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[1]申红,姚露,刘建红,等.参附注射液联合胸部γ-刀放疗的临床疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2017,19(03):243-247.[doi:10.3969/j.issn.1672-271X.2017.03.005]
　SHEN Hong,YAO Lu,LIU Jian-hong,et al.Clinical effect of shenfu injection combined with γ-knife in chest radiotherapy[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2017,19(03):243-247.[doi:10.3969/j.issn.1672-271X.2017.03.005]
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参附注射液联合胸部γ-刀放疗的临床疗效观察()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第19卷
期数:
2017年03期
页码:
243-247
栏目:
出版日期:
2017-05-20

文章信息/Info

Title:
Clinical effect of shenfu injection combined with γ-knife in chest radiotherapy
作者:
申红1; 姚露1;  刘建红2;  宋琳琳1; 刘传祥1; 杨爱珍1; 阳文新1
作者单位：1.210002南京，解放军第81医院急诊科；2. 100820北京，火箭军总医院礼士路门诊部
Author(s):
SHEN Hong1; YAO Lu1;  LIU Jian-hong2; SONG Lin-lin1;  LIU Chuan-xiang1;  YANG Ai-zhen1;  YANG Wen-xin1
(1.Emergency Department, the 81th Hospital of PLA, Nanjing 210002, Jiangsu, China；2.Outpatient Department, the Rocket General Hospital of PLA, Beijing 100820, China)
关键词:
参附注射液; γ-刀; 胸部放疗; 临床疗效
Keywords:
Shenfu injection;  γ-knife;  Chest radiotherapy;  Clinical effect
分类号:
R730.55
DOI:
10.3969/j.issn.1672-271X.2017.03.005
文献标志码:
A
摘要:
目的 观察参附注射液联合胸部γ-刀治疗恶性肿瘤的临床疗效。方法 将解放军第81医院收治的40例有胸部病灶的恶性肿瘤患者随机分成2组，治疗组为参附注射液联合γ-刀放疗，对照组为单纯γ-刀放疗，比较2组临床疗效及毒副作用。结果 治疗组疾病控制率为65%，对照组为50%，2组疾病控制率差异无统计学意义（P＞0.05）；2组总生存期差异无统计学意义（P＞0.05）；治疗组生活质量总改善率明显高于对照组（65% vs 40%,P<0.05）；治疗后，治疗组体液免疫指标、细胞免疫指标、恶病质细胞因子水平较对照组均有明显改善（P<0.05）；治疗组高级别放射性肺损伤发生率为20%，明显低于对照组的60%（P<0.05）。结论 参附注射液能减轻因γ-刀放疗引起的不良反应，治疗组患者生活质量及免疫功能有显著性改善，具有临床获益。
Abstract:
Objective To observe the clinical effect of shenfu injection combined with γ-knife in the treatment of chest malignant tumor.Methods 40 malignant tumor patients with chest lesions were randomly divived into 2 groups. The treatment group was given shenfu injection combined with γ-knife radiotherapy, and the control group was given γ-knife radiotherapy. To compare clinical curative effect and side effect of the two groupsResults The DCR had no significant difference in the two groups (P>0.05) with the treatment group 65% and the control group 50%. The OS of the two groups was not significantly different(P>0.05). After the therapy, the improvement of the quality of life in the treatment group was significantly higher than that in the control group (P<0.05). The treatment group was 65% and the control group was 40%. After the therapy, the humor immunity, cellular immunity, cachexia cytokine of the treatment group were improved significantly than those of the control group (P< 0.05). The high-level RILI incidence in the treatment was significantly lower than that in the control group (P<0.05). The treatment group was 20% and the control group was 60%.Conclusion The shenfu injection can reduce the side effects caused by γ-knife radiotherapy. The quality of life and the immune function in the treatment group are significant improved. The shenfu injection has a certain clinical benefit.

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更新日期/Last Update: 2017-05-20