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[1]王敏,陈世伟,许春,等.包皮环切术前后夫妻共患高危型人乳头瘤病毒感染率变化[J].医学研究与战创伤救治(原医学研究生学报),2018,20(02):134-137.[doi:10.3969/j.issn.1672-271X.2018.02.006]
　WANG Min,CHEN Shi-wei,XU Chun,et al.The effect of circumcision on the high-risk human papillomavirus changes amongconcordance infection couples[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2018,20(02):134-137.[doi:10.3969/j.issn.1672-271X.2018.02.006]
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包皮环切术前后夫妻共患高危型人乳头瘤病毒感染率变化()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第20卷
期数:
2018年02期
页码:
134-137
栏目:
出版日期:
2018-03-20

文章信息/Info

Title:
The effect of circumcision on the high-risk human papillomavirus changes amongconcordance infection couples
作者:
王敏; 陈世伟; 许春; 吴勇智; 姜黎明; 赵色玲
作者单位：361003厦门，解放军第一七四医院（厦门大学附属成功医院）泌尿外科（王敏、陈世伟、许春、吴勇智、姜黎明、赵色玲）
Author(s):
WANG Min;  CHEN Shi-wei;  XU Chun;  WU Yong-zhi;  JIANG Li-ming;  ZHAO Se-ling
（Department of Urology,the 174th Hospital of PLA/Xiamen University Affiliated Chenggong Hospital, Xiamen 361003,Fujian,China）
关键词:
人乳头瘤病毒; 包皮环切术; 病毒清除; 基因检测
Keywords:
human papillomavirus;  male circumcision;  virus clearance;  gene detection
分类号:
R697.1
DOI:
10.3969/j.issn.1672-271X.2018.02.006
文献标志码:
A
摘要:
目的 探讨分析包皮环切术（MC）前后夫妻共患高危型人乳头瘤病毒（HPV）感染率变化。方法 选择解放军第一七四医院140对经包皮或宫颈组织脱落细胞高危型HPV检测双方均为HPV阳性的夫妻，且男方均有包皮过长，进行前瞻性、单中心、随机对照试验。随机分为2组：手术组70对夫妻，男性均行包皮环切术；对照组70对夫妻，男性未行包皮环切术。留取治疗前和治疗后1年男性包皮覆盖区（尿道口、阴茎头、冠状沟和包皮内板）、非包皮覆盖区（阴茎干、阴囊和肛周）、女性宫颈分泌物，采用PCR法检测高危型HPV的表达。结果 治疗前2组患者无论男性女性高危型HPV感染率之间的差异无统计学意义（P>0.05）。术后1年复查，手术组男性包皮覆盖区的高危型HPV感染率明显低于对照组（44.3% vs 78.6%，P<0.01）；但是非包皮覆盖区在2组之间比较差异无统计学意义（P>0.05）。对于女性患者，手术组HPV转阴率明显高于对照组（51.4% vs 20.0%，P<0.01），手术前后单一亚型感染率明显低于对照组（30.0% vs 44.3%，P<0.01），多亚型HPV感染率明显低于对照组（18.6% vs 35.7%，P<0.01）。结论 MC可以降低包皮过长男性包皮覆盖区以及配偶高危型HPV感染率的发生。
Abstract:
Objective To explore the effect of circumcision on preventing high-risk human papilloma virus (HPV) in concordance infection couples.Methods The subjects were 140 married couples diagnosed and treated in the 174th hospital of PLA. All the couples were confirmed as high-risk HPV concordance infection and husbands were suffering from redundant prepuce. 70 couples with circumcised men were set as surgery group, and 70 couples with uncircumcised were set as control group. The couples’ infection was detected again after 1 year.Results The rate of high-risk HPV infection in two groups were compared and the difference was not statistically significant (P＞0.05). After 1 year, HPV high-risk group male circumcision coverage area of surgical infection rate was significantly lower than the control group (44.3% vs 78.6%, P＜0.01); For the famale patients, the HPV negative rate in surgery group was lower than that in control group (51.4% vs 20.0%, P＜0.01), Comparison between preoperative and postoperative data showed that the operation of single subtype infection rate was significantly lower than the control group (30.0% vs 44.3%, P＜0.01), the operation of subtype HPV infection rate was significantly lower than the control group (18.6% vs 35.7%, P＜0.01). Conclusion Male circ-umcision is an effective measure to reduce the prevalence and incidence of high-risk HPV in men and their wives.

参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2018-03-20