|本期目录/Table of Contents|

[1]柏书博综述,王敬晗,陈贵敏审校.抑癌基因LKB1与肿瘤关系的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2016,18(04):408-410,414.[doi:10.3969/j.issn.1672-271X.2016.04.022]
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抑癌基因LKB1与肿瘤关系的研究进展()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第18卷
期数:
2016年04期
页码:
408-410,414
栏目:
综述
出版日期:
2016-08-20

文章信息/Info

Title:
-
作者:
柏书博1综述 王敬晗2 陈贵敏1审校
1. 200052上海,解放军85医院口腔科; 2. 100048北京,解放军海军总医院肝胆外科
Author(s):
-
关键词:
抑癌基因肝激酶B1肿瘤 细胞生长和代谢
Keywords:
-
分类号:
R730.2;Q754
DOI:
10.3969/j.issn.1672-271X.2016.04.022
文献标志码:
A
摘要:
肝激酶B1(LKB1)是一种具有普遍作用的抑癌基因,编码一种丝氨酸/苏氨酸激酶,LKB1基因的胚系突变是黑色素斑-胃肠多发性息肉综合征的主要致病因素。现有研究表明,LKB1对细胞代谢、 细胞周期和细胞极性等的调控是其抑制肿瘤发生和发展的重要方面。LKB1的失活性表达以低频率事件广泛存在于全身多种类型恶性肿瘤中,如肺癌、胃癌和乳腺癌等;其功能异常还与腺癌的发生密切相 关。本文就目前已知的LKB1的抑癌机制作以综述。
Abstract:
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参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2016-07-20