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[1]施昀青综述,贾桂祯,王林农审校.后弹力层角膜内皮移植术的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2019,21(02):180-184.[doi:10.3969/j.issn.1672-271X.2019.02.015]
　SHIYun-qing reviewing,JIAGui-zhen,WANG Lin-nong checking.New progress of corneal descemet membrane endothelial keratoplasty[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2019,21(02):180-184.[doi:10.3969/j.issn.1672-271X.2019.02.015]
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后弹力层角膜内皮移植术的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第21卷
期数:
2019年02期
页码:
180-184
栏目:
综述
出版日期:
2019-03-20

文章信息/Info

Title:
New progress of corneal descemet membrane endothelial keratoplasty
作者:
施昀青综述; 贾桂祯; 王林农审校
作者单位：210006 南京，南京医科大学附属南京医院（南京市第一医院）眼科(施昀青、贾桂祯、王林农)
Author(s):
SHI　Yun-qing reviewing;  JIA　Gui-zhen; 　WANG Lin-nong checking
（Department of Ophthalmology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu, China）
关键词:
角膜内皮移植术; 后弹力层内皮移植术; 后弹力层(Descemet膜)
Keywords:
endothelial keratoplasty;  descemet membrane endothelial keratoplasty;  descemet membrane
分类号:
R772.2
DOI:
10.3969/j.issn.1672-271X.2019.02.015
文献标志码:
A
摘要:
随着眼科手术技术的不断发展，角膜内皮移植术取得了很大进展，已经代替穿透性角膜移植术成为了治疗角膜内皮病变的首选术式。后弹力层角膜内皮移植术仅用供体Descemet膜与内皮层替换患者损伤的内皮细胞，保留了患者健康的角膜上皮层、前弹力层和基质层，尽可能维持了眼表的完整性，且植片无缝线，手术损伤小，视力恢复快，是角膜内皮移植手术的发展趋势。文章主要就后弹力层角膜内皮移植术的发展进程、手术方式、并发症等方面进行综述。
Abstract:
With the continuous development of the ophthalmic surgical techniques, great progress has been made in corneal endothelial keratoplasty, which has become the preferred surgical method for treating corneal endothelial lesions instead of penetrating keratoplasty. Among all the advanced technologies, descemet membrane endothelial keratoplasty (DMEK) replaces injured endothelial cells with only healthy donor endothelium and descemet membrane, which retains the patients′ healthy corneal epithelium, Bowman’s membrane and the stroma. So it can maintain the integrity of the ocular surface as far as possible. Also, with the sutureless suture, DMEK provides small surgical injury and rapidly visual recovery, it is the development trend of corneal endothelial keratoplasty. In this paper, we review the development course, operation methods, complications and so on of DMEK.

参考文献/References:

