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[1]吉蘅山,孙传金,朱 虹,等.18F-NaF PET/CT与99Tcm-MDP骨显像诊断骨转移瘤价值的对比研究[J].医学研究与战创伤救治(原医学研究生学报),2015,17(06):642-644661.[doi:10.3969/j.issn.1672-271X.2015.06.025]
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18F-NaF PET/CT与99Tcm-MDP骨显像诊断骨转移瘤价值的对比研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年06期
页码:
642-644661
栏目:
出版日期:
2015-12-15

文章信息/Info

Title:
-
作者:
吉蘅山; 孙传金; 朱 虹; 王新刚; 汤元翔; 褚丹丹
210002 江苏南京，南京军区南京总医院核医学科
Author(s):
-
关键词:
骨转移瘤; 正电子发射计算机断层扫描; 亚甲基二膦酸盐; 骨显像; 氟化钠
Keywords:
-
分类号:
R817
DOI:
10.3969/j.issn.1672-271X.2015.06.025
文献标志码:
B
摘要:
目的 对比分析了氟化钠（18F-Fluoride，18F-NaF） PET/CT骨显像与99Tcm-亚甲基二膦酸盐（99Tcm-methylene diphosphonate，99Tcm-MDP）SPECT骨显像对诊断骨转移瘤的价值，探讨18F-NaF PET/CT显像诊断恶性肿瘤骨转移的临床价值。方法 对24例恶性肿瘤患者在1周内行18F-NaF PET/CT、99Tcm-MDP SPECT显像，其中肺癌18例，乳腺癌2例，前列腺癌2例，贲门癌、软骨肉瘤各1例，患者中男19例，女5例。结果 24例患者中，最终诊断10例患者出现骨转移，18F-NaF PET/CT显像发现全部骨转移患者，另有1例患者不能定性诊断，在随访中证明为良性病例。99Tcm-MDP诊断骨转移7例，另有3例不能定性诊断，在随访中证实为转移病例。按病变水平分析时，18F-NaF PET/CT显像与99Tcm-MDP SPECT显像共发现转移病灶92个，良性病灶28个，其中18F-NaF PET/CT显像发现全部转移病灶，良性病灶26个，另有2个病灶不能定性，在随访中证实为良性病变，敏感性100%，特异性92.8%，准确性98.3%。99Tcm-MDP SPECT显像发现骨转移病灶86个，良性病灶18个，敏感性93.5%，特异性69.2%，准确性88.1%。结论 18F-NaF PET/CT显像的敏感性、特异性、准确性均高于99Tcm-MDP SPECT显像。
Abstract:
-

参考文献/References:

[1] Kruger S,Buck AK,Mottaghy FM,et al. Detection of bone metastases in patients with lung cancer:99mTc-MDP planar bone scintigraphy,18F-fluoride PET or18F-FDG PET/CT[J]. Eur J Nucl Med Mol Imaging,2009,11(36):1807-1812. [2] 饶良俊,王晓燕,陈志丰,等.对比分析99mTc-MDP SPECT与18F-NaF PET/CT术前诊断肺癌骨转移的价值[J].中国医学影像技术,2012,28(12):2233-2238. [3] Petersen H,Ogren M,Hoilund-Carlsen PF. Fluoride-positron emission tomography/computed tomography for differential diagnosis in suspected bone metastasis[J]. Ugeskr Laeger,2010,172(20):1538-1539. [4] Aparici CM,Win AZ. Use of Na18F positron emission tomography/ computed tomography in the detection of bone metastasis from papillary renal cell carcinoma[J]. World J Nucl Med,2014,13(2):135-137. [5] Tateishi U,Morita S,Taguri M,et al. A meta-analysis of18F-Fluoride positron emission tomography for assessment of metastatic bone tumor[J]. Ann Nucl Med,2010, 24(7):523-531. [6] 程竟仪,张英剑,王新村,等.Na18F用于肿瘤骨转移病灶显像及其诊断价值[J].上海医学影像,2012,21(3):173-178. [7] Lim R,Fahey FH,Drubach LA, et al. Early experience with 18fluorine sodium fluoride bone PET in young patients with back pain[J].J Pediatr Orthop,2007,27(3):277-282. [8] Blake GM, Park-Holohan S J,Cook GJ,et al.Quantitative studies of bone with the use of 18F-fluoride and 99Tcm-methylene diphosphonate[J]. SeminNucl Med,2001, 31(11):28-49. [9] Ullmark G, Sorensen J, Nilsson O,et al.Analysis of bone formation on porous and calcium phosphate-coated acetabular cups:a randomized clinical 18fluoride study[J].Hip Int,2012,22(2):172-178. [10] 王俊起,高 硕.PET评价骨转移瘤[J].国际放射医学核医学杂志,2006,30(2):87-90. [11] 李彦生,王俊起,刘 磊,等. 18F-NaF的合成及其在肺癌骨转移中的临床应用[J].中华核医学杂志,2006,2(26):18-20. [12] Yen RF,Chen CY,Cheng MF,et al. The diagnostic and prognostic effectiveness of 18F sodium fluoride PET-CT in detecting bone metastases for hepatocellular carcinoma patients[J]. Nucl Med Commun,2010,31(7):637-645. [13] Doot RK,Muzi M,Peterson LM,et al.Kinetic analysis of 18F fluoride PET images of breast cancer bone metastases[J]. J Nucl Med,2010,51(4):521-527. [14] Freesmeyer M,Stecker FF,Schierz JH,et al. First experience with early dynamic 18F-NaF-PET/CT in patients with chronic osteomyelitis[J].Ann Nucl Med,2014,28(4):314-321. [15] Kawaguchi M, Tateishi U, Shizukuishi K,et al.18F-fluoride uptake in bone metastasis: morphologic and metabolic analysis on integrated PET/CT[J]. Ann Nucl Med,2010,24(4):241-247. [16] 吴建伟,赵 颖,艾书跃,等.PET/CT在探查胃肠道黏液腺癌和印戒细胞癌术后转移中的作用[J].东南国防医药,2012,14(2):123-125. [17] 李彩云,龚谋春,潘建虎,等.卵巢癌二次探查手术前PET-CT检查的作用及临床意义[J].东南国防医药,2013,15(2):141-143. [18] Bortot DC,Amorim BJ,Oki GC,et al. 18F-fluoride PET/CT is highly effective for excluding bone metastases even in patients with equivocal bone scintigraphy[J]. Eur J Nucl Med Mol Imaging,2012,39(11):1730-1736. [19] Bhargava P,Hanif M,Nash C. Whole-body 18F sodium fluoride PET-CT in a patient with renal cell carcinoma[J].Clin Nucl Med,2008,33(12):894-895. [20] Even-Sapir E, Metser U, Mishani E, et al. The detection of bone metastases in patients with high-risk prostate cancer:99Tcm-MDP planar bone scintigraphy,single-and multi-field-of-view SPECT,18F-fluoride PET,and18F-fluoride PET/CT[J]. J Nucl Med, 2006, 47(2):287-297.

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备注/Memo

备注/Memo:
南京军区南京总医院院内课题（2014054）
更新日期/Last Update: 2015-11-20