|本期目录/Table of Contents|

[1]朱颖春,刘景瑜,宋天然,等.内膜刺激对于薄型子宫内膜患者冷冻胚胎移植结局的影响[J].医学研究与战创伤救治(原医学研究生学报),2017,19(05):477-480.[doi:10.3969/j.issn.1672-271X.2017.05.007]
 ZHU Ying-chun,LIU Jing-yu,SONG Tian-ran,et al.The outcomes of frozen embryo transfer in patients with thin endometrium with local stimulation[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2017,19(05):477-480.[doi:10.3969/j.issn.1672-271X.2017.05.007]
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内膜刺激对于薄型子宫内膜患者冷冻胚胎移植结局的影响()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第19卷
期数:
2017年05期
页码:
477-480
栏目:
出版日期:
2017-09-29

文章信息/Info

Title:
The outcomes of frozen embryo transfer in patients with thin endometrium with local stimulation
作者:
朱颖春刘景瑜宋天然王玢贺方方孙海翔
作者单位:210008南京,南京大学医学院附属鼓楼医院生殖医学中心
Author(s):
ZHU Ying-chunLIU Jing-yuSONG Tian-ranWANG BinHE Fang-fang SUN Hai-xiang
(Reproductive Medical Center,Drum Tower Hospital Affiliated to Nanjing University School of Medicine,Nanjing 210008,Jiangsu,China)
关键词:
内膜刺激薄型子宫内膜妊娠结局子宫内膜容受性
Keywords:
Endometrial stimulation Thin endometrium Outcomes of embryo transfer Uterine receptivity
分类号:
R711.6
DOI:
10.3969/j.issn.1672-271X.2017.05.007
文献标志码:
A
摘要:
目的 评估内膜刺激对于薄型子宫内膜患者的冷冻胚胎移植结局的影响。方法 回顾性分析157周期移植优质冷冻胚胎的薄型子宫内膜患者临床资料,将上述周期分为内膜刺激组和非内膜刺激组。内膜刺激组60个周期的患者于胚胎移植周期前一周期对内膜进行刺激;非内膜刺激组97个周期的患者于胚胎移植周期前一周期未行内膜刺激。比较2组临床妊娠率、着床率、异位妊娠率以及早期流产率。结果 内膜刺激组和非内膜刺激组比较, 临床妊娠率(61.67% vs 52.58%)、着床率(44.34% vs 41.88%)有所提高,异位妊娠率(2.70% vs 3.92%)、早期流产率(8.11% vs 17.65%)有所降低,但以上指标的差异均不具统计学意义(P>0.05)。结论 内膜刺激对于薄型子宫内膜患者冷冻胚胎移植的妊娠率、着床率有提高的趋势,异位妊娠率、早期流产率有降低的趋势。
Abstract:
Objective The paper evaluates the impacts of endometrial stimulation to thin endometrium in patients on frozen embryo transfer outcomes.Methods Retrospective analysis of 157 cycles included in this study in which patients with thin endometrium were transferred with high quality division frozen embryos. The cycles were divided into endometrial stimulation group (experimental group) and the non-stimulation group (control group).Patients of Endometrial stimulation group (60 embryo transfer cycles) received Endometrial stimulation 1 week before transplantation. Patients of non-stimulation group (97 embryo transfer cycles) were treated without Endometrial stimulation. The clinical pregnancy rate, implantation rate, ectopic pregnancy rate and early abortion rate were compared between the two groups.Results Clinical pregnancy rate (61.67% vs 52.58%) and implantation rate (44.34% vs 41.88%) increased in endometrial stimulation group than that in non-stimulation group, and ectopic pregnancy rate (2.70% vs 3.92%) and early abortion rate (8.11% vs 17.65%) decreased in endometrial stimulation group than that in non-stimulation group. However, the differences between the two groups were not statistically significant.Conclusion Endometrial stimulation for patients with thin endometrium had a tendency to improve pregnancy rate and implantation rate of frozen embryo transfer. Ectopic pregnancy rate and early abortion rate had a tendency to reduce. But based on the sample size and other factors, the difference between the two groups was not statistically significant. We need to expand the sample size, and refine the details for further discussion.

参考文献/References:

