|本期目录/Table of Contents|

[1]汪勇,赵武伟,汪朝晖,等.小剂量奥氮平与奋乃静治疗肝移植术后精神障碍的对照研究[J].医学研究与战创伤救治(原医学研究生学报),2016,18(06):572-574.[doi:10.3969/j.issn.1672-271X.2016.06.004]
　WANG Yong,ZHAO Wu-wei,WANG Zhao-hui,et al.Treatment of patients with mental disorders after liver transplantation by using olanzapine or perphenazine: a control study[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2016,18(06):572-574.[doi:10.3969/j.issn.1672-271X.2016.06.004]
点击复制

小剂量奥氮平与奋乃静治疗肝移植术后精神障碍的对照研究()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第18卷
期数:
2016年06期
页码:
572-574
栏目:
出版日期:
2016-11-20

文章信息/Info

Title:
Treatment of patients with mental disorders after liver transplantation by using olanzapine or perphenazine: a control study
作者:
汪勇1; 赵武伟2; 汪朝晖3; 相芳4; 雷文婧2; 李增才5; 王轩5
210002江苏南京，解放军81医院,1.院部，2.神经内科， 3.肝病中心，4.药剂科，5.肝移植中心
Author(s):
WANG Yong1;  ZHAO Wu-wei2; WANG Zhao-hui3;  XIANG Fang4; LEI Wen-jing2;  LI Zeng-cai5;  WANG Xuan5.
1.Office of the Director, 2.Department of Neurology, 3.Liver Disease Center, 4.Department Of Pharmacy, 5.Liver Transplantation Center,81 Hospital of PLA, Nanjing, Jiangsu 210002, China
关键词:
奥氮平; 肝移植; 精神障碍; 治疗效果
Keywords:
olanzapine;  liver transplantation;  mental disorder;  therapeutic effect
分类号:
R617
DOI:
10.3969/j.issn.1672-271X.2016.06.004
文献标志码:
A
摘要:
目的 观察小剂量奥氮平治疗肝移植术后精神障碍的疗效及安全性。方法 选取肝移植术后2周内出现精神障碍患者78例，随机分为观察组（39例）和对照组(39例)。两组均在手术后给予相同基 础药物治疗。观察组给予奥氮平片2.5 mg，每晚1次口服，每2 d增加2.5 mg，总剂量不超过10 mg。对照组给予奋乃静片1 mg，每晚1次口服。每2 d增加1 mg，总剂量不超过4 mg。分别在治疗前、治疗2 周后，进行简明精神病（科）量表(BPRS)、不良反应量表（TESS）评分及体质量测定。结果 观察组治疗前BPRS评分为(72.11±8.16)，治疗2周后为（52.30±6.14），差异有统计学意义（P<0.05）。观 察组治疗前BPRS 评分为 (71.26±8.01)，治疗2周后为（65.50±7.22），差异无统计学意义（P>0.05）。治疗后，两组BPRS评分比较，差异有统计学意义（P<0.01）。两组均不良反应轻微，并可自行 缓解。结论 小剂量奥氮平治疗肝移植术后精神障碍疗效明确，安全可靠，有一定的临床应用价值。
Abstract:
Objective To observe the efficacy and safety of low dose olanzapine on patients with mental disorders after liver transplantation. Methods 78 cases of transplantation was divided into BPRS treatment group (n=39) and control group (n=39). Olanzapine were given each night with the dose of 2.5mg and increased 2.5mg every other day till up to 10mg in treatment group. In control Group, perphenazine was given each night with the dose of 1mg and increased 1mg every other day till up to 4mg. BPRS and TESS were used to assess the efficacy and adverse events before and after two weeks of the treatment respectively. Results BPRS after treatment for two weeks decreased compared with before (72.11 ±8.16 vs. 52.30±6.14,P<0.05), but no significant difference was observed in control group (71.26±8.01 vs. 65.50±7.22, P>0.05). BPRS also decreased in treatment group compared with control group two weeks after LT (P<0.05).Adverse events in two groups were mild and can remiss simultaneously. Conclusion Low dose of olanzapine is an effective and safe drug in controlling mental disorder after liver transplantatation and is valuable in clinical application.

参考文献/References:

