|本期目录/Table of Contents|

[1]侯君,窦建卫,李静,等.血痛定巴布剂抗炎镇痛作用的药效学研究[J].医学研究与战创伤救治(原医学研究生学报),2017,19(01):8-12.[doi:10.3969/j.issn.1672-271X.2017.01.003]
 HOU Jun,DOU Jian-wei,LI Jing,et al.Anti-inflammatory and analgesic effect of Xuetongding cataplasm[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2017,19(01):8-12.[doi:10.3969/j.issn.1672-271X.2017.01.003]
点击复制

血痛定巴布剂抗炎镇痛作用的药效学研究()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第19卷
期数:
2017年01期
页码:
8-12
栏目:
出版日期:
2017-01-20

文章信息/Info

Title:
Anti-inflammatory and analgesic effect of Xuetongding cataplasm
作者:
侯君1窦建卫2李静1
1.610083成都,成都军区总医院药剂科;2.710061西安,西安交通大学药学院;3.610021成都,解放军第452医院眼科;4.610075成都,成都中医药大学附属医院内分泌科;5.250031济南,济南军区总医院心外科;6. 400037重庆,第三军医大学新桥医院临床药理基地
Author(s):
HOU Jun1DOU Jian-wei2LI Jing1 LIU Ai-qin3YOU Feng-ming4ZHENG De-zhi5LI Dan-dan6ZHOU Long-fu1HU Yong-he1
(1.Department of Pharmacy,General Hospital of Chengdu Military Region,Chengdu 610083,Sichuan, China;2.School of Pharmacy,Xi′an Jiaotong University,Xi′an 710061,Shaanxi, China;3. Department of Ophthalmology,the 452th Hospital of PLA,Chengdu 610021,Sichuan, China;
关键词:
血痛定巴布剂抗炎镇痛
Keywords:
Xuetongding cataplasm Anti-inflammatory Analgesic effect
分类号:
R285
DOI:
10.3969/j.issn.1672-271X.2017.01.003
文献标志码:
A
摘要:
目的 评价血痛定巴布剂的抗炎镇痛作用。方法 采用炎症、疼痛动物模型,观察血痛定巴布剂的药效作用。结果 血痛定巴布剂可显著降低小鼠腹腔毛细血管通透性,可显著降低二甲苯所致耳廓肿胀和小鼠肉芽肿,可显著抑制角叉菜胶所致足趾肿胀;可显著减少醋酸致小鼠扭体次数,对小鼠热刺激所致痛阈值的变化不明显。结论 血痛定巴布剂具有明显的抗炎作用,无镇痛作用。
Abstract:
Objective To evaluate the anti-inflammatory and analgesic effects of Xuetongding cataplasm.Methods Animal models of inflammation and ache were adopted, and pharmacodynamic actions of Xuetongding cataplasm were observed.Results Xuetongding cataplasm lowered the capillaries permeability distinctly and inhibited xylol-induced mouse ear inflammation and cotton ball-induced mouse granuloma. Xuetongding cataplasm could conspicuously restrain rat foot metatarsus tumid treated by carrageenan, and decreased the twist-reaction stimulated by acetic acid. Thermal stimulation did not change pain threshold significantly.Conclusion Xuetongding cataplasm has obvious anti-inflammatory effects, and no analgesic effects

参考文献/References:

[1]李亨,许学猛,陈能,等.自热式痹痛巴布剂的药效学研究[J]. 中药新药与临床药理,2014,25(4):442-445.
[2]李驰荣,张尊祥,蔡晓红,等.散瘀止痛巴布膏对大鼠试验性炎症和疼痛药效学研究[J]. 东南国防医药,2008,10(5):349-351.
[3]卫生部药政局.中药新药临床前研究指导原则汇编[M].北京:人民卫生出版社.
[4]陈奇.中药药理研究方法学[M].北京:人民卫生出版社.
[5]徐叔云,卞如濂,陈修.药理实验方法学[M].3版.北京:人民卫生出版社.
[6]余玖霞,陆兔林,毛春芹,等.中药硇砂不同品种抗炎作用及急性毒性实验研究[J]. 南京中医药大学学报,2012,28(1):77-79.
[7]张乐之,孟德胜,温宝书,等.祛瘀宁痛贴治疗急性软组织损伤的实验研究[J]. 中国中医骨伤科杂志,2004,12(1):35-37.
[8]周国林,姚全胜,潘玉英.一种动物软组织损伤的实验方法[J]. 中国药理学通报,1991,7(5):396-398.
[9]邵先舫,刘志军,熊辉,等. 中医药外治急性软组织损伤实验研究现况及进展[J]. 中医药导报,2011,17(2):98-100.
[10]袁建迪,朱少兵,沈彦,等. 中医外治急性软组织损伤的临床研究进展[J]. 中医外治杂志,2008,17(1):41-43.
[11]贾伟,高文远,王涛,等.中药巴布剂的研究现状[J]. 中国中药杂志,2003,28(1):7-10.
[12]万东桂.痛块消巴布剂治疗癌性疼痛的临床研究[D].北京:北京中医药大学,2003:57-58

相似文献/References:

[1]陈 岚,陈 翠,高 毅,等.巴戟天提取物对大鼠类风湿性关节炎作用的观察[J].医学研究与战创伤救治(原医学研究生学报),2011,13(04):305.
 CHEN Lan,CHEN Cui,GAO Yi,et al.Observation of the effect of Morinda offcinalis How on rat rheumatoid arthritis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(01):305.
[2]李驰荣,张尊祥,蔡晓红,等.散瘀止痛巴布膏对大鼠试验性炎症和 疼痛药效学研究[J].医学研究与战创伤救治(原医学研究生学报),2008,10(05):349.
 LI Chi-rong,ZHANG Zun-xiang,CAI Xiao-hong,et al.The pharmacodynamic study of the Ba Bu dissipation blood clot and pain-relieving cream on experimental inflammation symptom and ache of rat[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2008,10(01):349.

备注/Memo

备注/Memo:
基金项目:国家科技重大专项课题(2014ZX09J14107-03B)
更新日期/Last Update: 2017-01-20