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[1]李婷,唐棠综述,初亚男审校.阿司匹林抵抗与基因多态性的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2019,21(02):171-175.[doi:10.3969/j.issn.1672-271X.2019.02.013]
　LITing,TANGTang reviewing,CHUYa?nan checking.Research progress of aspirin resistance and gene polymorphism[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2019,21(02):171-175.[doi:10.3969/j.issn.1672-271X.2019.02.013]
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阿司匹林抵抗与基因多态性的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第21卷
期数:
2019年02期
页码:
171-175
栏目:
综述
出版日期:
2019-03-20

文章信息/Info

Title:
Research progress of aspirin resistance and gene polymorphism
作者:
李婷; 唐棠综述; 初亚男审校
作者单位：210002 南京，东部战区总医院（原南京军区南京总医院）药理科（李 婷、唐 棠、初亚男）
Author(s):
LI　Ting;  TANG　Tang reviewing;  CHU　Ya?nan checking
（Department of Pharmacology, General Hospital of Eastern Theater Command, PLA, Nanjing 210002, Jiangsu, China）
关键词:
阿司匹林抵抗; 基因多态性; 靶标; 糖蛋白受体; 二磷酸腺苷受体; 基因?基因相互作用
Keywords:
aspirin;  gene polymorphism;  target;  glycoprotein receptor;  adenosine diphosphate receptor;  gene?gene interactions
分类号:
R394
DOI:
10.3969/j.issn.1672-271X.2019.02.013
文献标志码:
A
摘要:
阿司匹林作为抗血小板凝集的一线用药，广泛用于心血管阻塞性疾病的预防及治疗，然而，临床观察显示，并非所有患者均能从治疗中获益，部分患者会出现阿司匹林抵抗现象，遗传变异是其主要原因之一。文章主要从阿司匹林作用靶标基因的多态性、糖蛋白受体基因的多态性、二磷酸腺苷受体基因的多态性以及基因?基因相互作用等方面进行综述。
Abstract:
Aspirin is widely used in the prevention and treatment of cardiovascular obstructive diseases as the first line of antiplatelet drugs. However, clinical observations show that not all patients benefit from treatment, and some patients experience aspirin resistance (AR), genetic variation is one of the most important influence factors. This article reviewed the latest research progresses of aspirin in polymorphisms of target genes, polymorphisms of glycoprotein receptor genes, polymorphisms of adenosine diphosphate receptor genes, and gene?gene interactions.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金（21475151）
更新日期/Last Update: 2019-03-20