[1]潘军平,朱新华,施晓雷,等.大鼠自体原位肝移植术后不同胆道热缺血时间对胆管及其周围血管丛的影响[J].医学研究生学报,2013,26(7):709-713.
[2]李君.肝移植手术患者焦虑状态及精神心理的干预措施[J].中国医科大学学报,2014,43（6）:568-570.
[3]马倩红.肝移植术后精神异常相关因素分析及护理干预[J].中国实用护理杂志,2014,30（增刊）:154-155.
[4]白玉春.肝移植术后精神异常的相关因素分析及护理进展[J].护士进修杂志,2016,31（2）:127-129.
[5]阎同军，王彦彦，陈方斌，等.奥氮平与奎硫平对阿尔茨海默病吞咽功能影响[J].中华行为医学与脑科学杂志,2015,24（1）:46-49.
[6]李婉妮，阎菊娥，李玺，等.小剂量奥氮平对住院患者焦虑失眠缓解作用的临床观察[J].陕西医学杂志,2014,43(12):1663-1664.
[7]姜涛,魏琴,侯琴琴,等.奥氮平诱导性肥胖大鼠糖代谢紊乱及认知功能损伤研究[J].医学研究生学报,2015,28(3):264-267.
[8]徐银，韩永升，李凯，等.奥氮平治疗肝豆状核变性精神障碍近期疗效观察[J].安徽医学,2011,32(4):410-412.
[9]黄小梅，黄丹，胡丽芳，等.肝移植患者术后精神障碍的相关因素分析及护理对策[J].中国医药指南,2013,11(21):695-697.
[10]曹海梅，龙烁.肝移植术后神经精神并发症的原因及临床应对[J].中国现代医学杂志,2010,20(12):1875-1876.
[11]阳文新，于乐成，周斌，等.肝移植术后中枢神经系统并发证的特点及危险因素分析[J].肝脏,2011,16(2):95-99.
[12]吴彩云，吴爱琴，李华杰，等.奥氮平治疗精神病性障碍36例初步观察[J].上海精神医学，2000,12（1）:44-45.
[13]朱羞阳，佟洋，李驰荣，等.选择性5-羟色胺再摄取抑制剂与奥氮平联合治疗难治性抑郁症的临床疗效[J].东南国防医药，2013,15（2）:125-127.
[14]李小燕，邱静，王锐，等.奥氮平、喹硫平对阿尔茨海默病患者睡眠呼吸影响 [J].东南国防医药，2015,17（1）:8-11.

相似文献/References:

[1]朱羞阳,佟洋,李驰荣,等.选择性5-羟色胺再摄取抑制剂与奥氮平联合治疗难治性抑郁症的临床疗效[J].医学研究与战创伤救治(原医学研究生学报),2013,15(02):125.
　Air force Hangzhou Aviation Medicine Assessment and Training Center,Hangzhou,Zhejiang 00,et al.ZHU Xiu-yang,TONG Yang,LI Chi-rong[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2013,15(06):125.
[2]周 斌,何咸兵,段家芳,等.中老年肝移植围手术期的临床分析[J].医学研究与战创伤救治(原医学研究生学报),2012,14(06):507.
　ZHOU Bin,HE Xian-bing,DUAN Jia-fang,et al.Clinical analysis of liver transplantation perioperatively in the aged patients over sixty years of age[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(06):507.
[3]阳文新,何咸兵,王跃华,等.肝移植术后弥漫性脑病的特点及危险因素分析[J].医学研究与战创伤救治(原医学研究生学报),2012,14(05):396.
　YANG Wen-xin,HE Xian-bing,WANG Yue-hua,et al.Features of diffuse encephalopathy after liver transplantation and its risk factors[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(06):396.
[4]江 艺,杨 芳,陈少华,等.补救性肝移植治疗小肝癌疗效分析[J].医学研究与战创伤救治(原医学研究生学报),2011,13(02):119.
　JIANG Yi,YANG Fang,CHEN Shao-hua,et al.Salvage liver transplantation for recurrence after resection of small hepatocellular carcinoma[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(06):119.
[5]蒋玉娣,许凤燕,鲍 磊.肝移植术中的体温护理[J].医学研究与战创伤救治(原医学研究生学报),2011,13(02):164.
[6]李爱梅,郭万华,贾鹏,等.肝癌肝移植术后18F-FDG PET/CT显像特点和预后判断[J].医学研究与战创伤救治(原医学研究生学报),2010,12(05):393.
　LI Ai-mei,GUO Wan-hua,JIA Peng,et al.Imaging of 18F-FDG PET/CT and its value in prediction of prognosis in patients with hepatocellular carcinoma after transplantation[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(06):393.
[7]赵建生,佟波涛,段加方,等.肝移植术中心跳骤停4例临床初探[J].医学研究与战创伤救治(原医学研究生学报),2009,11(04):326.
　ZHAO Jian-sheng,TONG Bo-tao,DUAN Jia-fang,et al.Clinical analysis of cardiac arrest in 4 cases during liver transplantation[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2009,11(06):326.
[8]蒋玉娣,许凤燕,鲍磊.肝移植术中患者皮肤护理的体会[J].医学研究与战创伤救治(原医学研究生学报),2009,11(05):451.
[9]林小燕,邱 静,王 锐,等.奥氮平、喹硫平对阿尔茨海默病患者睡眠呼吸的影响[J].医学研究与战创伤救治(原医学研究生学报),2015,17(01):8.[doi:10.3969/j.issn.1672-271X.2015.01.003]
　LIN Xiao-yan,QIU Jing,WANG Rui,et al.Effects of olanzapine and quetiapine on sleep-breathing in patients with Alzheimer disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(06):8.[doi:10.3969/j.issn.1672-271X.2015.01.003]
[10]王国平,李霞,何朗,等.奥氮平联合盐酸吗啡缓释片治疗癌性疼痛的疗效和安全性分析[J].医学研究与战创伤救治(原医学研究生学报),2020,22(6):622.[doi:10.3969/j.issn.1672-271X.2020.06.014]
　WANG Guo-ping,LI Xia,HE Lang,et al.Effect and safety analysis of olanzapine combined with morphine hydrochloride sustained release tablets in the treatment of cancerous pain[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2020,22(06):622.[doi:10.3969/j.issn.1672-271X.2020.06.014]

备注/Memo

备注/Memo:
南京军区“十一五”重点项目资助（09Z011）
更新日期/Last Update: 2016-11-20