[1]Bassil S. Changes in endometrial thickness, width, length and pattern in predicting pregnancy outcome during ovarian stimulation in in vitro fertilization[J]. Ultrasound Obst Gyn, 2001, 18(3): 258-263.
[2]Momeni M,Rahbar MH,Kovanci E.A meta-analysis of therelationship between endometrial thickness and outcome of in vitro fertilization cycles[J]. J Hum Reprod Sci,2011,4(3):130-137.
[3]Senturk LM, Erel CT. Thin endometrium in assisted reproductive technology[J]. Curr Opin in Obstet Gyn, 2008, 20(3): 221-228.
[4]Barash A, Dekel N, Fieldust S, et al. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization[J]. Fertil Steril, 2003, 79(6): 1317-1322.
[5]Karimzadeh MA,Ayazi Rozbahani M,Tabibnejad N. Endometrial local injury improves the pregnancy rate among recurrent implantation failure patients undergoing in vitro fertilisation/intra cytoplasmic sperm injection: a randomised clinical trial[J]. Aust NZ J Obst Gyn, 2009, 49(6): 677-680.
[6]Basir GS, So WWK, Ng EHY, et al. Evaluation of cycle-to-cycle variation of endometrial responsiveness using transvaginal sonography in women undergoing assisted reproduction[J]. Ultrasound Obst Gyn, 2002, 19(5): 484-489.
[7]陈骞,孙海翔,胡娅莉,等. 子宫内膜厚度对体外受精-胚胎移植治疗结局的影响[J]. 生殖与避孕,2008,28(12):730-733.
[8]钟华,唐至立. 超声评价卵巢反应性和子宫内膜容受性与IVF-ET妊娠结局关系探讨[J]. 中外医学研究,2017,15(9):52-53.
[9]李蓉,钟凯,卢丽华,等. 胚胎移植周期机械刺激子宫内膜提高临床妊娠率[J]. 生殖医学杂志,2004,13(6):342-345.
[10]Karpovich N, Chobotova K, Carver J, et al. Expression and function of interleukin-11 and its receptor α in the human endometrium[J]. Mol Hum Reprod, 2003, 9(2): 75-80.
[11]Smith SK, Charnock-Jones DS, Sharkey AM. The role of leukaemia inhibitory factor and interleukin-6 in human reproduction[J]. Hum Reprod, 1998, 13(suppl 3): 237-243.
[12]Almog B, Shalom-Paz E, Dufort D, et al. Promoting implantation by local injury to the endometrium[J]. Fertil Steril, 2010, 94(6): 2026-2029.
[13]Nastri CO, Ferriani RA, Raine-Fenning NJ, et al. OP11.08: Effect of local injury to the endometrium on endometrial vascularization in women undergoing assisted reproduction: a randomized controlled trial[J]. Ultrasound Obst Gyn, 2012, 40(S1):89.
[14]王安然,吴洪波,李柳铭,等. 子宫内膜浅表机械刺激对IVF-ET者子宫内膜血流动力学及妊娠结局的影响[J]. 广西医科大学学报,2013,30(2):240-242.
[15]Kalma Y, Granot I, Gnainsky Y, et al. Endometrial biopsy-induced gene modulation: first evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium[J]. Fertil Steril, 2009, 91(4): 1042-1049.
[16]李先莲. 改良式内膜刺激对体外受精-胚胎移植的影响[J]. 中国药物与临床,2014,15(6):844-845.
[17]Nastri CO,Lensen SF,Gibreel A,et al.Endometrial injury in women undergoing assisted reproductive techniques[J]. Cochrane Database Syst Rev, 2015, doi: 10.1002/14651858.CD009517.pub3.
[18]Mor G,Cardenas I,Abrahams V.Inflammation and pregnancy: the role of the immune system at the implantation site[J]. Ann NY Acad Sci, 2011, 1221(1): 80-87.
[19]Granot I,Gnainsky Y.Endometrial inflammation and effect on implantation improvement and pregnancy outcome[J]. Reprod (Camb Engl), 2012, 144(6): 661-668.
[20]Huang SY, Wang CJ, Soong YK, et al. Site-specific endometrial injury improves implantation and pregnancy in patients with repeated implantation failures[J]. Reprod Biol Endocrinol, 2011, 9: 140. doi: 10.1186/1477-7827-9-140.
[21]胡玥玥,黄晓卉,江胜芳,等.子宫内膜浅搔刮对胚胎移植周期结局的影响[J]. 中国优生与遗传杂志,2012,20(10):121-122,60.
[22]林洪波. 子宫内膜微刺激修整装置:中国,CN 201768020 U[P].2011-03-23.
[23]于晓莉,赵丽文,张烨敏,等. 黄体中期血清孕酮测定和子宫内膜活检在不孕症诊断中的意义[J]. 东南国防医药,2010,12(5):401-403.
[24]高明霞,陈思同,李丽斐,等. 人粒细胞集落刺激因子(G-CSF)宫腔灌注改善子宫内膜容受性的临床研究[J]. 生殖与避孕,2014,34(7):527-533.
[25]孙琴,李鸿儒,邵一丹,等. 他莫昔芬用于薄型子宫内膜患者冻融胚胎移植疗效观察的随机对照临床研究[J]. 医学研究生学报,2017,30(1):52-56.
[26]Ding L, Li X, Sun H, et al. Transplantation of bone marrow mesenchymal stem cells on collagen scaffolds for the functional regeneration of injured rat uterus[J]. Biomaterials, 2014, 35(18): 4888-4900.
[27]Song T, Zhao X, Sun H, et al. Regeneration of uterine horns in rats using collagen scaffolds loaded with human embryonic stem cell-derived endometrium-like cells[J]. Tissue Eng Part A, 2014, 21(1-2): 353-361.

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更新日期/Last Update: 2017-09-20