|本期目录/Table of Contents|

[1]邸婷婷综述,卞涛审校.DNA甲基化在COPD发病机制中的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2018,20(06):614-617.[doi:10.3969/j.issn.1672-271X.2018.06.012]
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DNA甲基化在COPD发病机制中的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第20卷
期数:
2018年06期
页码:
614-617
栏目:
综述
出版日期:
2018-11-20

文章信息/Info

Title:
-
作者:
邸婷婷综述; 卞涛审校
作者单位：214023无锡，南京医科大学附属无锡市人民医院呼吸内科(邸婷婷、卞涛)
Author(s):
-
关键词:
DNA甲基化; 表观遗传学; 慢性阻塞性肺疾病
Keywords:
-
分类号:
R563.9
DOI:
10.3969/j.issn.1672-271X.2018.06.012
文献标志码:
A
摘要:
DNA甲基化是表观遗传学的重要组成部分，与基因表达异常、DNA损伤修复、基因组的不稳定性、遗传性状的改变密切相关。在外界刺激下，细胞的DNA甲基化可发生动态改变，调控基因的表达，参与各种疾病的病理生理过程。慢性阻塞性肺疾病（COPD）是影响人类健康的重要疾病，其发病机制也是研究的热点，近年来有研究发现表观遗传的改变对COPD的疾病进程及急性加重有重要作用，其中以DNA甲基化改变为主。文章通过小气道上皮细胞、肺组织、痰液、外周血几个方面综述DNA甲基化与COPD的关联性，为COPD的发病机制提供更为广阔的视角。
Abstract:
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参考文献/References:

