|本期目录/Table of Contents|

[1]杨志坚,方泽鸿综述,王彦峰,等.组蛋白去乙酰化酶1/2在多器官缺血缺氧相关疾病中的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2019,21(01):74-78.[doi:10.3969/j.issn.1672-271X.2019.01.017]
　YANG Zhi-jian,FANG Ze-hong reviewing,WANG Yan-feng,et al.Progress study of HDAC1/2 function in multiorgan under ischemia and anoxia diseases[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2019,21(01):74-78.[doi:10.3969/j.issn.1672-271X.2019.01.017]
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组蛋白去乙酰化酶1/2在多器官缺血缺氧相关疾病中的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第21卷
期数:
2019年01期
页码:
74-78
栏目:
综述
出版日期:
2019-01-20

文章信息/Info

Title:
Progress study of HDAC1/2 function in multiorgan under ischemia and anoxia diseases
作者:
杨志坚; 方泽鸿综述; 王彦峰; 叶启发审校
作者单位：430071武汉,武汉大学中南医院肝胆疾病研究院(杨志坚、方泽鸿、王彦峰、叶启发)
Author(s):
YANG Zhi-jian;  FANG Ze-hong reviewing;  WANG Yan-feng;  YE Qi-fa checking
(Hepatobiliary Disease Institution, Zhongnan Hospital of Wuhan University,Wuhan 430071, Hubei,China)
关键词:
组蛋白去乙酰化酶1/2; 缺血; 缺氧
Keywords:
histone acetyltransferase 1/2; ischemia; anoxia
分类号:
R34
DOI:
10.3969/j.issn.1672-271X.2019.01.017
文献标志码:
A
摘要:
表观遗传学机制如DNA甲基化、泛素化、组蛋白修饰等在多种生物学过程中扮演着重要的角色，其中组蛋白乙酰化在肿瘤细胞转移增殖、炎症的诱导、心脑血管疾病等方面发挥重要作用。组蛋白去乙酰化酶1/2（HDAC1/2）属于I类HDACs,在基因调控中发挥重要的表观遗传学修饰作用，近年来已成为研究癌症、心脑血管等疾病的热点。文章主要就HDAC1/2的蛋白质组学的作用机制及在心、脑、肝肾等组织缺血缺氧疾病中的研究进展进行综述。
Abstract:
Epigenetic mechanisms such as DNA methylation, ubiquitination and histone modification play an important role in a variety of biological processes, among which, histone acetylation plays an important role in tumor cell proliferation and proliferation, inflammation induction, cardiovascular and cerebrovascular diseases.HDAC1/2（histone acetyltransferase 1/2，HDAC1/2）belongs to class I HDACs and plays an important epigenetic modification role in gene regulation. Recently, it has become a hot spot for studying cancer cardiovascular and cerebrovascular diseases. We will summarize the research of HDAC1/2 in heart, brain, liver and kidney related hypoxic-ischemic diseases in this article.

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备注/Memo

备注/Memo:
基金项目：武汉大学中南医院科技创新培育基金（cxpy20160032）
更新日期/Last Update: 2019-01-20