|本期目录/Table of Contents|

[1]苏静综述,林江审校.功能性便秘的发病机制及中西医治疗与离子通道关系的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2018,20(06):618-621.[doi:10.3969/j.issn.1672-271X.2018.06.013]
点击复制

功能性便秘的发病机制及中西医治疗与离子通道关系的研究进展()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第20卷
期数:
2018年06期
页码:
618-621
栏目:
综述
出版日期:
2018-11-20

文章信息/Info

Title:
-
作者:
苏静综述; 林江审校
作者单位：200030上海,上海中医药大学附属龙华医院脾胃病科(苏静、林江)
Author(s):
-
关键词:
功能性便秘; 离子通道; 结肠分泌; 结肠运动
Keywords:
-
分类号:
R256.35
DOI:
10.3969/j.issn.1672-271X.2018.06.013
文献标志码:
A
摘要:
功能性便秘（FC）病因尚不十分明确, 治疗困难。近年来各项针对FC的发病机制及中西医药物研究不断被业内学者所报道。文章主要对近年来有关离子通道与FC关系的基础研究、离子通道介导治疗便秘的临床试验、通便中药对离子通道影响的实验研究以及离子通道在FC发病中的作用进行综述。
Abstract:
-

参考文献/References:

[1]罗马Ⅳ:功能性胃肠病[M].4 版.北京:科学出版社,2016:255-262．
[2]杜娟,徐莉.复方嗜酸乳杆菌联合乳果糖治疗婴幼儿便秘的疗效分析[J].东南国防医药,2012,14(6):546-547.
[3]中华医学会消化病学分会胃肠动力学组.中国慢性便秘诊治指南[J].胃肠病学,2013,18(10):605-612.
[4]王佩佩,罗雯,禹铮，等.慢性便秘的研究进展[J].中国全科医学,2017,20(3):370-374.
[5]唐伟峰,唐晓军,杨巍.功能性便秘的中西医研究进展[J].世界中西医结合杂志,2015,10(6):880-884.
[6]叶必星,李苗苗,李学良，等.慢性便秘的非药物治疗[J]. 中华消化杂志,2012,32(5):294-297.
[7]廖奕,刘诗.慢性功能性便秘病理生理机制研究[J].临床消化病杂志,2013,25(4):225-229.
[8]胡维琨,张虹.角膜氯离子通道的研究进展[J].医学研究生学报,2006,19(5):465-468.
[9]Mercer AJ,Rabl K,Riccardi GE,et al.Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse[J].Neurophysiol,2011,105(1):321-335.
[10]Jentsch TJ.Discovery of CLC transport proteins:cloning,structure,function and pathophysiology[J].J Physiol,2015,593(18):4091-4109.
[11]Brennan SC,Wilkinson WJ,Tseng HE,et al.The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR[J].Sci Rep,2016,25(6):21975.
[12]Cant N,Pollock N,Ford RC.CFTR structure and cystic fibrosis[J].Int J Biochem Cell Biol,2014,52(7):15-25.
[13]Ikpa PT,Bijvelds MJC,De Jonge HR.Cystic fibrosis:Toward personalized therapies[J].Int J Biochem Cell Biol,2014,52(7):192-200.
[14]Kokke FT,van der Doef HP,Beck FJ,et al.Constipation in pediatric cystic fibrosis patients:An underestimated medical condition[J].J Cyst Fibros,2010,9(1):59-63．
[15]Verkman AS,Calietla LJV.Chloride channels as drug targets[J]. Nat Rev Drug Discov,2009,8(2):153-169.
[16]Cil O, Phuan PW, Lee J, et al.CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation[J].Cell Mol Gastroenterol Hepatol,2016,2(3):317-327.
[17]JY J.Role of lubiprostone on gastrointestinal motility[J].J Neurogastroenterol Motil,2013,19(3):277-278．
[18]Johanson JF,Morton D,Geenen J,et al.Multicenter,4-week,double-blind,randomized,placebo controlled trial of lubiprostone,a locally-acting type-2 chloride channel activator,in patients with chronic constipation[J]. Am J Gastroenterol, 2008,103(1):170-177.
[19]Fukudo S,Hongo M,Kaneko H,et al.Lubiprostone increases spontaneous bowel movement frequency and quality of life in patients with chronic idiopathic constipation[J].Clin Gastroenterol Hepatol,2015,13(2):294-301.
[20]Mareya SM,Lichtlen P,Woldegeorgis F,et al.Su2041 lubiprostone improves complete spontaneous bowel movement frequency in chronic non-cancer pain patients with opioid-induced constipation[J].Gastroenterology,2013,144(5):S539-540.
