|本期目录/Table of Contents|

[1]王心综述,陈铖审校.沉默信息调节因子1对肾间质保护作用的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2018,20(02):177-180.[doi:10.3969/j.issn.1672-271X.2018.02.016]
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沉默信息调节因子1对肾间质保护作用的研究进展()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第20卷
期数:
2018年02期
页码:
177-180
栏目:
综述
出版日期:
2018-03-20

文章信息/Info

Title:
-
作者:
王心综述陈铖审校
作者单位:430060武汉,武汉大学人民医院(湖北省人民医院)肾内科(王心、陈铖)
Author(s):
-
关键词:
沉默信息调节因子1肾小管间质急性肾损伤慢性肾损伤
Keywords:
-
分类号:
R334
DOI:
10.3969/j.issn.1672-271X.2018.02.016
文献标志码:
A
摘要:
肾间质病变涉及到细胞的凋亡、坏死、纤维化。研究显示,间质病变与肾功能的关系可能较肾小球硬化与肾功能异常更为密切。沉默信息调节因子1(SIRT1)是一种依赖于烟酰胺腺嘌呤二核苷酸(NAD+)的组蛋白去乙酰化酶,是sirtuins家族的重要成员,通过调节细胞凋亡、代谢、自噬等过程在疾病中发挥保护作用。随着研究深入,其在肾间质的病理生理过程的作用逐渐受到关注,文章就SIRT1在肾小管细胞坏死、凋亡,间质纤维化中的保护作用进行综述。
Abstract:
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参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2018-03-20