging findings (CT=8, MR=5 and PET/CT=3, respectively). The maximal diameter of lesions were measured, the uptake level was graded and their difference between primary and metastatic lesions were analyzed. Results The median diameter of 32 soft tissue lesions diagnosed as uptake 99mTc-MDP was 5.9 (3.0-20.0 cm). There were 15 primary tumor (gradeⅡ=14, grade Ⅲ=1) and 17 metastatic tumors(gradeⅡ=11, grade Ⅲ=5, gradeⅣ=1 ). There was no statistical differences in low (gradeⅡ) and high (grade Ⅲ and Ⅳ) level uptake between primary and metastatic tumor (P＞0.05). Conclusion Soft tissue tumor, especially some large lesions, could uptake bone tracer 99mTc-MDP and the uptake level were gradeⅡ-Ⅲ mostly. Malignancy should be highly suspected when the soft tissues uptake 99mTc-MDP in skeleton imaging.

参考文献/References:

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更新日期/Last Update: 2015-11-20