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[1]吴奇,韩东阳,李昕.外周血白细胞DNA相对端粒长度与进展性脑梗死患病风险的关联性[J].医学研究与战创伤救治(原医学研究生学报),2019,21(02):135-140.[doi:10.3969/j.issn.1672-271X.2019.02.005]
　WUQi,HANDong-yang,LIXin.The association between telomere length and stroke in progression risk[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2019,21(02):135-140.[doi:10.3969/j.issn.1672-271X.2019.02.005]
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外周血白细胞DNA相对端粒长度与进展性脑梗死患病风险的关联性()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第21卷
期数:
2019年02期
页码:
135-140
栏目:
临床研究
出版日期:
2019-03-20

文章信息/Info

Title:
The association between telomere length and stroke in progression risk
作者:
吴奇; 韩东阳; 李昕
作者单位：450000郑州，郑州大学第二临床医学院（吴 奇、韩东阳）；450000郑州，郑州大学第二附属医院神经内科（李 昕）
Author(s):
WU　Qi1;  HAN　Dong-yang1;  LI　Xin2
（1.Zhengzhou University Second Clinical Medical College，Zhengzhou 450000,Henan,China； 2.Department of Neurology,Second Affiliated Hospital of Zhengzhou University，Zhengzhou 450000,Henan,China）
关键词:
外周血白细胞; 相对端粒长度; 进展性脑梗死; 患病风险
Keywords:
peripheral blood cells;  relative telomere length;  stroke in progression;  risk factors
分类号:
R741
DOI:
10.3969/j.issn.1672-271X.2019.02.005
文献标志码:
A
摘要:
目的　探讨外周血白细胞DNA相对端粒长度(TSR)与进展性脑梗死（SIP）的相关性。 方法　选择郑州大学第二附属医院2016年1月至2018年1月收治的220例SIP患者为研究对象（SIP组），随机抽取来院体检健康人群220例为对照组。以实时定量PCR（qPCR）技术检测2组外周血白细胞DNA相对端粒长度，以对照组平均相对端粒长度的对数（LnTSR）中位数、三分位数和四分位数为分界值，对端粒长度进行二分组（M1组为较短组，M2组为较长组）、三分组（T1、T2、T3组，其中T1组为最短组，T3组为最长组）和四分组（Q1、Q2、Q3、Q4组，其中Q1组为最短组，Q4组为最长组），采用非条件logistic回归模型分析LnTSR与SIP风险的关联性。 结果　SIP组患者外周血白细胞DNA相对端粒长度（2.83±0.82）较对照组（2.84±0.98）短，但差异无统计学意义(P>0.05)。吸烟、动脉粥样硬化、高血压、冠心病和脑卒中史均是影响SIP发生的危险因素（P<0.05）。Logistic回归分析显示，在四分组时（以Q2组为参照），最短端粒长度的风险比值比(OR)为5.82(95%CI=2.75～14.38,P=0.001)，最长端粒长度的OR为3.53(95%CI=1.71～8.92,P=0.001)，均呈明显U型趋势，其他分组计算各组OR值也都呈U型趋势，即过短或是过长的端粒长度都可能增加SIP的患病风险。 结论　外周血白细胞端粒长度与SIP风险明显相关，端粒长度短或较长者患SIP的风险更高，可能是预测SIP患病风险的新指标。
Abstract:
Objective　To investigate the association of relative telomere length of peripheral blood leukocyte DNA and stroke in progression (SIP).　Methods　A total of 220 SIP patients admitted to the Second Affiliated Hospital of Zhengzhou University from January 2016 to January 2018 were selected as subjects (SIP group), and 220 healthy subjects who were admitted to the hospital were randomly selected as the control group. Real-time quantitative PCR (qPCR) was used to detect the relative telomere length of the peripheral blood leukocytes of the two groups. The median, tertile and quartile of the average relative telomere length (LnTSR) of the control group were used as the cutoff value. The telomere length is divided into two groups (M1 group is shorter group, M2 group is longer group), and three groups (T1, T2, T3, T1 group is the shortest group, T3 group is the longest group) and Four groups (Q1, Q2, Q3, Q4, Q1 group is the shortest group, Q4 group is the longest group), and the unconditional logistic regression model is used to analyze the correlation between LnTSR and SIP risk.　Results　Compared with the control group，the peripheral blood leukocyte DNA of the SIP group was shorter than that of the control group，but the difference was not statistically significant (P>0.05).Smoking，atherosclerosis，hypertension，coronary heart disease and stroke history are all risk factors for SIP.Logistic regression analysis showed that the risk ratio of the shortest telomere length was 5.82(95%CI=2.75-14.38,P=0.001)，and the risk ratio of the longest telomere length was 3.53(95%CI=1.71-8.92,P=0.001)，both showing a u-shaped trend，that is，too short or too long telomere length may increase the risk of SIP.　Conclusion　Telomere length increases the risk of SIP，is a new predictor of risk of SIP.

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备注/Memo

备注/Memo:
基金项目：基金项目:河南省医学科技攻关项目（201402018）
更新日期/Last Update: 2019-03-20