[1]Wacker ME, Kitzing K, Jorres RA, et al. The contribution of symptoms and comorbidities to the economic impact of COPD: an analysis of the German COSYCONET cohort[J]. Int J Chron Obstruct Pulmon Dis,2017, 12: 3437-3448.
[2]王震凯,汪芳裕.DNA甲基化与肿瘤[J].医学研究生学报,2011,24(6):641-645.
[3]Szulwach KE, Jin P. Integrating DNA methylation dynamics into a framework for understanding epigenetic codes[J]. Bioessays,2014, 36(1): 107-117.
[4]Li C, Zhao S, Zhang N, et al. Differences of DNA methylation profiles between monozygotic twins’ blood samples[J]. Mol Biol Rep,2013, 40(9): 5275-5280.
[5]Adcock IM, Caramori G, Barnes PJ. Chronic obstructive pulmonary disease and lung cancer: new molecular insights[J]. Respiration,2011, 81(4): 265-284.
[6]Vucic EA, Chari R, Thu KL,et al. DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways[J]. Am J Respir Cell Mol Biol,2014, 50(5): 912-922.
[7]Potteti HR, Reddy NM, Hei TK,et al. The NRF2 activation and antioxidative response are not impaired overall during hyperoxia-induced lung epithelial cell death[J]. Oxid Med Cell Longev,2013, 2013: 798401.
[8]Krajka-Kuzniak V, Paluszczak J, Baer-Dubowska W. The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment[J]. Pharmacol Rep,2017, 69(3): 393-402.
[9]Chang J, Zhang Y, Li Y, et al. NrF2/ARE and NF-kappaB pathway regulation may be the mechanism for lutein inhibition of human breast cancer cell[J]. Future Oncol,2018,14(8):719-726.
[10]Noel S, Lee SA, Sadasivam M, et al. KEAP1 Editing Using CRISPR/Cas9 for Therapeutic NRF2 Activation in Primary Human T Lymphocytes[J]. J Immunol,2018,200(5):1929-1936.
[11]Ma Y, Zhu M, Miao L, et al. Mercuric Chloride Induced Ovarian Oxidative Stress by Suppressing Nrf2-Keap1 Signal Pathway and its Downstream Genes in Laying Hens[J]. Biol Trace Elem Res,2018. doi: 10.1007/s12011-018-1244-y. [Epub ahead of print].
[12]Kageyama S, Saito T, Obata M,et al. Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant[J]. Mol Cell Biol,2018. pii: MCB.00642-17.
[13]Suzuki T, Yamamoto M. Molecular basis of the Keap1-Nrf2 system[J]. Free Radic Biol Med,2015, 88(Pt B): 93-100.
[14]Menegon S, Columbano A, Giordano S. The Dual Roles of NRF2 in Cancer[J]. Trends Mol Med,2016, 22(7): 578-593.
[15]Omote N, Hashimoto N, Morise M, et al. Impact of mild to moderate COPD on feasibility and prognosis in non-small cell lung cancer patients who received chemotherapy[J]. Int J Chron Obstruct Pulmon Dis,2017, 12: 3541-3547.
[16]Tong YH, Zhang B, Fan Y, et al. Keap1-Nrf2 pathway: A promising target towards lung cancer prevention and therapeutics[J]. Chronic Dis Transl Med,2015, 1(3): 175-186.
[17]Sundar IK, Yin Q, Baier BS, et al. DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD[J]. Clin Epigenetics,2017, 9: 38.
[18]Tang L, Wang H, Ziolo MT. Targeting NOS as a therapeutic approach for heart failure[J]. Pharmacol Ther,2014, 142(3): 306-315.
[19]Pizarro S, Garcia-Lucio J, Peinado VI, et al. Circulating progenitor cells and vascular dysfunction in chronic obstructive pulmonary disease[J]. PLoS One,2014, 9(8): e106163.
[20]Ives SJ, Harris RA, Witman MA,et al. Vascular dysfunction and chronic obstructive pulmonary disease: the role of redox balance[J]. Hypertension,2014, 63(3): 459-467.
[21]Sudo T, Nitta M, Saya H,et al. Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint[J]. Cancer Res,2004, 64(7): 2502-2508.
[22]Wang P, Lindsay J, Owens TW, et al. Phosphorylation of the proapoptotic BH3-only protein bid primes mitochondria for apoptosis during mitotic arrest[J]. Cell Rep,2014, 7(3): 661-671.
[23]Garcia-Perez C, Roy SS, Naghdi S, et al. Bid-induced mitochondrial membrane permeabilization waves propagated by local reactive oxygen species (ROS) signaling[J]. Proc Natl Acad Sci USA,2012, 109(12): 4497-4502.
[24]Kang MJ, Shadel GS. A Mitochondrial Perspective of Chronic Obstructive Pulmonary Disease Pathogenesis[J]. Tuberc Respir Dis (Seoul),2016, 79(4): 207-213.
[25]Park JW, Ryter SW, Choi AM. Functional significance of apoptosis in chronic obstructive pulmonary disease[J]. COPD,2007, 4(4): 347-353.
[26]Yoo S, Takikawa S, Geraghty P, et al. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD[J]. PLoS Genet,2015, 11(1): e1004898.
[27]Rawluszko-Wieczorek AA, Horbacka K, Krokowicz P, et al. Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer[J]. Mol Cancer Res,2014, 12(8): 1112-1127.
[28]Kabei K, Tateishi Y, Nozaki M,et al. Role of hypoxia-inducible factor-1 in the development of renal fibrosis in mouse obstructed kidney: Special references to HIF-1 dependent gene expression of profibrogenic molecules[J]. J Pharmacol Sci,2018, 136(1): 31-38.
[29]Truong TM, Li H, Dhapare S, et al. Sulfated dehydropolymer of caffeic acid: In vitro anti-lung cell death activity and in vivo intervention in emphysema induced by VEGF receptor blockade[J]. Pulm Pharmacol Ther,2017, 45: 181-190.
[30]Voelkel NF, Vandivier RW, Tuder RM. Vascular endothelial growth factor in the lung[J]. Am J Physiol Lung Cell Mol Physiol,2006, 290(2): L209-L221.
[31]Sood A, Petersen H, Blanchette CM, et al. Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers[J]. Am J Respir Crit Care Med,2010, 182(9): 1098-1104.
[32]Meek PM, Sood A, Petersen H, et al. Epigenetic change (GATA-4 gene methylation) is associated with health status in chronic obstructive pulmonary disease[J]. Biol Res Nurs,2015, 17(2): 191-198.
[33]Bruse S, Petersen H, Weissfeld J,et al. Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion[J]. Respir Res,2014, 15: 2.
[34]Vaidyanathan A, Damodar KS. Response to Metabolic activity of neutrophils is elevated in COPD[J]. Lung India,2016, 33(3): 357-358.
[35]Vaidyanathan A, Damodar KS. Increased metabolic activity of neutrophils in patients with chronic obstructivepulmonary disease[J]. Lung India,2015, 32(6): 589-592.
[36]Matsumura R, Hirakawa J, Sato K, et al. Novel Antibodies Reactive with Sialyl Lewis X in Both Humans and Mice Define Its Critical Role in Leukocyte Trafficking and Contact Hypersensitivity Responses[J]. J Biol Chem,2015, 290(24): 15313-15326.
[37]Qiu W, Baccarelli A, Carey VJ, et al. Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function[J]. Am J Respir Crit Care Med,2012, 185(4): 373-381.
[38]Bayarsaihan D. Epigenetic mechanisms in inflammation[J]. J Dent Res,2011, 90(1): 9-17.
[39]Liu F, Killian JK, Yang M,et al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate[J]. Oncogene,2010, 29(25): 3650-3664.
[40］孔令雯，董竞成. 氧化应激致组蛋白修饰在慢性阻塞性肺病发生发展中的作用［J］.医学研究生学报,2014,27(9):968-972.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2018-11-20