[1] Anshu A, Price MO, Tan DTH, et al. Endothelial keratoplasty: a revolution in evolution[J]. Surv Ophthalmol, 2012, 57(3):236-252.
[2] Gorovoy, Mark S. Descemet-Stripping Automated Endothelial Keratoplasty[J]. Cornea, 2006, 25(8):886-889.
[3] Cheng Y, Pels ER. Femtosecond-laser-assisted Descemet’s stripping endothelial keratoplasty[J]. J Cataract Refract Surg, 2007, 33(1):152-155.
[4] Melles GRJ , Ong TS, Ververs B, et al. Descemet membrane endothelial keratoplasty (DMEK)[J]. Cornea, 2006, 25(8):987-990.
[5] Busin M, Madi S, Santorum P, et al. Ultrathin Descemet’s Stripping Automated Endothelial Keratoplasty with the Microkeratome Double-Pass Technique: Two-Year Outcomes[J]. Ophthalmology, 2013, 120(6):1186-1194.
[6] Trinh L, Saubaméa, B, Auclin F, et al. Femtosecond and excimer laser-assisted endothelial keratoplasty (FELEK): A new technique of endothelial transplantation[J]. J Fr Ophtalmol, 2014, 37(3):211-219.
[7] Melles GR. Posterior lamellar keratoplasty: DLEK to DSEK to DMEK[J]. Cornea, 2006, 25(8):879-881.
[8] Anshu A, Price MO, Price FW. Risk of corneal transplant rejection significantly reduced with Descemet’s membrane endothelial keratoplasty[J]. Ophthalmology, 2012, 119(3):536-540.
[9] 张章, 周如侠, 王林农. 角膜内皮移植术新进展[J]. 医学研究生学报, 2015，28(8):889-892.
[10] Anshu A, Price MO, Price FW. Descemet Membrane Endothelial Keratoplasty and Hybrid Techniques for Managing Failed Penetrating Grafts[J]. Cornea, 2013, 32(1):1-4.
[11] Dapena I, Ham L, Droutsas K, et al. Learning Curve in Descemet’s Membrane Endothelial Keratoplasty[J]. Ophthalmology, 2011, 118(11):2147-2154.
[12] Heinzelmann S, Hüther S, B?hringer D, et al. Influence of Donor Characteristics on Descemet Membrane Endothelial Keratoplasty[J]. Cornea, 2014, 33(6):644-648.
[13] Vianna LMM , Stoeger CG, Galloway JD, et al. Risk Factors for Eye Bank Preparation Failure of Descemet Membrane Endothelial Keratoplasty Tissue[J]. Am J Ophthalmol, 2015, 159(5):829-834.e2.
[14] Price MO, Giebel AW, Fairchild KM, et al. Descemet’s Membrane Endothelial Keratoplasty: Prospective Multicenter Study of Visual and Refractive Outcomes and Endothelial Survival[J]. Ophthalmology, 2009, 116(12):2361-2368.
[15] Tenkman LR, Price FW, Price MO. Descemet Membrane Endothelial Keratoplasty Donor Preparation: Navigating Challenges and Improving Efficiency[J]. Cornea, 2014, 33:319-325.
[16] Dua HS, Faraj LA, Saidpullicino D, et al. Human corneal anatomy redefined: a novel pre-Descemet layer (Dua’s layer) [J]. Ophthalmology, 2013, 120(9):1778-1785.
[17] Parekh M, Ruzza A, Salvalaio G, et al. Descemet Membrane Endothelial Keratoplasty Tissue Preparation from Donor Corneas Using a Standardized Submerged Hydro-separation Method[J]. Am J Ophthalmol, 2014, 158(2):277-285.e1.
[18] Ruzza A, Parekh M, Salvalaio G, et al. Bubble technique for Descemet membrane endothelial keratoplasty tissue preparation in an eye bank: air or liquid? [J] Acta Ophthalmologica, 2015, 93(2): e129-e134.
[19] Gabbay IE, Bahar I, Nahum Y, et al. Comparison of Descemet stripping under continuous air flow, manual air injection and balanced salt solution for DMEK: a pilot study[J]. Graefes Arch Clin Exp Ophthalmol, 2017, 255(8):1605-1611.
[20] Kim EY, Kim SY. Effects of trypan blue on corneal endothelial cell viability;Optimal time of Trypan Blue Dye Application to DMEK donor tissue[J]. Acta Ophthalmologica Scandinavica, 2017, 95: S259.
