|本期目录/Table of Contents|

[1]蔡 慧,丁一波,马立业,等.炎症信号网络及其关键分子事件在胃癌进化发育中的作用[J].医学研究与战创伤救治(原医学研究生学报),2016,18(03):290-293.[doi:10.3969/j.issn.1672-271X.2016.03.021]
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炎症信号网络及其关键分子事件在胃癌进化发育中的作用()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第18卷
期数:
2016年03期
页码:
290-293
栏目:
综述
出版日期:
2016-06-30

文章信息/Info

Title:
-
作者:
蔡 慧1; 丁一波1; 马立业2; 杜 琰3; 曹广文1
1. 200433上海,第二军医大学流行病学教研室;2. 200433上海,第二军医大学附属长海医院普外科;3. 200011上海,复旦大学附属妇产科医院
Author(s):
-
关键词:
胃癌; 炎症; 关键分子; 进化
Keywords:
-
分类号:
R735.2；R735.3
DOI:
10.3969/j.issn.1672-271X.2016.03.021
文献标志码:
A
摘要:
胃癌在全世界范围的发病率居男性第四位和女性第五位，且大部分新病例发生在东南亚国家，为重要公共卫生问题。尽管外科手术为主的综合治疗是目前胃癌治疗有效手段，但不同国家术后5年生存率差异性很大。胃癌的发生、发展及转移是一个复杂的生物学过程，受到遗传、环境、饮食等多种因素的影响，体现了“变异-选择-适应”的进化过程。胃癌术后复发和转移是患者死亡的主要原因，其分子机制尚不明确，但这一过程可能与胃癌发生的机制相似，通常由宿主免疫系统失衡，炎症相关信号网络在癌旁组织中激活引起。胃癌的炎症相关恶性转化大多是由病原体感染驱动的，是多种细胞、基因、非编码RNA等共同参与的生物学过程。以免疫调控的炎症网络为切入点，运用系统生物学方法，结合流行病学队列研究，从胃癌预后相关高通量基因标志谱中挖掘、整合和评价关键分子事件，开发有效性更高的预测预后标志群，同时结合临床及病理学信息进行预测，对于加快胃癌的个体化治疗、改善病人预后具有重要意义。
Abstract:
-

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备注/Memo

备注/Memo:
国家973计划资助项目（2015CB554003）
更新日期/Last Update: 2016-05-20