|本期目录/Table of Contents|

[1]赵爱琴,谢玮莉,王焱.体外冲击波对膝骨关节炎患者血清及关节液中Chemerin含量的影响[J].医学研究与战创伤救治(原医学研究生学报),2016,18(05):498-500.[doi:10.3969/j.issn.1672-271X.2016.05.015]
　ZHAO Ai-qin,XIE Wei-li,WANG Yan.Effect of extracorporeal shock wave on the level of Chemerin in serum and synovia in patients with knee osteoarthritis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2016,18(05):498-500.[doi:10.3969/j.issn.1672-271X.2016.05.015]
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体外冲击波对膝骨关节炎患者血清及关节液中Chemerin含量的影响()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第18卷
期数:
2016年05期
页码:
498-500
栏目:
出版日期:
2016-09-20

文章信息/Info

Title:
Effect of extracorporeal shock wave on the level of Chemerin in serum and synovia in patients with knee osteoarthritis
作者:
赵爱琴; 谢玮莉; 王焱
100091北京，解放军309医院旃坛寺门诊部
Author(s):
ZHAO Ai-qin;  XIE Wei-li;  WANG Yan
Outpatient Department of Zhantanshi,309 Hospital of PLA, Beijing 100091,China
关键词:
体外冲击波; 膝骨关节炎; 趋化素
Keywords:
extracorporeal shock wave;  knee osteoarthritis;  Chemerin
分类号:
R681.3
DOI:
10.3969/j.issn.1672-271X.2016.05.015
文献标志码:
A
摘要:
目的 探讨体外冲击波（extracorporeal shock wave，ESW）对膝骨关节炎（knee osteoarthritis，KOA）的疗效及对患者血清及关节液趋化素(Chemerin)的影响。方法 60例KOA患者随机分为ESW组（n=30）和对照组（n=30），ESW组以体外冲击波治疗，对照组以常规治疗。在干预前和8周后，采用活动时疼痛视觉模拟评分（VAS）、膝关节炎病人疼痛指数(Lequesne index)评分和美国西部Ontario与McMaster大学骨关节炎指数（western Ontario and McMaster osteoarthritis index,WOMAC）评分进行评定，以及血清及关节液中Chemerin水平的变化。结果 治疗后，ESW组VAS、Lequesne指数评分和WOMAC骨关节炎指数评分均明显好于对照组（P＜0.05）。治疗后患者血清和关节液中Chemerin含量均比治疗前显著下降（P＜0.05或0.01）；治疗后ESW组血清和关节液中Chemerin含量显著低于对照组（均P＜0.05）。结论 膝关节液和血清中Chemerin含量反映了关节炎症的严重程度,ESW治疗有效的降低了血清和关节液中Chemerin含量，ESW对KOA患者治疗有效，Chemerin可作为OA早期诊断及判断严重程度的参考指标。
Abstract:
Objective To investigate the therapeutic effect of extracorporeal shock wave (ESW) on patients with knee osteoarthritis (KOA), and observe the effect of ESW on the level of Chemerin in serum and synovia. Methods 60 patients were randomly assigned to ESW group (n=30) and control group (n=30). The ESW goup was received ESW treatment on unilateral knee, while there was routine treatment in the control group. They were evaluated with Visual Analog Scale (VAS) on movement, Lequesne index and Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index before intervention and 8 weeks after the intervention. The level of Chemerin in serum and synovia were measured before intervention and 8 weeks after the intervention. Results The scores of VAS, Lequesne index and WOMAC index improved in ESW group than that in the control group after intervention (P<0.05). The level of Chemerin in serum and synovia in two groups after intervention were significantly lower than those before intervention (P<0.05 or 0.01); The level of Chemerin in serum and synovia in ESW group after intervention was significantly lower than those in control group (all P<0.05). Conclusion The level of Chemerin in serum and synovia reflects the degree of synovitis. ESW therapy can effectively reduce the level of Chemerin in serum and synovia. ESW is effective on patients with KOA. Chemerin level can be used as a reference biomarker of diagnosis and severity of OA.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2016-12-09