[21] Majmudar PA, Johnson L. Enhancing DMEK Success by Identifying Optimal Levels of Trypan Blue Dye Application to Donor Corneal Tissue[J]. Cornea, 2017; 36(2): 217-221.
[22] Philipp VM, Julia MW, Friedrich EK, et al. Air versus SF6 in DMEK: a fellow eye comparison of side effects[J]. Invest Ophthalmol Vis Sci, 2017;58(8):5701.
[23] Maier AK, Gundlach E, Schroeter J, et al. Influence of the difficulty of graft unfolding and attachment on the outcome in descemet membrane endothelial keratoplasty[J]. Graefes Arch Clin Exp Ophthalmol, 2015, 253: 895.
[24] Baydoun L, Van DK, Dapena I, et al. Repeat Descemet Membrane Endothelial Keratoplasty after Complicated Primary Descemet Membrane Endothelial Keratoplasty[J]. Ophthalmology, 2015, 122(1):8-16.
[25] 陈丽华, 莫纯坚. 抗VEGF药物治疗糖尿病黄斑水肿的临床应用[J]. 东南国防医药, 2015，17(4):414-417.
[26] Heinzelmann S, Maier P, Bohringer D, et al. Cystoid macular oedema following Descemet membrane endothelial keratoplasty[J]. Br J Ophthalmol, 2015, 99(1):98-102.
[27] Stanzel TP, Ersoy L, Sansanayudh W, et al. Immediate Postoperative Intraocular Pressure Changes After Anterior Chamber Air Fill in Descemet Membrane Endothelial Keratoplasty[J]. Cornea, 2015, 35(1):14.
[28] Ham L, Dapena I, Liarakos VS, et al. Mid-term results of Descemet membrane endothelial keratoplasty (DMEK): 4 to 7 years clinical outcome[J]. Am J Ophthalmol, 2016, 171:113-121.
[29] Feng MT, Price MO, Miller JM, et al. Air reinjection and endothelial cell density in Descemet membrane endothelial keratoplasty: Five-year follow-up[J]. J Cataract Refract Surg, 2014, 40(7):1116-1121.
[30] Monnereau C, Quilendrino R, Dapena I, et al. Multicenter study of descemet membrane endothelial keratoplasty: first case series of 18 surgeons[J]. JAMA Ophthalmo, 2014, 132(10):1192.
[31] 叶婷, 卢玉文, 张利, 等. 飞秒激光辅助的角膜深板层移植术围手术期的护理1例[J]. 东南国防医药, 2012, 14(4):364-365.
[32] Dirisamer M, Ham L, Dapena I, et al. Efficacy of descemet membrane endothelial keratoplasty: Clinical outcome of 200 consecutive cases after a learning curve of 25 cases[J]. Arch Ophthal, 2011, 129(11):1435-1443.
[33] Mccauley MB, Price FW, Price MO. Descemet membrane automated endothelial keratoplasty: Hybrid technique combining DSAEK stability with DMEK visual results[J]. J Cataract Refract Surg, 2009, 35(10):1659-1664.
[34] 陈蔚. 自动板层刀辅助的后弹力层前膜角膜内皮移植术[J]. 中华眼视光学与视觉科学杂志, 2017, 19(5):257-260.
[35] Pilger D, Von SC, Bertelmann E, et al. Femtosecond Laser-Assisted Descemetorhexis[J]. Cornea, 2016, 35(10):1274-1278.
[36] Muraine M, Gueudry J, He Z, et al. Novel Technique for the Preparation of Corneal Grafts for Descemet Membrane Endothelial Keratoplasty[J]. Am J Ophthalmol, 2013, 156(5):851-859.
[37] Brissette A, Conlon R, Teichman JC, et al. Evaluation of a New Technique for Preparation of Endothelial Grafts for Descemet Membrane Endothelial Keratoplasty[J]. Cornea, 2015, 34(5):557-559.
[38] 褚婷, 王林农, 于浩,等. 南京市3所高校学生角膜捐献意识调查[J]. 医学研究生学报, 2013, 26(1):57-62.
[39] Silke O, Lamis B, Jack P, et al. Multicenter Study on Descemet membrane endothelial keratoplasty (DMEK) [J]. Invest Ophthalmol Vis Sci, 2017,58(8):4783.
[40] Phillips PM, Phillips LJ, Muthappan V, et al. Experienced DSAEK Surgeon’s Transition to DMEK: Outcomes Comparing the Last 100 DSAEK Surgeries With the First 100 DMEK Surgeries Exclusively Using Previously Published Techniques[J]. Cornea, 2017, 36(3):275-279.

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备注/Memo

备注/Memo:
基金项目:南京市医学科技发展项目（ZKX14034）
更新日期/Last Update: 2019-03-20