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[1]宁丽萍,王占科,王勋松,等.糖尿病足患者金黄色葡萄球菌感染率和耐药性分析[J].医学研究与战创伤救治(原医学研究生学报),2019,21(01):65-68.[doi:10.3969/j.issn.1672-271X.2019.01.015]
　NING Li-ping,WANG Zhan-ke,WANG Xun-song,et al.Study of infection rate and drug resistance analysis of staphylococcus aureus in patients of diabetic foot[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2019,21(01):65-68.[doi:10.3969/j.issn.1672-271X.2019.01.015]
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糖尿病足患者金黄色葡萄球菌感染率和耐药性分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第21卷
期数:
2019年01期
页码:
65-68
栏目:
临床研究
出版日期:
2019-01-20

文章信息/Info

Title:
Study of infection rate and drug resistance analysis of staphylococcus aureus in patients of diabetic foot
作者:
宁丽萍; 王占科; 王勋松; 李奇; 王庆莅
作者单位：330002南昌，解放军联勤保障部队第九○八医院检验科（宁丽萍、王占科、王庆莅），内分泌科（李奇）；330029南昌,江西省第二人民医院检验科（王勋松）
Author(s):
NING Li-ping1;  WANG Zhan-ke1; WANG Xun-song2;  LI Qi3;  WANG Qing-li1
（1.Clinical Laboratory, the 908th Hospital of the Joint Logistics Support Force， PLA, Nanchang 330002, Jiangxi, China; 2.Clinical Laboratory, the Second People Hospital of Jiangxi, Nanchang 330029, Jiangxi, China; 3. Department of Endocrinology, the 908th Hospital of the Joint Logistics Support Force， PLA, Nanchang 330002, Jiangxi, China）
关键词:
糖尿病足; 金黄色葡萄球菌; 耐甲氧西林金黄色葡萄球菌; 多重耐药性
Keywords:
diabetic foot;  staphylococcus aureus;  methicillin-resistant staphylococcus aureus;  multi-drug resistance
分类号:
R587.2；R446.5
DOI:
10.3969/j.issn.1672-271X.2019.01.015
文献标志码:
A
摘要:
目的 调查糖尿病足患者金黄色葡萄球菌感染率及其耐药情况，为临床合理使用抗菌药物提供实验依据。方法 回顾性分析2014年4月至2017年4月门诊及住院141例糖尿病足感染患者临床资料，采集患者伤口分泌物标本，采用全自动细菌鉴定分析系统鉴定金黄色葡萄球菌，并采用K-B纸片琼脂扩散法进行药物敏感试验，分析金黄色葡萄球菌检出率及抗菌药物耐药率。结果 141例标本中，检出金黄色葡萄球菌52株（36.9%），其中耐甲氧西林金黄色葡萄球菌（MRSA）30株（57.7%），甲氧西林敏感金黄色葡萄球菌（MSSA）22株（42.3%）；MRSA对阿莫西林/克拉维酸钾、氨苄西林/舒巴坦、头孢曲松等抗生素的耐药率明显高于MSSA菌株，差异有统计学意义（P<0.05）。结论 糖尿病足患者伤口金黄色葡萄球菌感染率高，大部分为MRSA，且为多重耐药菌。
Abstract:
Objective To investigate the infection rate and drug resistance ofstaphylococcus aureus (SAU) in diabetic foot (DF) patients and provide experimental basis for rational use of antibacterial drugs in clinical practice.Methods Secretion samples of DF patients were collected from April 2014 to April 2017. Staphylococcus aureus stains were separated by automatic bacterial identification and analyzed their system. The drug sensitivity tests wer performed by Kirby-Bauer paper agar diffusion method.Results A total of 52 strains of SAU were detected from 141 secretion samples from DF patients, and shown with 36.9% detection rate. Among them, 30 strains were methicillin-resistant staphylococcus aureus (MRSA) (57.7%), and 22 stains were methicillin sensitive staphylococcus aureus （MSSA） (42.3%). MRSA had higher drug resistance rate to levofloxacin, amoxicillin/clavulanate potassium, ampicillin/Sulbactam and ceftriaxone than MSSA（P<0.05）.Conclusion The rate of staphylococcus aureus caused wound infection was high in diabetic food patients, most of the pathogens were MRSA with multi-drug resistance.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2019-01-20