[21]Busby RW,Ortiz S.Clarification of Linaclotide Pharmacology Presented in a Recent Clinical Study of Plecanatide[J].Dig Dis Sci,2014,59(5):1066-1067.
[22]Lembo AJ,Kurtz CB,Macdougall JE,et al.Efficacy of linaclotide for patients with chronic constipation[J].Gastroenterology,2010, 138(3):886-995.
[23]Takayama I,Horiguchi K,Daigo Y,etal.The interstitial cells of Cajal and a gastroenteric pacemaker system[J].Arch Histol Cytol,2002,65(1):1-26.
[24]许海尘,林琳,张红杰,等.慢传输型便秘模型的建立及其机制探讨[J].医学研究生学报,2004,17(6):502-504.
[25]孟萍,尹建康,高晓静,等.白术对慢传输型便秘大鼠结肠组织Cajal间质细胞的影响[J].中医研究,2012,25(9):58-60.
[26]齐清会,刘健,刘勇.Cajal间质细胞与胃肠运动[C].第八届全国中西医结合普通外科临床与基础学术会议暨全国中西医结合外科危重病学习班论文汇编，2003，5:50-54.
[27]Gonzalez-Martinez MA,Ortiz-Olvera NX,Mendez-Navarro J.Novel pharmacological therapies for management of chronic constipation[J].J Clin Gastroenterol,2014,48(1):21-28.
[28]Emmanuel A,Cools M,Vandeplassche L,et al.Prucalopride improves bowel function and colonic transit time in patients with chronic constipation:an integrated analysis[J].Am J Gastroenterol,2014,109(6):887-894.
[29]Anderson UA,Carson C,McCloskey KD.KCNQ currents and their contribution to resting membrane potential and the excitability of interstitial cells of cajal from the guinea pig bladder[J].J Urol,2009,182(1):330-336.
[30]Gade AR,Kang M,Akbarali HI.Hydrogen sulfide as anallosteric modulator of ATP-sensitive potassium channels incolonic inflammation[J].Mol Pharmacol,2013,83(1):294-306.
[31]Seip G,Schultheiss G,Kocks SL,et al.Interaction between store-op-eratednon selective cation channels and the Na+-Ca2+ exchanger during secretion in the rat colon[J].Exp Physiol,2001,86(4):461-468.
[32]张虹,罗和生,谭韡.马来酸曲美布汀对结肠平滑肌细胞钙激活钾通道的影响[J].胃肠病学和肝病学杂志,2011,20(10):920-923.
[33]项贤者,余洪亮,潘秀雅.马来酸曲美布汀治疗结肠慢传输型便秘的临床观察[J].海峡药学,2009,21(9):97-99.
[34]邢益门.马来酸曲美布汀治疗便秘型肠易激综合征73例效果观察[J].中国药业,2014,23(19):100-102.
[35]卢春敬,黄伟锋,欧阳守.大黄素对豚鼠结肠收缩性的影响及其机制的研究[J].海峡药学,2011,23(5):38-41.
[36]林森,侯曙光,金伶伶,等.荷叶碱对野生型和突变型囊性纤维化跨膜电导调节因子氯离子通道的激活作用[J].中国临床药理学与治疗学,2008,13(2):138-143.
[37]林森,侯曙光,金伶伶,等.木犀草素促进囊性纤维化跨膜电导调节因子氯离子通道开放[J].中国临床药理学与治疗学,2008,13(2):249-253.
[38]杨孜欢,潘奥,陈思亮,等.麻仁软胶囊在诱导大鼠结肠上皮细胞阴离子分泌中的作用[J].中药药理与临床,2008,24(4):1-5.
[39]董艳,何春梅,陆金根.益气开秘方调控肠道 Cajal细胞 NO-cGMP-PKG 通路的实验研究[J].上海中医药大学学报,2013,27(3):82-86.

相似文献/References:

[1]杜 娟,徐 莉.复方嗜酸乳杆菌联合乳果糖治疗婴幼儿便秘的疗效分析[J].医学研究与战创伤救治(原医学研究生学报),2012,14(06):546.
[2]袁方正,涂晓文,乔怀宇,等.长QT综合征 15例临床分析[J].医学研究与战创伤救治(原医学研究生学报),2016,18(05):537.[doi:10.3969/j.issn.1672-271X.2016.05.026]
[3]杜娟,徐莉,牟娅妮,等.乳双歧杆菌Bb12辅助治疗儿童功能性便秘疗效分析[J].医学研究与战创伤救治(原医学研究生学报),2021,23(6):610.[doi:10.3969/j.issn.1672-271X.2021.06.011]
　DU Juan,XU Li,MOU Ya-ni,et al.Effects of Bifidobacterium lactis Bb12 in the adjuvant treatment of functional constipation in children[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(06):610.[doi:10.3969/j.issn.1672-271X.2021.06.011]

备注/Memo

备注/Memo:
-
更新日期/Last Update: 2018-11-20