|本期目录/Table of Contents|

[1]熊燕.α-硫辛酸联合依帕司他治疗糖尿病周围神经病变临床疗效的Meta分析[J].医学研究与战创伤救治(原医学研究生学报),2017,19(01):58-61.[doi:10.3969/j.issn.1672-271X.2017.01.016]
　XIONG Yan.A meta-analysis of clinical efficacy of a-lipoic acid joint epalrestat treat diabetic peripheral neuropathy[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2017,19(01):58-61.[doi:10.3969/j.issn.1672-271X.2017.01.016]
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α-硫辛酸联合依帕司他治疗糖尿病周围神经病变临床疗效的Meta分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第19卷
期数:
2017年01期
页码:
58-61
栏目:
出版日期:
2017-01-20

文章信息/Info

Title:
A meta-analysis of clinical efficacy of a-lipoic acid joint epalrestat treat diabetic peripheral neuropathy
作者:
熊燕
作者单位：404000重庆，重庆三峡中心医院中医科
Author(s):
XIONG Yan
(Department of Traditional Chinese Medicine, Chongqing Three Groges Central Hospital, Chongqing 404000, China)
关键词:
硫辛酸; 依帕司他; 糖尿病周围神经病变
Keywords:
A-lipoic acid;  Epalrestat;  Diabetic peripheral neuropathy
分类号:
R587.2
DOI:
10.3969/j.issn.1672-271X.2017.01.016
文献标志码:
A
摘要:
目的 客观评价α-硫辛酸联合依帕司他治疗糖尿病周围神经病变(DPN)的疗效。方法 通过检索CNKI、VIP、万方数据库，收集近十年来以α-硫辛酸联合依帕司他为治疗组的随机对照试验。对纳入文献进行质量评价，运用Cochrane协作网提供的RevMan5.3.5软件对数据进行分析，评价α-硫辛酸联合依帕司他治疗糖尿病周围神经病变的疗效。结果 共纳入7篇文献，包含570例病例，其中治疗组261例，对照组309例。Meta分析发现，治疗组显效率明显高于对照组，MD=2.26，95%CI[1.56，3.25]，差异有统计学意义(P<0.000 1)。此外，治疗组改善感觉正中神经、腓总神经、运动正中神经、腓总神经传导速度优于对照组。结论 α-硫辛酸联合依帕司他能够缓解DPN患者症状，改善感觉及运动神经的传导速度，效果明显优于单用α-硫辛酸或依帕司他。
Abstract:
Objective The effect of a-lipoic acid joint epalrestat in treating diabetic peripheral neuropathy was evaluated Objective ly.Methods By retrieving CNKI, VIP, Wanfang Database, the randomized controlled trial with a-lipoic acid joint Epalrestat treatment was collected over the past decade. The quality of included studies were evaluated and the data was analyzed using the Cochrane Collaboration software provides RevMan5.3.5, then assessed the effect of them.Results Seven randomized controlled trial(570 cases) were included. Efficiency of improving the symptoms of DPN in combination group was significantly higher (MD=2.26, 95%CI [1.56, 3.25], P<0.000 1). In improving nerve conduction velocity, the effect of combination group was better than the control group.Conclusion The meta-analysis on this group shows that a-lipoic acid joint epalrestat can improve the clinical symptoms in patients with diabetic peripheral neuropathy, and the effects are better than control group in improving nerve conduction velocity

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更新日期/Last Update: 2017-01-20